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  1. 12721
    “…CONCLUSION: Taken together, these findings indicate that miR-145 acts as a new tumor suppressor by regulating TWIST1 and plays a vital role in the invasive and migration ability of CRC cells.…”
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    MicroRNA-145 Inhibits Cell Migration and Invasion in Colorectal Cancer by Targeting TWIST
  2. 12722
    por Gao, Feng, Li, Ming, Liu, Wenbin, Li, Wei
    Publicado 2020
    “…CONCLUSION: Our data indicate that Tan IIA acts as an EGFR signaling inhibitor, and targeting EGFR-Akt-Mcl1 axis could provide a new option for NSCLC treatment.…”
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    Inhibition of EGFR Signaling and Activation of Mitochondrial Apoptosis Contribute to Tanshinone IIA-Mediated Tumor Suppression in Non-Small Cell Lung Cancer Cells
  3. 12723
    “…The real-time variable-temperature X-ray diffraction measurements with synchrotron radiation at a wide angle have undoubtedly allowed us to observe the presence of the two polymorphs and determine the melting temperature of both crystalline modifications. Furthermore, the CNT plays a nucleating role in the PVDF crystallization, and also acts as reinforcement, increasing the stiffness of the nanocomposites. …”
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    The β Form in PVDF Nanocomposites with Carbon Nanotubes: Structural Features and Properties
  4. 12724
    “…The highest stability of heme was observed under anaerobic reductive conditions (half-life 9.5 days), while the lowest stability was found in the presence of H(2)O(2) (half-life 1 min). We confirmed that the iron cation plays a crucial role in degradation, since protoporphyrin IX, lacking iron, remained significantly more stable. …”
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    Molecular Taphonomy of Heme: Chemical Degradation of Hemin under Presumed Fossilization Conditions
  5. 12725
    por Bilbo, Staci D., Schwarz, Jaclyn M.
    Publicado 2009
    “…Far beyond this limited role however, there is mounting evidence for the vital role the immune system plays within the brain, in both normal, “homeostatic” processes (e.g., sleep, metabolism, memory), as well as in pathology, when the dysregulation of immune molecules may occur. …”
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    Early-Life Programming of Later-Life Brain and Behavior: A Critical Role for the Immune System
  6. 12726
    “…Sonic hedgehog (SHH) plays a central role in patterning numerous embryonic tissues including, classically, the developing limb bud where it controls digit number and identity. …”
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    Direct functional consequences of ZRS enhancer mutation combine with secondary long range SHH signalling effects to cause preaxial polydactyly
  7. 12727
    por Wu, Yuxia, Meng, Kuibin, Liang, Xiaohui
    Publicado 2016
    “…Little is known about the extent to which natural selection in saline environments has acted upon these loci, and what types of nucleotide diversity such selection has given rise to. …”
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    Distinct patterns of natural selection in Na(+)/H(+) antiporter genes in Populus euphratica and Populus pruinosa
  8. 12728
    “…Bacillus thuringiensis is an invertebrate pathogen that produces insecticidal crystal toxins acting on the intestinal barrier. In the Galleria mellonella larvae infection model, toxins from the PlcR virulence regulon contribute to pathogenicity by the oral route. …”
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    Bacillus thuringiensis Spores and Vegetative Bacteria: Infection Capacity and Role of the Virulence Regulon PlcR Following Intrahaemocoel Injection of Galleria mellonella
  9. 12729
    “…The results indicate that the extracts possess a strong and broad spectrum of antioxidant capacity and that their complex composition plays a key role, with various constituents acting complementarily and synergistically.…”
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    Sorbus domestica Leaf Extracts and Their Activity Markers: Antioxidant Potential and Synergy Effects in Scavenging Assays of Multiple Oxidants
  10. 12730
    “…Methods: Tumor-associated macrophages (TAM) is a promising drug target for inhibiting tumor growth, overcoming drug resistance, and anti-metastasis. TAM also plays an essential role in regulating tumor microenvironment. …”
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    BBB-penetrating codelivery liposomes treat brain metastasis of non-small cell lung cancer with EGFR(T790M) mutation
  11. 12731
    “…The blood–brain barrier (BBB) plays an important protective role in the central nervous system and maintains its homeostasis. …”
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    Modulation of Blood–Brain Barrier Permeability by Activating Adenosine A2 Receptors in Oncological Treatment
  12. 12732
    “…It has been shown that ACE2 plays a role in systemic regulation of the cardiovascular and renal systems, lungs and liver by acting on blood pressure, electrolyte balance control mechanisms and inflammation. …”
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    Angiotensin-Converting Enzyme 2 (ACE2) as a Potential Diagnostic and Prognostic Biomarker for Chronic Inflammatory Lung Diseases
  13. 12733
    por Yang, Liu, Wu, Qinyao
    Publicado 2021
    “…Perceived discrimination played a reversed moderated role in the effect of social comparison on psychological integration, i.e., the lower the degree of perceived discrimination, the stronger the positive effect of social comparison on psychological integration, and vice versa. …”
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    Group Differences in the Psychological Integration Path of the Rural-to-Urban Migrants: A Conditional Process Analysis
  14. 12734
    “…Furthermore, trapping and electron spin resonance experiments showed that h(+) and ˙O(2)(−) played a certain role in the degradation process and that ˙OH acted as assistant.…”
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    Construction of a novel two-dimensional AgBiO(3)/BiOBr step-scheme heterojunction for enhanced broad-spectrum photocatalytic performance
  15. 12735
    por Duan, Weiwei, Qin, Tianbao
    Publicado 2022
    “…(1) Background: During the COVID-19 pandemic, the methods used to ensure the quality of public health and life changed. …”
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    The Impact of China’s Legal System on Public Health and Quality of Life during the COVID-19 Pandemic: An Empirical Study
  16. 12736
    por Nakayama, Kei, Hasegawa, Hiroshi
    Publicado 2022
    “…Among various signaling mediators, nitric oxide plays important roles in response to ethanol. Endothelial and inducible nitric oxide synthases (eNOS and iNOS) are upregulated and activated by ethanol and enhance neuroinflammation. …”
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    Blood Vessels as a Key Mediator for Ethanol Toxicity: Implication for Neuronal Damage
  17. 12737
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    Combined pigmentary and structural effects tune wing scale coloration to color vision in the swallowtail butterfly Papilio xuthus
  18. 12738
    “…These findings suggest that photosynthetic electron flow plays a role in controlling the light-dependent expression of flg22-inducible defense genes.…”
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    Light-dependent expression of flg22-induced defense genes in Arabidopsis
  19. 12739
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    The Highwire Ubiquitin Ligase Promotes Axonal Degeneration by Tuning Levels of Nmnat Protein
  20. 12740
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    Mitochondrial membrane lipidome defines yeast longevity
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