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  1. 1241
    “…Remarkably, one of eight H1 variants, HIS-24, is important for C. elegans development. …”
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    Transcriptional Repression of Hox Genes by C. elegans HP1/HPL and H1/HIS-24
  2. 1242
    “…CONCLUSIONS: This study shows that the phosphorylation state of FLRT1, which is itself FGFR1 dependent, may play a critical role in the potentiation of FGFR1 signalling and may also depend on a SFK-dependent phosphorylation mechanism acting via the FGFR. …”
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    Critical Role of FLRT1 Phosphorylation in the Interdependent Regulation of FLRT1 Function and FGF Receptor Signalling
  3. 1243
    “…Type-I interferons (IFN-I) play an important role in the innate immune response to several retroviruses. …”
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    Effect of Type-I Interferon on Retroviruses
  4. 1244
    “…This effect along with nuclear factor-κB acted to stimulate IL-1β production in activated macrophages. …”
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    FoxO1 Links Insulin Resistance to Proinflammatory Cytokine IL-1β Production in Macrophages
  5. 1245
    “…Emerging studies show that circRNA catenin beta 1 (circCTNNB1) plays a critical role in cancer. …”
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    CircRNA CTNNB1 (circCTNNB1) ameliorates cerebral ischemia/reperfusion injury by sponging miR-96-5p to up-regulate scavenger receptor class B type 1 (SRB1) expression
  6. 1246
    “…CONCLUSIONS: Together, these data indicate that Atf7ip acts in a synergistic fashion with DNA methylation and Xist RNA to maintain the silent state of the Xi in somatic cells, and that Mbd1 and Setdb1, similar to Atf7ip, play a functional role in Xi silencing. …”
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    The Mbd1-Atf7ip-Setdb1 pathway contributes to the maintenance of X chromosome inactivation
  7. 1247
    “…The virus does not rely exclusively on the host cell machinery, but also on viral proteins that act as molecular switches during the viral life cycle which play significant functions in viral pathogenesis, notably by modulating cell signaling. …”
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    Macrophage signaling in HIV-1 infection
  8. 1248
    “…Further in vitro and in vivo experiments indicated that circRPPH1 acted as an oncogene in BC. In addition, circRPPH1 was mainly localized in cytoplasm and played the role of miR-512-5p sponge. …”
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    Circular RNA circRPPH1 promotes breast cancer progression via circRPPH1-miR-512-5p-STAT1 axis
  9. 1249
    “…Since the Rho GTPases play a pivotal role also in several processes in vivo, the potentiality of CNF1 to act as a new pharmacological tool has been explored in experimental animals and in diverse pathological contexts. …”
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    Escherichia coli Cytotoxic Necrotizing Factor 1 (CNF1): Toxin Biology, in Vivo Applications and Therapeutic Potential
  10. 1250
    “…Among the different benzodiazepines, 1,4- and 1,5-benzodiazepines play a far-reaching role in the field of biological activities such as anticonvulsion, anti-anxiety, sedation, and hypnotics. …”
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    Synthetic aspects of 1,4- and 1,5-benzodiazepines using o-phenylenediamine: a study of past quinquennial
  11. 1251
    “…Initially identified as a mammalian apoptosis suppressor, defender against apoptotic death 1 (DAD1) protein has conserved plant orthologs acting as negative regulators of cell death. …”
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    GmDAD1, a Conserved Defender Against Cell Death 1 (DAD1) From Soybean, Positively Regulates Plant Resistance Against Phytophthora Pathogens
  12. 1252
    “…Thus, our results clearly show that HspBP1 acts as an endogenous negative regulator of HIV-1 gene-expression and replication by suppressing NF-κB-mediated activation of viral transcription.…”
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    HSP70 binding protein 1 (HspBP1) suppresses HIV-1 replication by inhibiting NF-κB mediated activation of viral gene expression
  13. 1253
    “…This pathway is likely to play a role in the residual type 1 immunity in IL-12Rβ1 deficiency.…”
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    Residual Type 1 Immunity in Patients Genetically Deficient for Interleukin 12 Receptor β1 (IL-12Rβ1): Evidence for an IL-12Rβ1–Independent Pathway of IL-12 Responsiveness in Human T Cells
  14. 1254
    “…CASTOR1 is shown to be an arginine sensor, which plays an important role in the activation of the mTORC1 pathway. …”
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    Structural insight into the arginine-binding specificity of CASTOR1 in amino acid-dependent mTORC1 signaling
  15. 1255
    “…Namely, the Met residues act as a gate reducing the Cu(I) import rate when two ions simultaneously bind to CTR1. …”
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    The conformational plasticity of the selectivity filter methionines controls the in-cell Cu(I) uptake through the CTR1 transporter
  16. 1256
    “…Cytokines can be proinflammatory or anti-inflammatory. Interleukin (IL)-1β and IL-8 are proinflammatory cytokines that activate additional cytokine cascades and increase seizure susceptibility and organ damage, whereas IL-1 receptor antagonist and IL-10 act as anti-inflammatory cytokines that have protective and anticonvulsant effects. …”
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    The role of cytokines in seizures: interleukin (IL)-1β, IL-1Ra, IL-8, and IL-10
  17. 1257
    “…Mechanistically, MCPIP1 was first demonstrated to act as a splicing factor to regulate AS in TNBC cells. …”
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    MCPIP1-mediated NFIC alternative splicing inhibits proliferation of triple-negative breast cancer via cyclin D1-Rb-E2F1 axis
  18. 1258
    “…We propose that CLASPs can mediate interactions between MT plus ends and the cell cortex and act as local rescue factors, possibly through forming a complex with EB1 at MT tips.…”
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    CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex
  19. 1259
    “…Together, these findings suggest that p53 acts as a molecular switch in monitoring IGF-1-induced proliferation and premature senescence, and suggest a possible molecular connection involving IGF-1-SIRT1-p53 signaling in cellular senescence and aging.…”
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    Insulin-like growth factor-1 regulates the SIRT1-p53 pathway in cellular senescence
  20. 1260
    “…Vascular endothelial zinc finger 1 (VEZF1) plays important roles in endothelial lineage definition and angiogenesis. …”
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    VEZF1–guanine quadruplex DNA interaction regulates alternative polyadenylation and detyrosinase activity of VASH1
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