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  1. 12341
    “…Our findings show that silencing CSE gene by siRNA reduces phosphorylation and activation of ERK1/2 in LPS-induced RAW 264.7 cells. These findings suggest that siRNA reduces the inflammatory effects of hydrogen sulfide through the ERK-NF-κB signalling pathway and hydrogen sulfide plays its inflammatory role through ERK-NF-κB pathway in these cells.…”
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    Inhibition of Hydrogen Sulfide Production by Gene Silencing Attenuates Inflammatory Activity by Downregulation of NF-κB and MAP Kinase Activity in LPS-Activated RAW 264.7 Cells
  2. 12342
    “…The role of VP is mediated by the stimulation of the V(1a), V(1b), and V(2) receptors as well as the oxytocinergic and purinergic receptors. …”
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    Examining the Role of Vasopressin in the Modulation of Parental and Sexual Behaviors
  3. 12343
    “…The IL-1 cytokines are a newly expanded family, with each of its 11 members playing an important role in health and disease. …”
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    IL-33 and IL-18 in Inflammatory Bowel Disease Etiology and Microbial Interactions
  4. 12344
    “…Antigravity water transport plays important roles in various applications ranging from agriculture, industry, and environmental engineering. …”
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    Biomimetic Antigravity Water Transport and Remote Harvesting Powered by Sunlight
  5. 12345
    “…Surface lipoproteins (SLPs) are peripherally attached to the outer leaflet of the outer membrane in many Gram-negative bacteria, playing significant roles in nutrient acquisition and immune evasion in the host. …”
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    Reconstitution of surface lipoprotein translocation through the Slam translocon
  6. 12346
    “…Another recent field of interest concerns polymorphisms of vitamin D receptor (VDR); in this context, preliminary data suggest that VDR polymorphisms more frequently associated with tumorigenesis are Fok1, Bsm1, Taq1, Apa1, EcoRV, Cdx2; although further studies are needed to clarify their role in the cancer. …”
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    Vitamin D and Cancer
  7. 12347
    “…Taken together, these observations suggest that CASC2 acts as a tumor suppressor and potentially as a competing endogenous RNA (ceRNA) for miR-21, plays important role in IDH1 wild type glioma pathogenesis and patients’ outcomes.…”
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    The Role of CASC2 and miR-21 Interplay in Glioma Malignancy and Patient Outcome
  8. 12348
    “…In contrast, neither MK-212 (6-chloro-2-[1-piperazinyl]-pyrazine), a 5HT1A and 5HT2C receptor agonist, nor ipsapirone or buspirone, which acts as an agonist to 5HT1A receptors, have any effect on OC symptom severity. …”
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    Updated overview of the putative role of the serotoninergic system in obsessive-compulsive disorder
  9. 12349
    “…This has generally necessitated a switch to new drugs and the discontinuation of older ones, after which resistance often only declines slowly or even persists indefinitely. …”
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    Host population structure impedes reversion to drug sensitivity after discontinuation of treatment
  10. 12350
    “…These PfPKG targets include proteins involved in cell signalling, proteolysis, gene regulation, protein export and ion and protein transport, indicating that cGMP/PfPKG acts as a signalling hub that plays a central role in a number of core parasite processes. …”
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    Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion
  11. 12351
    “…In a laboratory experiment, participants played 35 rounds of a dyadic give-some dilemma, in which they acted as individuals or group representatives. …”
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    Coping with noise in social dilemmas: Group representatives fare worse than individuals because they lack trust in others’ benign intentions
  12. 12352
    “…YAP (also known as YAP1 or YAP65) is a transcriptional coactivator that interacts with a number of transcription factors including RUNX and TEAD and plays a pivotal role in controlling cell growth. …”
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    Transformation of normal cells by aberrant activation of YAP via cMyc with TEAD
  13. 12353
    “…Notably, auxin concentration and auxin efflux are controlled by the maternal tissues, acting as a key communication from maternal to filial tissue.…”
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    Auxin efflux controls orderly nucellar degeneration and expansion of the female gametophyte in Arabidopsis
  14. 12354
    “…Electrophysiological experiments elucidate that the unique S441 plays pivotal roles in the binding of hEAAT2 with glutamate or WAY-213613, and the I464-L467-V468 cluster acts as a key structural determinant for the selective inhibition of this transporter by WAY-213613.…”
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    Structural basis of ligand binding modes of human EAAT2
  15. 12355
    “…We show that T-tracts are necessary but not always sufficient for termination and that secondary structures of the nascent RNAs are important auxiliary cis-acting elements. Moreover, we show that the helicase Sen1 plays a key role in a fail-safe termination pathway. …”
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    An integrated model for termination of RNA polymerase III transcription
  16. 12356
    “…Wnt16 shRNA reduced mRNA expression of Runx2, collage type I (Col-1) and osteocalcin (OCN) after 7 days of osteogenic induction, as well as alizarin red staining intensity after 21days. …”
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    Wnt16 signaling promotes osteoblast differentiation of periosteal derived cells in vitro and in vivo
  17. 12357
    “…In the Medical Aid beneficiaries, simultaneous diagnosis of the main metabolic components acted as a significant mediator between income levels and stroke incidence, with 26.6% mediated when diagnosed with two or more diseases and 21.1% when diagnosed with all three. …”
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    Effect of income level on stroke incidence and the mediated effect of simultaneous diagnosis of metabolic syndrome diseases; a nationwide cohort study in South Korea
  18. 12358
    “…There has been a renewed interest in investigating the role of stabilizing selection acting on genome-wide traits such as codon usage bias. …”
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    Evidence for Stabilizing Selection on Codon Usage in Chromosomal Rearrangements of Drosophila pseudoobscura
  19. 12359
    “…The MADS-box gene family plays a crucial role in multiple developmental processes of plants, especially in floral organ specification and the regulation of fruit development and ripening. …”
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    Genome-wide identification and expression analysis of the MADS-box gene family during female and male flower development in Juglans mandshurica
  20. 12360
    “…The carbon sequestration capacity of the region exhibited seasonal variability, increasing from October to March (−264 g C m(−2) year(−1), i.e., 48.4%) while weakening from April to September (−150 g C m(−2) year(−1), i.e., 40.4%) on average. …”
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    An Interannual Comparative Study on Ecosystem Carbon Exchange Characteristics in the Dinghushan Biosphere Reserve, a Dominant Subtropical Evergreen Forest Ecosystem
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