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12421“…Skin exposure to UV light for 1 h reduced the iAOC by about 17%, and exposure for 2 h decreased the iAOC by about 30%. …”
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12422por Ichimura, Kimitoshi, Shimizu, Takeshi, Matsumoto, Akio, Hirai, Shinichiro, Yokoyama, Eiji, Takeuchi, Hiroki, Yahiro, Kinnosuke, Noda, Masatoshi“…Enterohemorrhagic Escherichia coli (EHEC) produces Shiga toxin 1 (Stx1) and Shiga toxin 2 (Stx2). Nitric oxide (NO), which acts as an antimicrobial defense molecule, was found to enhance the production of Stx1 and Stx2 in EHEC under anaerobic conditions. …”
Publicado 2017
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12423“…Eukaryotic sliding clamp proliferating cell nuclear antigen (PCNA) plays a critical role as a processivity factor for DNA polymerases and as a binding and acting platform for many proteins. …”
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12424Publicado 1996“…TRAP also increased vascular permeability as demonstrated by extravasation of Evans blue and 125I-labeled serum albumin. The release of bioactive amines played an important role in mediating the TRAP- induced edema; the serotonin/histamine antagonist cryproheptadine and the histamine H2 receptor antagonist cimetidine reduced significantly the edema caused by TRAP. …”
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12425“…The nicotinamide adenine dinucleotide phosphate hydrogen oxidase (NADPH oxidase or NOX) plays a critical role in the inflammatory response and fibrosis in several organs such as the lungs, pancreas, kidney, liver, and heart. …”
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12426“…Evidence has been recently provided that gephyrin phosphorylation plays a key role in these processes. Gephyrin post-translational modifications have been shown to influence the structural remodeling of GABAergic synapses and synaptic plasticity by acting on post-synaptic scaffolding properties as well as stability. …”
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12427por Schaefer, Katja, Wagener, Jeanette, Ames, Ryan M., Christou, Stella, MacCallum, Donna M., Bates, Steven, Gow, Neil A. R.“…Analysis of strains with single and multiple mutations suggested the presence of arginase-dependent and arginase-independent routes for polyamine production. CAR1 played a role in hyphal morphogenesis in response to arginine, and the virulence of a triple mutant was reduced in both Galleria mellonella and Mus musculus infection models. …”
Publicado 2020
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12428“…FBXW7 is an F-box protein serving as the substrate recognition component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase. By selectively targeting many oncoproteins for proteasome-mediated degradation, FBXW7 acts as a typical tumor suppressor. …”
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12429“…In addition, the NLRP3 inflammasome acts as a molecular platform, triggering the activation of caspase-1 and the lysis of IL-1β, IL-18 and Gasdermin D (GSDMD) through different molecular mechanisms. …”
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12430por Looker, Oliver, Blanch, Adam J., Liu, Boyin, Nunez-Iglesias, Juan, McMillan, Paul J., Tilley, Leann, Dixon, Matthew W. A.“…This virulence-mediating structure, called the knob, acts as a scaffold for the presentation of the major virulence antigen, P. falciparum Erythrocyte Membrane Protein-1 (PfEMP1). …”
Publicado 2019
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12431por Liu, Xiaoqing, Zhang, Hongmei, Zhang, Wei, Xu, Wenjing, Li, Songsong, Chen, Xin, Chen, HuataoEnlace del recurso
Publicado 2022
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12433“…Zinc finger myeloid, nervy, and deformed epidermal autoregulatory factor 1-type containing 8 (Zinc finger MYND-type containing 8, ZMYND8) is a transcription factor, a histone H3-interacting protein, and a putative chromatin reader/effector that plays an essential role in regulating transcription during normal cellular growth. …”
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12434por Dίaz, Elva“…Although these factors are related based on sequence similarity, the proteins have evolved diverse actions at excitatory synapses that are not limited to the traditional role ascribed to an AMPAR auxiliary factor. SynDIG4/PRRT1 acts as a typical AMPAR auxiliary protein, while PRRT2 functions at presynaptic sites to regulate synaptic vesicle dynamics and is the causative gene for neurological paroxysmal disorders in humans. …”
Publicado 2021
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12436“…We propose that Npr3 acts as a clearance receptor to regulate local concentrations of natriuretic peptides for optimal cGMP production through Npr1 activation, and as a signaling receptor to control cAMP levels through inhibition of adenylyl cyclase. …”
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12437por Goicoechea, Leire, Conde de la Rosa, Laura, Torres, Sandra, García-Ruiz, Carmen, Fernández-Checa, José C.“…Despite the limited availability of cholesterol in the inner mitochondrial membrane (IMM), the metabolism of cholesterol in the IMM plays important physiological roles, acting as the precursor for the synthesis of steroid hormones and neurosteroids in steroidogenic tissues and specific neurons, respectively, or the synthesis of bile acids through an alternative pathway in the liver. …”
Publicado 2023
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12438“…Additionally, MUS81-EME2 acts on 5′-flap structures to cleave off a duplex arm, in reactions that cannot be promoted by MUS81-EME1. …”
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12439“…Lipopolysaccharide (LPS)-induced endothelial dysfunction plays an important role in the pathogenesis of cardiovascular diseases. …”
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12440por Mao, Yingyan, Wen, Shipeng, Chen, Yulong, Zhang, Fazhong, Panine, Pierre, Chan, Tung W., Zhang, Liqun, Liang, Yongri, Liu, Li“…During co-coagulation, VPR not only plays a key role in the prevention of aggregation of GO sheets but also acts as an interface-bridge between GO and SBR. …”
Publicado 2013
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