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  1. 12601
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    Role of PKCtheta in macrophage-mediated immune response to Salmonella typhimurium infection in mice
  2. 12602
    “…Furthermore, DFT results indicated that Thr518 residue oxygen directly attacks the phosphorus, while the His363 residue acts as H-bond acceptor. At the same time, an MD study indicated that Glu234 played an inhibitory role in the α-inhibition helix by regulating the hydrogen bond interaction between Arg374 and the P(γ) of the ATP molecule. …”
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    Investigation of the Detailed AMPylated Reaction Mechanism for the Huntingtin Yeast-Interacting Protein E Enzyme HYPE
  3. 12603
    “…BACKGROUND & AIMS: The complement system plays pivotal roles in innate immunity. Mannose-binding lectin-associated serine protease (MASP)-2 plays essential roles in the activation of the lectin complement pathway. …”
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    Circulating complement factor H levels are associated with disease severity and relapse in autoimmune hepatitis
  4. 12604
    “…Binding of YebC to the promoter region of prtL, oppA (1), and optS, demonstrated by electrophoretic mobility shift assays, showed that YebC acts as a transcriptional repressor of key proteolytic genes.…”
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    YebC, a putative transcriptional factor involved in the regulation of the proteolytic system of Lactobacillus
  5. 12605
    “…Cathepsin-generated elastin peptides increased the calcification of MOVAS-1 cells acting through the ERK1/2 pathway by 34–36%. …”
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    Elastolytic activity of cysteine cathepsins K, S, and V promotes vascular calcification
  6. 12606
    “…Vasa vasorum angiogenesis plays a crucial role in the development of atherosclerosis. …”
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    Vascular endothelial growth factor (VEGF) polymorphism rs3025039 and atherosclerosis among older with hypertension
  7. 12607
    “…Prolactin (PRL) plays an important role in trophoblast growth, placental angiogenesis and immunomodulation within the feto-maternal interface, where different cell types secrete PRL and express its receptor. …”
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    Prolactin decreases LPS-induced inflammatory cytokines by inhibiting TLR-4/NFκB signaling in the human placenta
  8. 12608
    “…Our studies show that fisetin negatively influences MAPK/ERK pathway to impair RNA Pol I activity and rRNA biogenesis. Functionally, we demonstrate that fisetin acts synergistically (CI = 0.4) with RNA Pol I inhibitor, BMH-21 and shows a noteworthy negative impact (60% decrease) on lung colonization of breast cancer cells. …”
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    Novel role of the dietary flavonoid fisetin in suppressing rRNA biogenesis
  9. 12609
    “…Additionally, B. breve UCC2003, acting through Slc2a1 and Fatp1-4 transporters, was shown to restore fetal glycaemia and fetal growth in association with changes in the fetal hepatic transcriptome. …”
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    Maternal gut microbiota Bifidobacterium promotes placental morphogenesis, nutrient transport and fetal growth in mice
  10. 12610
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    ELIXIR-UK role in bioinformatics training at the national level and across ELIXIR
  11. 12611
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    Antiglutamatergic agents for obsessive-compulsive disorder: Where are we now and what are possible future prospects?
  12. 12612
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    Human impact on the recent population history of the elusive European wildcat inferred from whole genome data
  13. 12613
    “…Transcriptional induction of the SAA1 gene is dependent on both C/EBPβ and NF-κB cis-acting elements within the promoter region. …”
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    Serum Amyloid A Protein Concentration in Blood is Influenced by Genetic Differences in the Cheetah (Acinonyx jubatus)
  14. 12614
    “…Its activation can cause the cleavage of inactive pro-caspase-1 into activated caspase-1, that ultimately promotes the transformation of pro-interleukin (IL)-1β and pro-IL-18 into biologically-active IL-1β and IL-18, respectively. …”
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    Involvement of Nucleotide-Binding Oligomerization Domain-Like Receptor Family Pyrin Domain Containing 3 Inflammasome in the Pathogenesis of Liver Diseases
  15. 12615
    “…Cystathionine gamma-lyase (CSE)/hydrogen sulfide (H(2)S) plays a protective role in cardiovascular diseases including hypertension and ischemia/reperfusion (I/R) injury. …”
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    Norswertianolin Promotes Cystathionine γ-Lyase Activity and Attenuates Renal Ischemia/Reperfusion Injury and Hypertension
  16. 12616
    “…HN mediates mitochondrial status and cell survival by acting via an intracellular mechanism, or as a secreted factor via extracellular signals. …”
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    The Molecular Structure and Role of Humanin in Neural and Skeletal Diseases, and in Tissue Regeneration
  17. 12617
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    Differential expression of Oct-4, CD44, and E-cadherin in eutopic and ectopic endometrium in ovarian endometriomas and their correlations with clinicopathological variables
  18. 12618
    “…The intestine is a complex structure that is involved not only in absorption of nutrients, but also acts as a barrier between the individual and the outside world. …”
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    Catheterization of Intestinal Loops in Ruminants
  19. 12619
    por Sheu, Yi-Jun, Stillman, Bruce
    Publicado 2010
    “…At least two cell cycle-regulated protein kinase systems, the S phase-specific cyclin-dependent protein kinases (S-CDKs) and the Dbf4-Cdc7 kinase (DDK, the Dbf4-dependent protein kinase) are essential activators for initiation of DNA replication 1-5. While the essential mechanism of CDK activation of DNA replication in Saccharomyces cerevisiae has been established 6, 7, exactly how DDK acts has been unclear. …”
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    The Dbf4-Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4
  20. 12620
    por Rios, Rosa M.
    Publicado 2014
    “…In this process, AKAP450 plays a central role, acting as a scaffold to recruit other centrosomal proteins important for MT generation. …”
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    The centrosome–Golgi apparatus nexus
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