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12441por Mollo, Ernesto, Fontana, Angelo, Roussis, Vassilios, Polese, Gianluca, Amodeo, Pietro, Ghiselin, Michael T.“…Before becoming airborne on land, small molecules, almost insoluble in water, already played a key role in aquatic communication, but acting in “contact” forms of olfaction that did not require major molecular innovations to become effective at a distance in air. …”
Publicado 2014
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12442“…EspF protein binds to host SNX9 and N-WASP proteins to promote the colonization of pathogenic bacteria in intestinal epithelial cells; combines with cytokeratin 18, actin, 14-3-3ζ, Arp2/3, profilin, and ZO-1 proteins to intervene in the redistribution of intermediate filaments, the rearrangement of actin, and the disruption of tight junctions; acts together with Abcf2 to boost host cell intrinsic apoptosis; and collaborates with Anxa6 protein to inhibit phagocytosis. …”
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12443por Feng, Panjun, Zhang, Xiaohui, Zhang, Shuo, Liu, Dapeng, Gao, Miao, Ma, Fengjie, Yan, Xun-Wang, Xie, Zhi-Yuan“…Herein, by means of the first-principles calculation method and the Monte Carlo method, we demonstrate that strong interlayer ferromagnetic coupling plays an essential role in enhancing its critical temperature, which acts as a magnetic field to stabilize the ferromagnetism in MnSn multilayers. …”
Publicado 2022
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12444por Li, Bo, Yan, Ya-Ping, Liang, Chen, He, Yu-Ying, Wang, Ying, Li, Meng-Yuan, Chen, Si-Ting, Li, Yue, Liu, Ai-Xia, Yan, Gui-Jun, Yang, Zeng-Ming“…Endometrial decidualization plays a pivotal role during early pregnancy. Compromised decidualization has been tightly associated with recurrent implantation failure (RIF). …”
Publicado 2022
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12445por Lai, Jiun-I, Tseng, Yu-Jhen, Chen, Ming-Huang, Huang, Chi-Ying F., Chang, Peter Mu-Hsin“…P-glycoprotein (also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1) plays a crucial role in determining response against medications, including cancer therapeutics. …”
Publicado 2020
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12446Gonadotropin therapy in assisted reproduction: an evolutionary perspective from biologics to biotech“…Gonadotropin therapy plays an integral role in ovarian stimulation for infertility treatments. …”
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12447por Gautier, Violette, Cayrol, Corinne, Farache, Dorian, Roga, Stéphane, Monsarrat, Bernard, Burlet-Schiltz, Odile, Gonzalez de Peredo, Anne, Girard, Jean-Philippe“…IL-33 is a nuclear cytokine from the IL-1 family that plays important roles in health and disease. …”
Publicado 2016
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12448por Ezat, Mohamed M., Rasmussen, Tine L., Hönisch, Bärbel, Groeneveld, Jeroen, deMenocal, Peter“…Our results suggest that the Norwegian Sea probably acted as a CO(2) source towards the end of Heinrich stadials HS1, HS4 and HS11, and may have contributed to the increase in atmospheric pCO(2) at these times.…”
Publicado 2017
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12449por Gottlieb, Aline, Althoff, Kristina, Grunewald, Laura, Thor, Theresa, Odersky, Andrea, Schulte, Marc, Deubzer, Hedwig E., Heukamp, Lukas, Eggert, Angelika, Schramm, Alexander, Schulte, Johannes H., Künkele, Annette“…Secondary chemotherapy resistance contributes to treatment failure, where TP53 pathway dysfunction plays a key role. MDM2 interaction with TP53 leads to its degradation. …”
Publicado 2017
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12450por Wu, Jing, Yang, Yuanyan, Gao, Shenshen, Jiang, Hong, Wang, Xin-Qiong, Xiao, Yuan, Chen, Xue-Hua, Li, Pu, Xu, Chun-Di“…Furthermore, our mechanistic investigations revealed that ERp29 reversed EMT process in gastric carcinoma, and its effect was related to the inactivation of ERK1/2 and AKT phosphorylation. Thus, we conclude that ERp29 acts as a tumor suppressor gene in gastric cancer, and is expected to become a novel target of the treatment of GC.…”
Publicado 2017
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12451por Yu, Tao, Yu, Hai-Ru, Sun, Jia-Yi, Zhao, Zhao, Li, Shuang, Zhang, Xin-Feng, Liao, Zhi-Xuan, Cui, Ming-Ke, Li, Juan, Li, Chan, Zhang, Qiang“…Moreover, DDIT3 deregulation promoted letrozole-resistance by acting as a potent corepressor of ESR1 transcription. …”
Publicado 2017
