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12221por Hirasawa, Noriyasu“…To date, many studies using histamine receptor antagonists have shown that histamine acts through four types of receptors: H1, H2, H3, and H4. …”
Publicado 2019
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12222“…While the nucleoplasm-facing side acts as a key player for correct pairing of homolog chromosomes and rapid chromosome movements during meiosis, the cytoplasm-facing side plays a pivotal role for sperm head development and proper acrosome formation during spermiogenesis. …”
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12223por Di Matteo, Anna, Belloni, Elisa, Pradella, Davide, Cappelletto, Ambra, Volf, Nina, Zacchigna, Serena, Ghigna, Claudia“…We consider AS programs acting in a specific and non-redundant manner to influence morphological and functional changes involved in cancer angiogenesis. …”
Publicado 2020
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12224“…These findings collectively suggest that syntabulin acts as a linker molecule that is capable of attaching mitochondrial organelles to the microtubule-based motor kinesin-1, and in turn, contributes to anterograde trafficking of mitochondria to neuronal processes.…”
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12225por Xie, Yunli, Jüschke, Christoph, Esk, Christopher, Hirotsune, Shinji, Knoblich, Juergen A.“…Biochemical and genetic experiments show that PP4c acts by dephosphorylating the microtubule binding protein Ndel1, thereby enabling complex formation with Lis1 to form a functional spindle orientation complex. …”
Publicado 2013
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12226“…In mammals, the light input reaches the master circadian clock in the hypothalamic suprachiasmatic nucleus through glutamatergic afferents from the retina, resulting in phase-shifts of the overt rhythms which depend on the time of the day at which light is applied, leading to changes in the activity of circadian core clock genes (i.e., Per1). This circadian gating of the synchronizing effect of light is dependent on the specific activation of signal transduction pathways involving several kinases acting on protein effectors. …”
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12227por Lintilhac, Philip M.“…The relative simplicity of plant developmental systems, having evolved within the universal constraints imposed by the plant cell wall, may allow us to outline a consistent developmental narrative that is not currently possible in the animal kingdom. In this article, I discuss three aspects of the development of the mature form in plants, approaching them in terms of the role played by the biophysics and mechanics of the cell wall during growth. …”
Publicado 2013
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12228por Rossini, Sofia, Gargaro, Marco, Scalisi, Giulia, Bianconi, Elisa, Ambrosino, Sara, Panfili, Eleonora, Volpi, Claudia, Orabona, Ciriana, Macchiarulo, Antonio, Fallarino, Francesca, Mondanelli, Giada“…Src is a protein tyrosine kinase commonly activated downstream of transmembrane receptors and plays key roles in cell growth, migration, and survival signaling pathways. …”
Publicado 2023
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12229por Liu, Kuijie, Yao, Hongliang, Lei, Sanlin, Xiong, Li, Qi, Haizhi, Qian, Ke, Liu, Jiqiang, Wang, Peng, Zhao, Hua“…Moreover, STAT1 acts as a regulator of CRC growth by targeting miR-124. …”
Publicado 2017
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12230“…Suppression of Usp7 caused similar phenotypes as loss of Ssrp1. Furthermore, Usp7 acted by deubiquitinating H2Bub and thereby repressed the expression of MERVL-fused genes. …”
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12232por Heublein, Manfred, Burguillos, Miguel A., Vögtle, F. Nora, Teixeira, Pedro F., Imhof, Axel, Meisinger, Chris, Ott, Martin“…By binding to both the E1-E2 core and the E3 subunit, Kgd4 acts as a molecular adaptor that is necessary to a form a stable α-KGDH enzyme complex. …”
Publicado 2014
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12233por Zhang, Ziyu, Liu, Faying, Xu, YunYun, Huang, Huang, Zou, Yang, Yang, Bicheng, Luo, Yong, Zhang, Quan, Xiong, Anwen, Wang, Liqun, Huang, Ouping“…While GZFLW (Gui Zhi Fu Ling Wan) has been originally used for treating gynecological diseases, however, the molecular mechanism that GZFLW acts on endometriosis is not clear. To investigate the molecular mechanism that GZFLW plays role on endometriosis, iTRAQ (isobaric tags for relative and absolute quantification) proteomics and human endometrial stromal cells (Y14) obtained from a patient with endometriosis were used in in vitro study. …”
Publicado 2018
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12234por Chen, Quangang, Fang, Liurong, Wang, Dang, Wang, Shaohua, Li, Ping, Li, Mao, Luo, Rui, Chen, Huanchun, Xiao, Shaobo“…Autophagy is an evolutionarily conserved lysosome-dependent degradation pathway that acts in the maintenance of cellular homeostasis and plays important functions in viral replication and pathogenesis. …”
Publicado 2012
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12235“…Yields of guaiacol-type compounds and 2,3-dihydrobenzofuran were promoted in the presence of ZnCl(2). Formic acid played two roles: (1) acid-catalyzed cleavage of linkages; (2) acted as an in situ hydrogen donor for hydrodeoxygenation in the presence of Ru/C. …”
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12236“…Here we found that the E3 ubiquitin ligase VHL was required for Tfh cell development and function upon acute virus infection or antigen immunization. VHL acted through the hypoxia-inducible factor 1α (HIF-1α)−dependent glycolysis pathway to positively regulate early Tfh cell initiation. …”
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12237por Kozielewicz, Paweł, Turku, Ainoleena, Bowin, Carl-Fredrik, Petersen, Julian, Valnohova, Jana, Cañizal, Maria Consuelo Alonso, Ono, Yuki, Inoue, Asuka, Hoffmann, Carsten, Schulte, Gunnar“…WNT-Frizzled (FZD) signaling plays a critical role in embryonic development, stem cell regulation and tissue homeostasis. …”
Publicado 2020
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12238por Jung, Yoonji, Artan, Murat, Kim, Nari, Yeom, Jeonghun, Hwang, Ara B., Jeong, Dae-Eun, Altintas, Özlem, Seo, Keunhee, Seo, Mihwa, Lee, Dongyeop, Hwang, Wooseon, Lee, Yujin, Sohn, Jooyeon, Kim, Eun Ji E., Ju, Sungeun, Han, Seong Kyu, Nam, Hyun-Jun, Adams, Linnea, Ryu, Youngjae, Moon, Dong Jin, Kang, Chanhee, Yoo, Joo-Yeon, Park, Sang Ki, Ha, Chang Man, Hansen, Malene, Kim, Sanguk, Lee, Cheolju, Park, Seung-Yeol, Lee, Seung-Jae V.“…Similarly, we showed that DOP1/PAD-1, which acts with MON-2 to traffic macromolecules between the Golgi and endosome, contributed to the longevity of respiration mutants. …”
Publicado 2021
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12239por Chen, Shuxiao, Han, Chenglin, Bian, Shuai, Chen, Jianfeng, Feng, Xuedong, Li, Gang, Wu, Xuejun“…However, chemerin-9 acts as an analog of chemerin to exert an anti-inflammatory effect by binding to CMKLR1. …”
Publicado 2021
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12240por Zhijun, Zhang, Peiyao, Yu, Bing, Huang, Ruifang, Ma, Vinod, Kunnummal Kurungara, Ramakrishnan, Muthusamy“…BACKGROUND: The DoG (Delay of Germination1) family plays a key regulatory role in seed dormancy and germination. …”
Publicado 2022
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