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  1. 12481
    “…Using siRNA and ChIP assays, we demonstrated that peroxisome-proliferator-activated receptor γ co-activator-1α (PGC-1α) and co-activator-associated arginine methyltransferase 1 (CARM1) were predominantly recruited to the BSEP promoter upon FXR activation by GE. …”
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    Mechanistic insights into geniposide regulation of bile salt export pump (BSEP) expression
  2. 12482
    “…We propose a model in which PML-II contributes to the transcription of multiple genes via the association of its C-terminal domain with relevant transcription complexes, which promotes the stable assembly of these complexes at promoters/enhancers of target genes, and that in this way PML-II plays a significant role in the development of type I IFN responses.…”
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    Promyelocytic Leukemia Protein Isoform II Promotes Transcription Factor Recruitment To Activate Interferon Beta and Interferon-Responsive Gene Expression
  3. 12483
    “…[Image: see text] Nitric oxide (NO) plays a crucial and important role in cellular physiology and also acts as a signaling molecule for cancer in humans. …”
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    Facile Green Approach for Developing Electrochemically Reduced Graphene Oxide-Embedded Platinum Nanoparticles for Ultrasensitive Detection of Nitric Oxide
  4. 12484
    “…Exogenous treatment with GABA acted through the accumulation of abscisic acid (ABA) in the leaves to significantly decrease stomatal conductance and increase the stomatal closure rate, and the levels of expression of ABA-related genes PYL4, ABI1, ABI2, HAB1, ABF3, and OST1 changed in response to drought. …”
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    Activation of the ABA Signal Pathway Mediated by GABA Improves the Drought Resistance of Apple Seedlings
  5. 12485
    “…As a phytochemical, it acts as a dietary supplement that can delay aging and prevent aging-related disease, such as obesity and diabetes. …”
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    Naringin Alleviates Glucose-Induced Aging by Reducing Fat Accumulation and Promoting Autophagy in Caenorhabditis elegans
  6. 12486
    “…After demonstrating the efficacy of the biguanide metformin (a PGC-1α activator) in a cell model of DS, we extended the study to other molecules that regulate the PGC-1α pathway acting on PPAR genes. …”
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    Pioglitazone Improves Mitochondrial Organization and Bioenergetics in Down Syndrome Cells
  7. 12487
    “…The APOBEC family of proteins comprises deaminase enzymes that edit DNA and/or RNA sequences. The APOBEC3 subgroup plays an important role on the innate immune system, acting on host defense against exogenous viruses and endogenous retroelements. …”
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    The Role of Cytidine Deaminases on Innate Immune Responses against Human Viral Infections
  8. 12488
    “…Calcium (Ca) plays an important role in the pathogenesis of insulin resistance syndrome. …”
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    A Calcium-Deficient Diet in Dams during Gestation Increases Insulin Resistance in Male Offspring
  9. 12489
    “…FliJ binds to the center of the FliI(6) ring and acts as the central stalk to activate the export complex. …”
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    Insight Into Distinct Functional Roles of the Flagellar ATPase Complex for Flagellar Assembly in Salmonella
  10. 12490
    “…The β subunit of voltage-gated Ca(2+) (Ca(V)) channels plays an important role in regulating gating of the α1 pore-forming subunit and its regulation by phosphatidylinositol 4,5-bisphosphate (PIP(2)). …”
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    The HOOK region of voltage-gated Ca(2+) channel β subunits senses and transmits PIP(2) signals to the gate
  11. 12491
    “…The precise contribution of HIF-1a in the adaptive response, however, has not been determined. …”
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    HIF- and Non-HIF-Regulated Hypoxic Responses Require the Estrogen-Related Receptor in Drosophila melanogaster
  12. 12492
    “…The epitopes recognized are located in three distinct domains of the protein corresponding to the core, C1 and C2 protein structure. Eleven age- and sex-matched patients with chronic duodenitis acted as controls. …”
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    Mucosal tissue transglutaminase expression in celiac disease
  13. 12493
    por Auboeuf, Didier
    Publicado 2020
    “…In this article, it is argued that based on a bottom-up approach starting from the physicochemical properties of nucleic and amino acid polymers, we should reject the facts that (i) natural selection plays a dominant role in evolution and (ii) the probability of mutations is independent of the generated phenotype. …”
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    Physicochemical Foundations of Life that Direct Evolution: Chance and Natural Selection are not Evolutionary Driving Forces
  14. 12494
    “…In ternary complexes involving an aromatic compound, wherein a triel bond and a chalcogen bond coexist, both the interactions are weakened or strengthened when the central aromatic molecule acts as a double Lewis base or plays a dual role of both a base and an acid. …”
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    Cooperative effects between π-hole triel and π-hole chalcogen bonds
  15. 12495
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    The role of progranulin in diabetes and kidney disease
  16. 12496
    “…D2 dopamine receptor-mediated suppression of synaptic transmission from interneurons plays a key role in neurobiological functions across species, ranging from respiration to memory formation. …”
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    Dopamine-mediated calcium channel regulation in synaptic suppression in L. stagnalis interneurons
  17. 12497
    “…The study highlights intercultural similarities and the positive role played by more symmetrical relationships in the adjustment of emerging adults in both countries.…”
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    Perceived Parenting Styles and Adjustment during Emerging Adulthood: A Cross-National Perspective
  18. 12498
    “…In this context, new classes of drugs acting either on CB1 and/or CB2 receptors or on synthetic and degradation enzymes of endogenous cannabinoids are being studied. …”
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    Obesity as a Condition Determined by Food Addiction: Should Brain Endocannabinoid System Alterations Be the Cause and Its Modulation the Solution?
  19. 12499
    “…In glioblastoma and melanoma cells, DGKα attenuates apoptosis by enhancing the phosphodiesterase (PDE)-4A1–mammalian target of the rapamycin pathway. As PA activates PKCζ, Raf, and PDE, it is likely that PA generated by DGKα plays an important role in the proliferation/antiapoptosis of cancer cells. …”
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    The Roles of Diacylglycerol Kinase α in Cancer Cell Proliferation and Apoptosis
  20. 12500
    “…Parathyroid Hormone (PTH) plays a crucial role in the maintenance of calcium homeostasis directly acting on bone and kidneys and indirectly on the intestine. …”
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    Parathyroid Hormone (PTH)-Related Peptides Family: An Intriguing Role in the Central Nervous System
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