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1221
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1222“…Non-coding RNAs, as novel master regulators, especially long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), play important roles in the regulation of tumorigenesis. lncRNA NEAT1 has recently gained much attention, as it is dysregulated in a broad spectrum of cancers, where it acts as either an oncogene or a tumor suppressor gene. …”
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1223por Iizasa, Sayaka, Iizasa, Ei’ichi, Matsuzaki, Sawako, Tanaka, Hiroyuki, Kodama, Yutaka, Watanabe, Keiichi, Nagano, Yukio“…Lipopolysaccharide (LPS) is a major constituent of the outer membrane of Gram-negative bacteria and acts as a pathogen-associated molecular pattern that triggers immune responses in both plants and animals. …”
Publicado 2016
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1224“…Genetic interaction analysis indicates that the AtRING1a/b-regulated KNOX-I pathway acts largely in a complementary manner with the WUS-AG pathway in controlling floral stem cell maintenance and proper carpel development. …”
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1225Musashi1 inhibit the release of Newcastle disease viruses through preventing apoptosis of DF-1 cellspor Yang, Mengqing, Ma, Jiangang, Chu, Zhili, Cao, Xuhong, Lu, Kejia, Shi, Xiaolei, Tong, Lina, Yan, Chuanqi, Liu, Haijin, Wang, Xinglong, Xiao, Sa, Yang, Zengqi“…The efficient proliferation of Newcastle disease virus (NDV) depends on its inhibition of host cell innate immunity. V protein acts as a nonstructural protein which plays a significant role in virus replication, whereas its function remains to be further explored. …”
Publicado 2021
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1226por Zhang, Xiaohui, Li, Fangyuan, Zhou, Yidong, Mao, Feng, Lin, Yan, Shen, Songjie, Li, Yuntao, Zhang, Sheng, Sun, Qiang“…Therefore, AFAP1-AS1 could play a pivotal role in the treatment of TNBC.…”
Publicado 2021
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1227“…The analysis revealed that GABBR1 is regulated by both of the top two microRNAs and acts as a hub by interacting with many schizophrenia-related genes and sharing several types of transcription-binding sites with its interactors. …”
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1228por Frezza, Valentina, Fierro, Claudia, Gatti, Elena, Peschiaroli, Angelo, Lena, Anna Maria, Petruzzelli, Margherita Annicchiarico, Candi, Eleonora, Anemona, Lucia, Mauriello, Alessandro, Pelicci, Pier Giuseppe, Melino, Gerry, Bernassola, Francesca“…Accumulating evidence has proved that deregulation of ΔNp63 expression plays an oncogenic role in head and neck squamous cell carcinomas (HNSCCs). …”
Publicado 2018
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1229por Allahverdi, Amir, Arefian, Ehsan, Soleimani, Masoud, Ai, Jafar, Yousefi-Ahmadipour, Aliakbar, Babaei, Abouzar, Islam, Md Shahidul, Ebrahimi-Barough, Somayeh“…In conclusions, we identified that miR-4731 plays a tumor suppressor role in GBM cell proliferation and migration by targeting EGFR expression, and miR-4731 may act as a novel biomarker for early diagnosis or therapeutic target of GBM.…”
Publicado 2020
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1230por Zhang, Baoyuan, Lyu, Junfang, Yang, Eun Ju, Liu, Yifan, Wu, Changjie, Pardeshi, Lakhansing, Tan, Kaeling, Chen, Qiang, Xu, Xiaoling, Deng, Chu-Xia, Shim, Joong Sup“…BRCA1 plays a key role in the homologous recombination directed DNA repair, allowing its deficiency to act as a therapeutic target of DNA damaging agents. …”
Publicado 2020
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1231“…Gastric cancer (GC) is one of the most commonly diagnosed malignancies in digestive tract and its underlying molecular mechanism is still not clear, so we aimed to reveal the relationship between GC and UDP-GlcNAc pyrophosphorylase-1 like 1 (UAP1L1). …”
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1232por Guazzi, Paolo, Goitre, Luca, Ferro, Elisa, Cutano, Valentina, Martino, Chiara, Trabalzini, Lorenza, Retta, Saverio Francesco“…The KRIT1 protein contains multiple interaction domains and motifs, suggesting that it might act as a scaffold for the assembly of functional protein complexes involved in signaling networks. …”
Publicado 2012
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1233por Cappai, Maria Grazia, Dimauro, Corrado, Arlinghaus, Michael, Sander, Saara J., Pinna, Walter, Kamphues, Josef“…The Peyer's patches (PPs) in the terminal ileum (TI) play a crucial role in targeting antigens and act as a first line of blockage of pathogens in the small intestine. …”
Publicado 2020
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1234por Vicente-Sánchez, Ana, Sánchez-Blázquez, Pilar, Rodríguez-Muñoz, María, Garzón, Javier“…CONCLUSIONS: The HINT1 protein plays an essential role in the GPCR-NMDAR connection. …”
Publicado 2013
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1235“…Further genetic analyses indicated that the Ndc80 hairpin region might act as a platform for the kinetochore recruitment of Mph1, which is one of the most upstream SAC components in the hierarchy. …”
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1236por Lin, Shu-Xian, Zhang, Qi, Zhang, Hua, Yan, Kevin, Ward, Leanne, Lu, Yong-Bo, Feng, Jian-Quan“…These data suggest that the full-length DMP1 plays no apparent role in the nucleus during odontogenesis.…”
Publicado 2014
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1237por Mair, Norbert, Benetti, Camilla, Andratsch, Manfred, Leitner, Michael G., Constantin, Cristina E., Camprubí-Robles, Maria, Quarta, Serena, Biasio, Wolfgang, Kuner, Rohini, Gibbins, Ian L., Kress, Michaela, Haberberger, Rainer V.“…Immune cells, epithelia and blood cells generate high levels of S1P in inflamed tissue. However, it is not known if S1P acts on the endings of nociceptive neurons, thereby contributing to the generation of inflammatory pain. …”
Publicado 2011
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1238“…Tumor suppressor candidate 2 (Tusc2, also known as Fus1) regulates calcium signaling, and Ca(2+)-dependent nuclear factor of activated T-cells (NFAT) and nuclear factor kappa B (NF-κB) pathways, which play roles in osteoclast differentiation. …”
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1239por Woods, Linda M., Hodges, Craig A., Baart, Esther, Baker, Sean M., Liskay, Michael, Hunt, Patricia A.“…Although the chromosomes are thought to play a major role in organizing the meiotic spindle, it remains unclear how a stable bipolar spindle is established. …”
Publicado 1999
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1240por Harcha, Paloma A., López, Ximena, Sáez, Pablo J., Fernández, Paola, Barría, Iván, Martínez, Agustín D., Sáez, Juan C.“…These data strongly suggest that during antigen recognition, Panx1 Chs contribute to the sustained Ca(2+) signal increase via release of ATP that activates P2 receptors, playing a critical role in the sequential events that leads to degranulation response during Type I hypersensitivity reactions.…”
Publicado 2019
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