“…In recent years, significant progress has been made toward understanding the role that the α5 nAChR subunit—and the role of the D398 and N398 variants—plays on nAChR function at the cellular level. These insights stem primarily from a wide range of experimental models, including receptors expressed heterologously in Xenopus oocytes, various cell lines, and neurons derived from human induced pluripotent stem cells (iPSCs), as well as endogenous receptors in genetically engineered mice and—more recently—rats. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Thus, by modulating ROS through the NRF2 pathway, MT3 plays a crucial role in regulating osteoclast differentiation and survival, acting as a metabolic modulator of intracellular zinc ions. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In addition, we find that the non-visual β-arrestin Kurtz (Krz) interacts with Smo and acts in parallel with ubiquitination to downregulate Smo. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…PHF11 interacted with the ssDNA-binding protein RPA and was found in a complex with several nucleases, including the 5′ dsDNA exonuclease EXO1. Biochemical experiments demonstrated that PHF11 stimulates EXO1 by overcoming its inhibition by RPA, suggesting that PHF11 acts (in part) by promoting 5′ end resection at RPA-bound sites of DNA damage. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Fasting also reduced the hypoxia-induced exaggeration of proteostasis defects in animals that express Aβ(1–42) and in animals with a temperature-sensitive mutation in dyn-1, suggesting that this effect was not specific to polyglutamine proteins. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: IL-33 belongs to the IL-1 family, playing a role in several biologic processes as well as in the pathogenesis of different diseases, including skin pathologies. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Here, we show that a host double-stranded DNA (dsDNA), released at the site of cationic liposome injection, plays an essential role for the mucosal adjuvanticity of the cationic liposome. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A 1:1 enzymatic reaction of phenylarsonic acid with the reduced form of FMN (FMNH(2)) and formation of phenylarsonous acid were observed. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Abusive language, repeated acts of violence, and antisocial attitudes have shaped their different personalities and characteristics in accordance with their age. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

Enlace del recurso
Enlace del recurso
Enlace del recurso

Enlace del recurso
Enlace del recurso
Enlace del recurso

“…There is compelling evidence suggesting a pivotal role played by macrophages in orchestrating intestinal wound healing. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Cannabinoid receptor type 1 (CB(1)) blockade with the centrally and peripherally acting rimonabant induces weight loss and improves glucose homeostasis while also causing psychiatric adverse effects. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Finally, we show that under glucose depletion–induced invasion conditions in yeast, more Arf3p is activated to the GTP-bound state, and the activation is independent of Arf3p guanine nucleotide-exchange factor Yel1p. Thus we demonstrate that a novel spatial activation of Arf3p plays a role in regulating Bud2p activation during glucose depletion–induced invasive growth.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The clashing of mitosis and aberrantly expressed meiosis machineries, which may contribute to genomic instability, has been coined cancer “meiomitosis”. LINE-1 retrotransposition, a process active in germ cells, acts outside of the meiotic machinery to create DNA double strand breaks (DNA DSBs) and has played an important role in the evolution of the human genome. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Condensin is also recruited to the RDT1 promoter and is displaced upon HO induction, but does not significantly repress RDT1 transcription. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…SIMPLE SUMMARY: The tumor microenvironment (TME) is a complicated network composed of various cells, signaling molecules, and extra cellular matrix. TME plays a crucial role in triple negative breast cancer (TNBC) immunomodulation and tumor progression, paradoxically, acting as an immunosuppressive as well as immunoreactive factor. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In transcriptome-based public datasets generated from four different tumor types, R-PTP-κ expression was negatively correlated with the expression pattern and prognostic value of two known E2F1 target genes (CCNE1 and CDC25A). Therefore, our results indicate that the R-PTP-κ-E2F axis plays a crucial role in cell growth-inhibitory signaling arising from cell-cell contact conditions.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The indole-3-acetic acid (IAA) auxin is an important endogenous hormone that plays a key role in the regulation of plant growth and development. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso