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  1. 12561
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    Exercise improves cognitive dysfunction and neuroinflammation in mice through Histone H3 lactylation in microglia
  2. 12562
    por Riccioni, Graziano
    Publicado 2012
    “…From these observations derives the necessity to find alternative, more selective drugs to reduce HR through inhibition of specific electrical current (I(f)). Ivabradine (IVA) is a novel specific HR-lowering agent that acts in sinus atrial node (SAN) cells by selectively inhibiting the pacemaker I(f) current in a dose-dependent manner by slowing the diastolic depolarization slope of SAN cells, and by reducing HR at rest during exercise in humans. …”
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    Ivabradine: An Intelligent Drug for the Treatment of Ischemic Heart Disease
  3. 12563
    “…CONCLUSIONS: All these data indicate that C3G plays a significant role in different steps of megakaryopoiesis, acting through a mechanism dependent on its GEF activity. …”
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    C3G, through its GEF activity, induces megakaryocytic differentiation and proplatelet formation
  4. 12564
    “…BACKGROUND: The neuroinflammatory response aimed at clearance of herpes simplex virus-1 (HSV-1) plays a key role in the pathogenesis of neuroaxonal damage in herpetic encephalitis. …”
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    Absence of CCR5 increases neutrophil recruitment in severe herpetic encephalitis
  5. 12565
    “…CONCLUSION: Defect in SMN1 gene plays a major role in manifesting of the disease and NAIP (4 and 5) gene acts as a modifying factor in severity of symptoms. …”
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    Genotype-phenotype correlation of survival motor neuron and neuronal apoptosis inhibitory protein genes in spinal muscular atrophy patients from Iran
  6. 12566
    “…Recent studies have demonstrated that NLRP3 inflammasome complex acts as pivotal elements to initiate inflammatory responses and plays an important role in the dysfunction of cardiovascular complications. …”
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    Protection by simvastatin on hyperglycemia-induced endothelial dysfunction through inhibiting NLRP3 inflammasomes
  7. 12567
    “…In conclusion, Hcy may alter the DNA methylation status and DNMT1 acts as the essential enzyme in the methyl transfer process to disturb the status of EC-SOD DNA methylation, leading to decreased expression of EC-SOD and increased oxidative stress and atherosclerosis.…”
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    Extracellular-superoxide dismutase DNA methylation promotes oxidative stress in homocysteine-induced atherosclerosis: EC-SOD DNA methylation regulates atherosclerosis in ApoE (–/–) mice
  8. 12568
    “…CONCLUSION: The coagulation system plays an important role in the development of pleural diseases. …”
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    Does the Evaluation of Coagulation Factors Contribute to Etiological Diagnosis of Pleural Effusions?
  9. 12569
    “…Previous studies have shown that double-stranded RNA–dependent kinase, PKR, plays an important role in the nutrient/pathogen-sensing interface, and acts as a key modulator of chronic metabolic inflammation, insulin sensitivity, and glucose homeostasis in obesity. …”
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    Small-Molecule Inhibitors of PKR Improve Glucose Homeostasis in Obese Diabetic Mice
  10. 12570
    “…A higher concentration, if present during the assembly process of the enzyme, has an inhibitory role on the production of O(2)(•−). Added cholesterol acts on both cytosolic and membrane components, leading to imperfect assembly and decreasing the affinity of cytosolic subunits to the membrane ones. …”
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    Cholesterol: A modulator of the phagocyte NADPH oxidase activity - A cell-free study
  11. 12571
    “…Glucose-6 phosphate is the first intermediate of glucose metabolism and plays a central role in the energy metabolism of the liver. …”
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    Glucose-6 Phosphate, a Central Hub for Liver Carbohydrate Metabolism
  12. 12572
    “…This interaction can be modulated by changing the GAG/contrast agent molar ratio and by acting on the organization of the polymer network. …”
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    Glycosaminoglycans and Contrast Agents: The Role of Hyaluronic Acid as MRI Contrast Enhancer
  13. 12573
    “…The miscibility of the additive and the donor polymer plays a significant role in the enhancement of the device performance, therefore, ternary additives can be designed to better interact with the conjugated polymer. …”
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    Design of ternary additive for organic photovoltaics: a cautionary tale
  14. 12574
    “…Recent studies have shown that MR plays a relevant role in the control of cardiovascular and metabolic function, as well as in adipogenesis. …”
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    Mineralocorticoid Receptor and Aldosterone-Related Biomarkers of End-Organ Damage in Cardiometabolic Disease
  15. 12575
    por Lin, Ling, Luo, Yuanhao, Li, Xin
    Publicado 2018
    “…The molecular weight played as the decisive factor for the adsorption of polyampholyte in the absence of NaCl, while the content of cationic groups acted as the main factor in the presence of NaCl. …”
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    Synthesis of Diblock Polyampholyte PAMPS-b-PMAPTAC and Its Adsorption on Bentonite
  16. 12576
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    Poly(ADP-Ribosyl) Code Functions
  17. 12577
    “…We found that expression of Ag85B was dispensable for the development of iBALT, suggesting that HPIV2 acted as an iBALT-inducing vector. …”
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    Immunological association of inducible bronchus-associated lymphoid tissue organogenesis in Ag85B-rHPIV2 vaccine-induced anti-tuberculosis mucosal immune responses in mice
  18. 12578
    “…Subsequently, our research revealed that rhArg dramatically stimulated autophagic response in NSCLC cells, which was proved by the formation and accumulation of autophagosomes and the conversion of microtubule-associated protein light chain 3 (LC3) from LC3-I to LC3-II. Furthermore, blocking autophagy by chloroquine or LY294002 remarkably enhanced rhArg-induced cytotoxicity and caspase-dependent apoptosis, suggesting that autophagy acted a cytoprotective role in rhArg-treated NSCLC cells. …”
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    A novel and promising therapeutic approach for NSCLC: recombinant human arginase alone or combined with autophagy inhibitor
  19. 12579
    “…Uric acid acts as both an antioxidant and a pre-oxidant that induces oxidative stress; thus, it plays a paradoxical role in inflammation. …”
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    Gout as a risk factor for osteoporosis: A Korean population-based study
  20. 12580
    “…CONCLUSIONS: The present results identify the positive and negative driver somatic mutations acting in MSI-driven tumorigenesis, suggesting that genomic instability in MSI CRC plays a dual role in achieving tumor cell transformation. …”
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    Identification of Positively and Negatively Selected Driver Gene Mutations Associated With Colorectal Cancer With Microsatellite Instability
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