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  1. 12261
    “…Methods: The angiogenic effect of WA-25 was evaluated using a rat aortic ring assay and transgenic zebrafish models were established using transgenic Tg(fli-1:EGFP)(y1) and Tg(kdrl:mCherry(ci5)-fli1a:negfp(y7)) zebrafish embryos. …”
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    Coral-Derived Compound WA-25 Inhibits Angiogenesis by Attenuating the VEGF/VEGFR2 Signaling Pathway
  2. 12262
    por Serrador, Jorge M., Freeman, Roy
    Publicado 2017
    “…However, it is still unclear if cholinergic activation plays a role in this dilation. To determine if enhancing central cholinergic activity with the centrally acting acetylcholinesterase inhibitor, physostigmine would increase CBF when upright compared to the peripherally acting acetylcholinesterase inhibitor, neostigmine, or saline. …”
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    Enhanced Cholinergic Activity Improves Cerebral Blood Flow during Orthostatic Stress
  3. 12263
    “…We conclude that, under physiologic conditions, neither mTR nor mTERT acts as a transcription factor or plays a role in the DNA damage response.…”
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    Comparing effects of mTR and mTERT deletion on gene expression and DNA damage response: a critical examination of telomere length maintenance-independent roles of telomerase
  4. 12264
    “…The nucleotide sequence around the translational initiation site is an important cis-acting element for post-transcriptional regulation. …”
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    The immediate upstream region of the 5′-UTR from the AUG start codon has a pronounced effect on the translational efficiency in Arabidopsis thaliana
  5. 12265
    “…Here, we show that it acts also as an antioxidant in plant leaves, playing a central photoprotective role. …”
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    Plant tolerance to excess light energy and photooxidative damage relies on plastoquinone biosynthesis
  6. 12266
    “…CAR was found to be involved in endothelial mechanotransduction through the regulation of platelet endothelial cell adhesion molecule 1 (PECAM-1) phosphorylation. Our results demonstrate that endothelial CAR is regulated by FSS and that this regulated CAR acts as an important modulator of endothelial mechanotransduction by FSS.…”
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    Coxsackievirus and adenovirus receptor mediates the responses of endothelial cells to fluid shear stress
  7. 12267
    “…Such an anxiolytic effect may underlie the ability of G-1 to increase spatial memory, by acting on the hippocampus.…”
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    GPR30 activation decreases anxiety in the open field test but not in the elevated plus maze test in female mice
  8. 12268
    “…Amino acid substitution of these specific residues in RHOA to the corresponding residues in RAC1 resulted in RHOA association with IQGAP1. Thus, electrostatics most likely plays a decisive role in these interactions.…”
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    Selectivity Determinants of RHO GTPase Binding to IQGAPs
  9. 12269
    por Qu, Zhi, Ji, Shaoping, Zheng, Shanqing
    Publicado 2020
    “…Our results showed that the mTOR pathway indeed played a role in controlling germ cell proliferation, but it was not involved in the neuronal Q-cell divisions occurring in L1-arrested worms. …”
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    BRAF Controls the Effects of Metformin on Neuroblast Cell Divisions in C. elegans
  10. 12270
    “…ISG15 was upregulated and secreted in cultured human CECs in response to challenge in a type 1 IFN-dependent manner. CONCLUSIONS: Our data, for the first time, demonstrate that ISG15 acts as an immunomodulator in the cornea and plays a critical role in controlling fungal keratitis.…”
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    ISG15 in Host Defense Against Candida albicans Infection in a Mouse Model of Fungal Keratitis
  11. 12271
    “…FINDINGS: Hypoxia-induced oxidized ATM promotes glycolytic activity of CAFs by phosphorylating GLUT1 at S490 and increasing PKM2 expression. Moreover, lactate derived from hypoxic CAFs, acting as a metabolic coupling between CAFs and breast cancer cells, promotes breast cancer cell invasion by activating the TGFβ1/p38 MAPK/MMP2/9 signaling axis and fueling the mitochondrial activity in cancer cells. …”
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    Oxidized ATM-mediated glycolysis enhancement in breast cancer-associated fibroblasts contributes to tumor invasion through lactate as metabolic coupling
  12. 12272
    “…The protective role of IL-24 acted on liver cells were mainly IL-20R1-independent. …”
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    Interleukin-24 protects against liver injury in mouse models
  13. 12273
    “…IMPORTANCE The type VI secretion system (T6SS) plays an important role in bacterial competition by mediating the transport of active metal ions. …”
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    An Important Role of the Type VI Secretion System of Pseudomonas aeruginosa Regulated by Dnr in Response to Anaerobic Environments
  14. 12274
    “…It was possible that MF and FA played their own unique roles and acted in synergy to modulate lipid metabolism during crab ovarian maturation. …”
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    Comparative Metabolomics and Lipidomics of Four Juvenoids Application to Scylla paramamosain Hepatopancreas: Implications of Lipid Metabolism During Ovarian Maturation
  15. 12275
    “…Research in our laboratory suggests that iron also plays a pivotal role in intracellular signaling for NF-kappa B activation in hepatic macrophages (HM). …”
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    Signaling role of iron in NF-kappa B activation in hepatic macrophages
  16. 12276
    por Noudoost, Behrad, Moore, Tirin
    Publicado 2011
    “…Experimental and clinical evidence suggest that prefrontal dopamine plays an important role in cognitive functions(3), acting predominantly through D1 receptors (D1Rs). …”
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    CONTROL OF VISUAL CORTICAL SIGNALS BY PREFRONTAL DOPAMINE
  17. 12277
    por Chen, Yun, Wang, Hong-Yang, Chen, Yi-Fang
    Publicado 2021
    “…Upon exposure to As(V), MYB40 directly repressed the expression of PHT1;1, which encodes a main Pi transporter. The As(V)-resistant phenotypes of MYB40-overexpressing lines were impaired by overexpression of PHT1;1, demonstrating an epistatic genetic relationship between MYB40 and PHT1;1. …”
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    The transcription factor MYB40 is a central regulator in arsenic resistance in Arabidopsis
  18. 12278
    “…Additionally, LA was shown to be the main antibiofilm substance in 1-1-4-3. In summary, this study found that the antibiofilm effect of the L. plantarum CFS against S. mutans was attributable to the comprehensive effect of multiple components, among which LA played a dominant role.…”
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    Exploration of the Main Antibiofilm Substance of Lactobacillus plantarum ATCC 14917 and Its Effect against Streptococcus mutans
  19. 12279
    “…The circadian clock system acts as an endogenous timing reference that coordinates many metabolic and physiological processes in plants. …”
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    Inhibition of RNA degradation integrates the metabolic signals induced by osmotic stress into the Arabidopsis circadian system
  20. 12280
    “…Results indicate that the catalytic interplay between Lewis and Brønsted sites both present at the sanidine surface, in cooperation with the London forces acting between the biomolecules and the inorganic surface, plays a crucial role to: i) favour the condensation of glycine to yield oligopeptides as reaction products; ii) inhibit the hydrolysis of the newly formed oligopeptides. …”
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    Formation versus Hydrolysis of the Peptide Bond from a Quantum-mechanical Viewpoint: The Role of Mineral Surfaces and Implications for the Origin of Life
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