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12452“…Mechanistically, the beneficial effects of sensory nerves were induced by the neuropeptide calcitonin gene–related peptide (CGRP), which acted on hematopoietic cells. Additionally, oral capsaicin consumption, which can activate somatosensory nerves by binding to TRPV1, dramatically alleviated acute VOE and significantly prevented chronic liver and kidney damage in SCD mice. …”
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12453por Kee, Teresa R., Espinoza Gonzalez, Pamela, Wehinger, Jessica L., Bukhari, Mohammed Zaheen, Ermekbaeva, Aizara, Sista, Apoorva, Kotsiviras, Peter, Liu, Tian, Kang, David E., Woo, Jung-A. A.“…CHCHD2 is a bi-organellar mediator of oxidative phosphorylation, playing crucial roles in regulating electron flow in the mitochondrial electron transport chain and acting as a nuclear transcription factor for a cytochrome c oxidase subunit (COX4I2) and itself in response to hypoxic stress. …”
Publicado 2021
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12454por Fielding, Ceri A., Aicheler, Rebecca, Stanton, Richard J., Wang, Eddie C. Y., Han, Song, Seirafian, Sepehr, Davies, James, McSharry, Brian P., Weekes, Michael P., Antrobus, P. Robin, Prod'homme, Virginie, Blanchet, Fabien P., Sugrue, Daniel, Cuff, Simone, Roberts, Dawn, Davison, Andrew J., Lehner, Paul J., Wilkinson, Gavin W. G., Tomasec, Peter“…This activating receptor recognizes eight distinct ligands (the MHC Class I polypeptide-related sequences (MIC) A andB, and UL16-binding proteins (ULBP)1–6) induced by cellular stress to promote recognition cells perturbed by malignant transformation or microbial infection. …”
Publicado 2014
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12455“…CONCLUSIONS: Zebularine is capable of inhibiting the crucial cellular events in PCO pathogenesis in vitro. Zebularine acts through the inhibition of DNMT1, and it consequently down regulation of the expression of proliferative and survival genes that relate to pathogenesis of PCO. …”
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12456“…X-ray fluorescence (XRF) analysis revealed that metal ions and some inorganics from raw wastewater precipitated in sludge acted as core to enhance granulation. Raw wastewater characteristics had a positive effect on the granule formation, but the SBR mode operating with periodic feast-famine, shorter settling time, and no return sludge pump played a crucial role in aerobic sludge granulation.…”
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12457“…The purpose of this study was to find the impact of EGCG on the histone posttranslational modifications machinery and chromatin remodeling in human endothelial cells of both microvascular (HMEC-1) and vein (HUVECs) origin. We analyzed the methylation and acetylation status of histones (Western blotting), as well as assessed the activity (fluorometric assay kit) and gene expression (qPCR) of the enzymes playing a prominent role in shaping the human epigenome. …”
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12458por Tsakogiannis, Dimitris, Nikolakopoulou, Asimina, Zagouri, Flora, Stratakos, Grigorios, Syrigos, Konstantinos, Zografos, Eleni, Koulouris, Nikolaos, Bletsa, Garyfalia“…On the other hand, Angiopoietin-2 acts as an inhibitor of the Angiopoietin-1/Tie2 signaling pathways, thus facilitating the destabilization of quiescent endothelium in cases of inflammation and cancer. …”
Publicado 2021
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12459por Iorio, V, Festa, M, Rosati, A, Hahne, M, Tiberti, C, Capunzo, M, De Laurenzi, V, Turco, M C“…Moreover, we show that BAG3 binds to SNAP-25 and syntaxin-1, two components of the t-SNARE complex preventing the interaction between SNAP-25 and syntaxin-1. …”
Publicado 2015
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12460por Horiuchi, Hiroshi, Parajuli, Bijay, Komiya, Hiroyasu, Ogawa, Yuki, Jin, Shijie, Takahashi, Keita, Azuma, Yasu-Taka, Tanaka, Fumiaki, Suzumura, Akio, Takeuchi, Hideyuki“…In addition, IL-19-deficient splenic macrophages expressed elevated levels of major histocompatibility complex (MHC) class II, co-stimulatory molecules, and Th17 cell differentiation-associated cytokines such as IL-1β, IL-6, IL-23, TGF-β1, and TNF-α. These observations indicated that IL-19 plays a critical role in suppression of MS pathogenesis by inhibiting macrophage antigen presentation, Th17 cell expansion, and subsequent inflammatory responses. …”
Publicado 2021
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