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  1. 12521
    “…They not only promote the proliferation of neurons, but also affect the differentiation direction of neural stem cells by further acting on the Notch signaling pathway. Recently, traditional Chinese medicine (TCM) is a key player in CIRI, through JAK2, STAT3, STAT1 and their phosphorylation. …”
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    The role of JAK/STAT signaling pathway in cerebral ischemia-reperfusion injury and the therapeutic effect of traditional Chinese medicine: A narrative review
  2. 12522
    “…Herein, we report that the experimental drug VMY-1-103 acts through induction of a partial DNA damage-like response as well induction of non-survival autophagy. …”
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    The p53 tumor suppressor protein protects against chemotherapeutic stress and apoptosis in human medulloblastoma cells
  3. 12523
    “…Nevertheless, processing of both ITS1 and ITS2 requires a complete 25S region. The 3΄ ETS plays a minor role in ribosome assembly, but is important for efficient rRNA processing and ribosome maturation. …”
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    Stepwise assembly of the earliest precursors of large ribosomal subunits in yeast
  4. 12524
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    FBP17-mediated finger-like membrane protrusions in cell competition between normal and RasV12-transformed cells
  5. 12525
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    Up-regulated miR-199a-5p in gastric cancer functions as an oncogene and targets klotho
  6. 12526
    “…Previously, we demonstrated that CrkII plays an important role in osteoclast differentiation and function through Rac1 activation both in vitro and in vivo. …”
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    Adaptor protein CrkII negatively regulates osteoblast differentiation and function through JNK phosphorylation
  7. 12527
    “…This brain-specific RAS plays essential roles in brain homeostasis by acting mainly through four angiotensin receptor subtypes; AT(1)R, AT(2)R, MasR, and AT(4)R. …”
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    Brain Renin–Angiotensin System at the Intersect of Physical and Cognitive Frailty
  8. 12528
    “…Angiopoietin-2 (Ang-2) is upregulated under pathological conditions and acts as a context-dependent agonist/antagonist of the Ang-1/Tie2 axis, causing vascular destabilisation and sensitising blood vessels to the effects of vascular endothelial growth factor-A (VEGF-A). …”
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    Angiopoietin/Tie2 signalling and its role in retinal and choroidal vascular diseases: a review of preclinical data
  9. 12529
    “…In fission yeast, the β(1,3)-glucanase Eng2 is a “moonlighting protein” with a dual function, acting as a hydrolase during spore dehiscence, and as component of the endocytic machinery in vegetative cells. …”
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    Eng2, a new player involved in feedback loop regulation of Cdc42 activity in fission yeast
  10. 12530
    por He, Shan, Tao, Ya-Xiong
    Publicado 2014
    “…In addition to the conventional Gs-stimulated cAMP pathway, the MC4R also activates MAPKs, especially ERK1/2. We also showed there is biased signaling in the two signaling pathways, with inverse agonists in the Gs-cAMP pathway acting as agonists for the ERK1/2 pathway. …”
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    Defect in MAPK Signaling As a Cause for Monogenic Obesity Caused By Inactivating Mutations in the Melanocortin-4 Receptor Gene
  11. 12531
    “…OsTDL1a (a TPD1-like gene in rice) encodes a small protein that acts as a cofactor of MSP1 in the same regulatory pathway. …”
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    Dynamic changes of small RNAs in rice spikelet development reveal specialized reproductive phasiRNA pathways
  12. 12532
    “…This chimeric protein acts as an oncogenic factor playing a crucial role in the development of ES. …”
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    Ewing sarcoma from molecular biology to the clinic
  13. 12533
    “…Key players of M-phase entry are the opposing Cdk1 kinase and PP2A-B55δ phosphatase. In Xenopus, the protein Arpp19, phosphorylated at serine 67 by Greatwall, plays an essential role in inhibiting PP2A-B55δ, promoting Cdk1 activation. …”
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    The M-phase regulatory phosphatase PP2A-B55δ opposes protein kinase A on Arpp19 to initiate meiotic division
  14. 12534
    “…LBQ657, the metabolite of sacubitril, could significantly attenuate transforming growth factor-β 1 (TGF-β1) induced cardiac fibrosis by blocking TRPM7 channel, rather than suppressing its protein expression. …”
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    Sacubitril Ameliorates Cardiac Fibrosis Through Inhibiting TRPM7 Channel
  15. 12535
    “…Our previous studies showed that UBTOR/KIAA1024/MINAR1 acts as a negative regulator of mTOR signaling, but whether UBTOR plays a role in neurological diseases remains largely unknown. …”
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    ubtor Mutation Causes Motor Hyperactivity by Activating mTOR Signaling in Zebrafish
  16. 12536
    “…Magnesium (Mg(2+)), the second most abundant cation in cells, plays an essential role in energy production by acting as a cofactor for most enzymes involved in glycolysis and in TCA. …”
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    Phosphatases of regenerating liver are key regulators of metabolism in cancer cells – role of Serine/Glycine metabolism
  17. 12537
    “…Molybdenum (Mo) as essential micronutrient for plants, acts as active component of molybdenum cofactor (Moco). …”
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    Moonlighting Arabidopsis molybdate transporter 2 family and GSH-complex formation facilitate molybdenum homeostasis
  18. 12538
    “…The available data are sufficient to arrive at the conclusion that antidepressant activity of quetiapine is mediated, at least in part, by the active metabolite norquetiapine, which selectively inhibits noradrenaline reuptake, is a partial 5-HT(1A) receptor agonist, and acts as an antagonist at presynaptic α(2), 5-HT(2C), and 5-HT(7) receptors.…”
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    Active Metabolites as Antidepressant Drugs: The Role of Norquetiapine in the Mechanism of Action of Quetiapine in the Treatment of Mood Disorders
  19. 12539
    “…Certain HOXA cluster genes and MEIS1 genes are upregulated in patients and mouse models that express CALM-AF10. …”
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    Nuclear export signal within CALM is necessary for CALM-AF10-induced leukemia
  20. 12540
    “…Histamine causes the rapid formation of focal adherens junctions, disrupting the endothelial barrier by acting on H1R Gα(q)-coupled receptors, which is blunted in endothelial Gα(q/11) KO mice. …”
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    RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock
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