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  1. 12501
    “…ATP, being a well-known universal high-energy compound, plays an important role as a signaling molecule and together with its metabolite adenosine they both attenuate the release of acetylcholine in the neuro-muscular synapse acting through membrane P2 and P1 receptors, respectively. …”
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    Presynaptic Purinergic Modulation of the Rat Neuro-Muscular Transmission
  2. 12502
    “…Gastrin-releasing peptide (GRP) is a pro-angiogenic ligand secreted by tumors and acts directly upon binding to GRP-receptor in endothelial cells. …”
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    AUTOPHAGY MEDIATES PARACRINE REGULATION OF VASCULAR ENDOTHELIAL CELLS
  3. 12503
    “…We show that the C-terminal lobe of TnC (CTnC) does not move during activation, suggesting that CTnC, together with the coiled coil formed by the TnI and TnT chains (IT arm), acts as a scaffold that holds N-terminal lobe of TnC (NTnC) and the actin binding regions of troponin I. …”
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    Regulatory domain of troponin moves dynamically during activation of cardiac muscle
  4. 12504
    “…Factor V (FV) is a pivotal coagulation factor present in plasma and platelets. It plays an essential role in secondary haemostasis acting as a cofactor in the prothrombinase complex, catalysing the conversion of prothrombin to thrombin. …”
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    Hip Replacement Surgery in 14-Year-Old Girl with Factor V Deficiency: Haemostatic Treatment and Thromboprophylaxis
  5. 12505
    “…Decline or overexpression of autophagic essential genes such as ATG7, ATG5 or Beclin 1 plays a key role in the occurrence and development of HCC but the exact mechanisms are still highly controversial. …”
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    The role of autophagy in hepatocellular carcinoma: friend or foe
  6. 12506
    “…Adiponectin is a cytokine produced by adipocytes and acts as a potential cardioprotective agent and plays an important role in myocardial ischemia/reperfusion injury. …”
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    Adiponectin Protects Hypoxia/Reoxygenation-Induced Cardiomyocyte Injury by Suppressing Autophagy
  7. 12507
    “…Furthermore, the early flowering phenotype of 35S:WRKY41 lines was abolished in the soc1 or lfy background. Together, our results suggest that GV plays a function in promoting flowering, which was co-mediated by WRKY41 and WRKY53 acting as new flowering regulators by directly activating the transcription of SOC1 and LFY in Arabidopsis.…”
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    The Transcription Factors WRKY41 and WRKY53 Mediate Early Flowering Induced by the Novel Plant Growth Regulator Guvermectin in Arabidopsis thaliana
  8. 12508
    “…Indeed, BmALP3 (a paralog of BmALP1) oxidizes BmALP1 to form a water-soluble polymer, leading to dissociation of the βγ–CAT complex and loss of biological activity. …”
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    IgG Fc-binding protein positively regulates the assembly of pore-forming protein complex βγ-CAT evolved to drive cell vesicular delivery and transport
  9. 12509
    por Dimke, Henrik
    Publicado 2011
    “…The thiazide-sensitive NaCl cotransporter (NCC) plays key roles in renal electrolyte transport and blood pressure maintenance. …”
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    Exploring the intricate regulatory network controlling the thiazide-sensitive NaCl cotransporter (NCC)
  10. 12510
    “…The intestinal microvasculature (iMV) plays multiple pathogenic roles during chronic inflammatory bowel disease (IBD). …”
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    In Vitro Entero-Capillary Barrier Exhibits Altered Inflammatory and Exosomal Communication Pattern after Exposure to Silica Nanoparticles
  11. 12511
    “…Amino acids are components of proteins that also exist free-form in the body; their functions can be divided into (1) nutritional, (2) sensory, and (3) biological regulatory roles. …”
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    Regulation of Skeletal Muscle Function by Amino Acids
  12. 12512
    por Žerovnik, Eva
    Publicado 2022
    “…On the basis of my research team’s data on the structure, folding, and aggregation of stefin B, we have proposed that it might regulate proteostasis, possessing a chaperone-like function. In this review, I synthesize these observations and derive some conclusions on possible sources of EPM1 pathology. …”
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    Human stefin B: from its structure, folding, and aggregation to its function in health and disease
  13. 12513
    “…It is found that CuI plays two important roles with atomic Cu/I dopants and CuI precipitates. …”
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    Self‐Tuning n‐Type Bi(2)(Te,Se)(3)/SiC Thermoelectric Nanocomposites to Realize High Performances up to 300 °C
  14. 12514
    “…Chemerin, a chemoattractant protein, acts via a G-protein coupled chemokine receptor, i.e. …”
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    Chemerin induces endothelial cell inflammation: activation of nuclear factor-kappa beta and monocyte-endothelial adhesion
  15. 12515
    “…These and other studies have shed light on a novel signalling pathway in which PfPK2 acts as an upstream regulator of important cGMP-calcium signalling, which plays an important role in parasite invasion.…”
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    Protein kinase PfPK2 mediated signalling is critical for host erythrocyte invasion by malaria parasite
  16. 12516
    “…In lung cancer cells, depletion of eIF4H enhances sensitization to chemotherapy, decreases cell migration and inhibits tumor growth in vivo, in association with reduced translation of mRNA encoding cell-proliferation (c-Myc, cyclin D1) angiogenic (FGF-2) and anti-apoptotic factors (CIAP-1, BCL-xL). …”
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    Key contribution of eIF4H-mediated translational control in tumor promotion
  17. 12517
    “…These findings indicate that water flow plays an important role in the maintenance of specific coral-bacteria associations during times of elevated thermal stress.…”
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    Water flow buffers shifts in bacterial community structure in heat-stressed Acropora muricata
  18. 12518
    “…The melatonin suppression caused by the pinealectomy might contribute to oral cancer development by acting on ERK1/2 and p53 pathways and regulating tumor inflammation.…”
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    Pineal gland protects against chemically induced oral carcinogenesis and inhibits tumor progression in rats
  19. 12519
    “…BACKGROUND: Hepatocyte growth factor (HGF) is a cytokine that has a profound effect on cancer cells by stimulating migration and invasion and acting as an angiogenic factor. In lung cancer, the factor also plays a pivotal role and is linked to a poor outcome in patients. …”
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    YangZheng XiaoJi exerts anti-tumour growth effects by antagonising the effects of HGF and its receptor, cMET, in human lung cancer cells
  20. 12520
    “…BACKGROUND: Family planning plays a key role in improving the health of the mother and the child. …”
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    Factors affecting demand for modern contraceptives among currently married reproductive age women in rural Kebeles of Nunu Kumba district, Oromia, Ethiopia
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