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  1. 12661
    “…The underlying mechanism acts in cis and involves several chromatin modifiers. …”
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    Antisense transcriptional interference mediates condition-specific gene repression in budding yeast
  2. 12662
    “…We found here that macrophage-derived CXCL9, which acts through CXCR3, is recruited by progressed AP. …”
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    Inhibition of the CXCL9-CXCR3 axis suppresses the progression of experimental apical periodontitis by blocking macrophage migration and activation
  3. 12663
    por Lee Kraus, W, Stokes, MiKayla
    Publicado 2022
    “…Adipogenesis is a complex and tightly regulated process that plays a vital role in multiple aspects of human health. …”
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    OR23-5 Exploring the Role of PARP7 in Adipogenesis
  4. 12664
    “…CONCLUSION: Hsa_circ_0000714 acts as a sponge for miR-370-3p, and regulates RAB17 expression through the CDK6/RB signaling pathway, which plays a role in the malignant progression of the paclitaxel-resistant ovarian cancer cell A2780/PTX.…”
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    Knockdown of Circular RNA Hsa_circ_0000714 Can Regulate RAB17 by Sponging miR-370-3p to Reduce Paclitaxel Resistance of Ovarian Cancer Through CDK6/RB Pathway
  5. 12665
    “…Subgenotype 1a was prevalent in FRI patients in China. B19V showed a high mutation rate, while negative selection acted on the genome.…”
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    The epidemiological and genetic characteristics of human parvovirus B19 in patients with febrile rash illnesses in China
  6. 12666
    “…Macrophages from young mice showed significantly lower TRPM2 expression than those from senescent mice and had significantly lower viability after silica NPs exposure than those from senescent ones. Taken together, these findings demonstrate for the first time that TRPM2 channel acts as an oxidative stress sensor that plays a dual role in silica NPs-induced cytotoxicity by differentially regulating the NADPH oxidase activity and ROS generation.…”
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    A dual role of transient receptor potential melastatin 2 channel in cytotoxicity induced by silica nanoparticles
  7. 12667
    “…This phenotype was characterized by the cellular activation of apoptosis and dedifferentiation, two hallmarks of ADM, whereas at the molecular level, we evidenced a modulation in the expression of transcription factors such as Hnf1β, Sox9, and Hes1. CONCLUSIONS: We demonstrate that TGFβ pathway activation plays a crucial role in pancreatic tumor initiation through its capacity to induce ADM, providing a favorable environment for KRAS(G12D)-dependent carcinogenesis. …”
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    Acinar-to-Ductal Metaplasia Induced by Transforming Growth Factor Beta Facilitates KRAS(G12D)-driven Pancreatic Tumorigenesis
  8. 12668
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    Psychological distress and resilience in patients with advanced cancer during the Covid-19 pandemic: the mediating role of spirituality
  9. 12669
    “…The UDP-glucose ceramide glycosyltransferase (UGCG) enzyme plays a crucial role in the metabolism of sphingolipids through the production of glucosylceramide. …”
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    UGCG modulates heart hypertrophy through B4GalT5-mediated mitochondrial oxidative stress and the ERK signaling pathway
  10. 12670
    “…Recent work has shown that protein complex function can be modulated by RNA molecules providing allosteric regulation or acting as molecular guides or scaffolds. Thus, we hypothesized that RNA plays a role in organizing MAVS signaling platforms. …”
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    CELLULAR RNA INTERACTS WITH MAVS TO PROMOTE ANTIVIRAL SIGNALING
  11. 12671
    “…Through an analysis of phylogenetic relationships, these genes were classified into three distinct clades: class I, class II, and class M. Our investigation included promoter analysis, revealing various cis-acting elements associated with hormones, growth and development, and abiotic stress responses. …”
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    Comparative analysis of KNOX genes and their expression patterns under various treatments in Dendrobium huoshanense
  12. 12672
    “…Mechanistically, we showed that SUN2 exerts its tumor suppressor functions by decreasing the expression of GLUT1 and LDHA to inhibit the Warburg effect. Finally, our results provided evidence that SIRT5 acts, at least partly, as a negative regulator of SUN2.Taken together, our findings indicate that SUN2 is a key component in lung cancer progression by inhibiting the Warburg effect and that the novel SIRT5/SUN2 axis may prove to be useful for the development of new strategies for treating the patients with lung cancer.…”
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    SUN2 exerts tumor suppressor functions by suppressing the Warburg effect in lung cancer
  13. 12673
    “…Here we investigated whether the T. brochymenae response to host walking traces left on leaf surfaces is affected by previous experience in the context of parasitoid foraging behaviour. We found that: 1) an unrewarded experience (successive encounters with host-contaminated areas without successful oviposition) decreased the intensity of the parasitoid response; 2) a rewarded experience (successful oviposition) acted as a reinforcing stimulus; 3) the elapsed time between two consecutive unrewarded events affected the parasitoid response in a host-gender specific manner. …”
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    The response of an egg parasitoid to substrate-borne semiochemicals is affected by previous experience
  14. 12674
    “…B7-H3, a new member of the B7 superfamily, acts as both a T cell costimulator and coinhibitor. …”
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    B7-H3 participates in the development of Asthma by augmentation of the inflammatory response independent of TLR2 pathway
  15. 12675
    “…Primary Sjögren’s syndrome (pSS) is an autoimmune exocrinopathy in which the role that the immune response plays in reducing exocrine gland function, including the glandular microenvironment of cytokines, has not been fully understood. …”
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    Functional effects of proinflammatory factors present in Sjögren’s syndrome salivary microenvironment in an in vitro model of human salivary gland
  16. 12676
    “…Furthermore, the mediation analysis indicated that psychological resilience acted as a full mediator of the association between the fALFF in left OFC and subjective well-being indicators (i.e. life satisfaction and hedonic balance). …”
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    The resilient brain: psychological resilience mediates the effect of amplitude of low-frequency fluctuations in orbitofrontal cortex on subjective well-being in young healthy adults
  17. 12677
    “…We introduce a novel transformation-induced plasticity mechanism, i.e., a martensitic transformation from fcc phase to bcc phase, in medium-entropy alloys (MEAs). …”
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    FCC to BCC transformation-induced plasticity based on thermodynamic phase stability in novel V(10)Cr(10)Fe(45)Co(x)Ni(35−x) medium-entropy alloys
  18. 12678
    “…The adipose-derived circulating hormone leptin plays a pivotal role in the control of energy balance and body weight. …”
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    Developmental Switch of Leptin Action on Network Driven Activity in the Neonatal Rat Hippocampus
  19. 12679
    “…CaMKIIα plays an essential role in decoding Ca(2+) signaling in spines by acting as a leaky Ca(2+) integrator with the time constant of several seconds. …”
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    Mechanisms of Ca(2+)/calmodulin-dependent kinase II activation in single dendritic spines
  20. 12680
    “…In Arabidopsis, MOTHER-OF-FT-AND-TFL1 (MFT) acts as a key negative regulator of germination, modulating GA and ABA responses under shade conditions. …”
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    cis-12-Oxo-phytodienoic acid represses Arabidopsis seed germination in shade conditions
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