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  1. 12201
    “…Our results unravel a bimodal activity of ICP27 that plays a key role in HSV-1-induced host shutoff and identify CPSF as an important factor that mediates regulation of transcription termination. …”
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    Herpes simplex virus blocks host transcription termination via the bimodal activities of ICP27
  2. 12202
    “…Furthermore, full-length transcripts containing the alternatively spliced exon-1 are expressed in a tissue-specific manner. The splicing factor B52/SRp55 binds within the alternative spliced exon 3a and plays a role in this alternative splicing event.…”
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    Dissecting the splicing mechanism of the Drosophila editing enzyme; dADAR
  3. 12203
    “…Here we report that two mitogen-activated protein kinases played opposing roles in neutrophil trafficking. The extracellular signal-regulated kinase (Erk) potentiated G protein-coupled receptor kinase GRK2 activity and inhibited neutrophil migration, whereas p38 MAPK acted as a non-canonical GRK that phosphorylated the formyl peptide receptor FPR1 and facilitated neutrophil migration by blocking GRK2 function. …”
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    Bidirectional Regulation of Neutrophil Migration by MAP Kinases
  4. 12204
    “…The addition of K(2)CO(3) afforded the hydrotrifluoromethylation product, with DMF acting not only as a solvent, but also as the hydrogen source. …”
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    Product Control in Alkene Trifluoromethylation: Hydrotrifluoromethylation, Vinylic Trifluoromethylation, and Iodotrifluoromethylation using Togni Reagent
  5. 12205
    “…In addition to being an enzyme, TG2 also serves as a G protein for several seven transmembrane receptors and acts as a co-receptor for integrin β1 and β3 integrins distinguishing it from other members of the transglutaminase family. …”
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    Transglutaminase 2 in human diseases
  6. 12206
    “…Remarkably, the obligately intracellular bacterium, Ehrlichia chaffeensis, hijacks host cell processes of the mononuclear phagocyte to evade host defenses through mechanisms executed in part by tandem repeat protein (TRP) effectors secreted by the type 1 secretion system. In the past decade, TRP120 has emerged as a model moonlighting effector, acting as a ligand mimetic, nucleomodulin and ubiquitin ligase. …”
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    Ehrlichia TRP effectors: moonlighting, mimicry and infection
  7. 12207
    “…The results indicate that during the COVID-19 pandemic, the reporting rate of IA in young adults was 28.1%, and fear of missing out and boredom proneness played multiple mediation roles in the relationship between psychological distress and IA. …”
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    Psychological distress and internet addiction following the COVID-19 outbreak: Fear of missing out and boredom proneness as mediators
  8. 12208
    “…We uncover a role for NHL-2 as a co-factor in both positively (CSR-1) and negatively (HRDE-1) acting germline 22G-small RNA pathways and the somatic nuclear RNAi pathway. …”
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    The TRIM-NHL protein NHL-2 is a co-factor in the nuclear and somatic RNAi pathways in C. elegans
  9. 12209
    por Yang, Guanqun, Sun, Zhigang, Zhang, Nan
    Publicado 2020
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    Reshaping the role of m6A modification in cancer transcriptome: a review
  10. 12210
    “…Poly(ADP-ribosyl)-ation is a nonprotein posttranslational modification of proteins and plays an integral part in cell physiology and pathology. …”
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    The Sound of Silence: RNAi in Poly (ADP-Ribose) Research
  11. 12211
    por Shen, Qiuhua, Pierce, Janet D.
    Publicado 2015
    “…Coenzyme Q10 is an important micronutrient acting on the electron transport chain of the mitochondria with two major functions: (1) synthesis of adenosine triphosphate (ATP); and (2) a potent antioxidant. …”
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    Supplementation of Coenzyme Q10 among Patients with Type 2 Diabetes Mellitus
  12. 12212
    por Cura, Vincent, Cavarelli, Jean
    Publicado 2021
    “…These reports highlight the crucial role played by PRMT2 and the need for a better characterization of its activity and cellular functions.…”
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    Structure, Activity and Function of the PRMT2 Protein Arginine Methyltransferase
  13. 12213
    “…Thus, Cx36-mediated junctional communication plays a crucial role in autoregulatory control of OT neuronal activity, likely by acting at the postsynaptic sites. …”
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    Role of Connexin 36 in Autoregulation of Oxytocin Neuronal Activity in Rat Supraoptic Nucleus
  14. 12214
    “…Previous research has shown that the AT-Hook Motif Nuclear Localized (AHL) gene family is highly conserved in land plants, playing crucial roles in plant growth and development. …”
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    Genome-wide identification and expression analysis of the AT-hook Motif Nuclear Localized gene family in soybean
  15. 12215
    “…BACKGROUND: Notch pathway plays a complex role depending on cellular contexts: promotes stem cell maintenance or induces terminal differentiation in potential cancer-initiating cells; acts as an oncogene in lymphocytes and mammary tissue or plays a growth-suppressive role in leukemia, liver, skin, and head and neck cancer. …”
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    Notch pathway activation is essential for maintenance of stem-like cells in early tongue cancer
  16. 12216
    “…The mechanism may be through promoting the activation of the Nrf2 signaling pathway, acting on the expression of antioxidant proteins, such as HO-1 and SOD1, reducing oxidative stress damage, and playing a protective effect on brain tissue.…”
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    Repetitive Transcranial Magnetic Stimulation Improves Neuropathy and Oxidative Stress Levels in Rats with Experimental Cerebral Infarction through the Nrf2 Signaling Pathway
  17. 12217
    por Gu, Lijuan, Yang, Linsheng, Li, Hairong
    Publicado 2023
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    Does social capital aid in leveling the income gradient in child mental health? A structural analysis of the left-behind and not-left-behind Chinese children
  18. 12218
    “…Prolactin is a hormone that plays an important role in the regulation of many physiological processes including lactation, reproduction, fat metabolism, and immune response. …”
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    Inflammation and LPS-Binding Protein Enable the Stimulatory Effect of Endotoxin on Prolactin Secretion in the Ovine Anterior Pituitary: Ex Vivo Study
  19. 12219
    por Martins-Marques, Tania
    Publicado 2021
    “…Connecting various cell populations, the ECM plays important functions not only in maintaining the heart structure, but also acting as a signal transducer for intercellular crosstalk. …”
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    Connecting different heart diseases through intercellular communication
  20. 12220
    “…In conclusion, in this study, we demonstrated that IL-17AF1, IL-17AF2, and IL-17AF3 acted as immune cytokines, exerting an antiviral effect by activating the NF-κB signaling pathway.…”
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    Interleukin-17 suppresses grass carp reovirus infection in Ctenopharyngodon idellus kidney cells by activating NF-κB signaling
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