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  1. 12741
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    C. elegans flavin-containing monooxygenase-4 is essential for osmoregulation in hypotonic stress
  2. 12742
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    A large-scale analysis of mRNA polyadenylation of human and mouse genes
  3. 12743
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    LncRNA-BC069792 suppresses tumor progression by targeting KCNQ4 in breast cancer
  4. 12744
    “…Subsequent analysis revealed that the epinephrine signaling acts as an important regulator of endometrial receptivity through the PI3K-AKT and FOXO1 signaling pathways. …”
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    Maternal anxiety affects embryo implantation via impairing adrenergic receptor signaling in decidual cells
  5. 12745
    “…Consistently, we find that reductions in FMRP downregulate both the canonical WNT/β-Catenin and the non-canonical WNT-ERK1/2 signalling pathways, reducing the stability of several key transcription factors (i.e. β-Catenin, CREB and ETS1) previously implicated in the modulation of malignant features of glioma cells. …”
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    FMRP modulates the Wnt signalling pathway in glioblastoma
  6. 12746
    por Liu, Kangkang, Wang, Lining, Sun, Erlin
    Publicado 2019
    “…BACKGROUND: MiR-221, acting as onco-miR or oncosuppressor-miR, plays an important role in tumor progression; however, the prognostic value of miR-221 in human carcinomas is controversial and inconclusive. …”
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    Prognostic value of miR-221 in human malignancy: evidence from 3041 subjects
  7. 12747
    “…We investigated the role that the heat shock transcription factor HSF-1 played in determining a stimulatory phenotype of Caenorhabditis elegans in response to physiologically relevant concentrations of ethanol (17 mM; 0.1% v/v). …”
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    Ethanol Stimulates Locomotion via a G(αs)-Signaling Pathway in IL2 Neurons in Caenorhabditis elegans
  8. 12748
    “…In the present study we examined whether TQ alleviates in vivo and in vitro neurodegeneration induced by 1-methyl-4-phenylpyridinium (MPP(+)) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by acting as an activator of the Nrf2/ARE cascade. …”
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    Thymoquinone Prevents Dopaminergic Neurodegeneration by Attenuating Oxidative Stress Via the Nrf2/ARE Pathway
  9. 12749
    “…CONCLUSION: Our findings disprove the -1 triplet hypothesis. The -1 triplet is not required for accommodation of tmRNA into the ribosome, although it plays a minor role in frame selection. …”
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    The role of upstream sequences in selecting the reading frame on tmRNA
  10. 12750
    “…Similar inhibition was observed using inhibitors of IκB-kinase-2 (SC514) and MEK1/2 (U0126), both downstream effectors of PKC. …”
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    Pro-inflammatory mechanisms of muscarinic receptor stimulation in airway smooth muscle
  11. 12751
    “…We show that Ehd4 up-regulates the expression of the “florigen” genes Hd3a and RFT1 through Ehd1, but it acts independently of other known Ehd1 regulators. …”
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    Ehd4 Encodes a Novel and Oryza-Genus-Specific Regulator of Photoperiodic Flowering in Rice
  12. 12752
    “…Ficolin-2 is an activator of the complement system that acts via the lectin pathway. Complement activation plays a substantial role in the renal injury inherent to kidney transplantation. …”
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    Ficolin-2 Gene rs7851696 Polymorphism is Associated with Delayed Graft Function and Acute Rejection in Kidney Allograft Recipients
  13. 12753
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    Transcription factor FfMYB15 regulates the expression of cellulase gene FfCEL6B during mycelial growth of Flammulina filiformis
  14. 12754
    “…Mannosyl (alpha-1,6-)-Glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase (MGAT5) is exclusively expressed in gastric carcinoma, and plays an essential role in cancer progression, but no targeted drug is available so far. …”
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    Hydrogen Sulfide Demonstrates Promising Antitumor Efficacy in Gastric Carcinoma by Targeting MGAT5()()
  15. 12755
    “…Insufficient oxygen availability (hypoxia) plays critical roles in the pathogenesis of both CVDs and cancer diseases, and hypoxia-inducible factor 1 (HIF-1), the main sensor of hypoxia, acts as a central regulator of multiple target genes in the human body. …”
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    The Interplay of Hypoxia Signaling on Mitochondrial Dysfunction and Inflammation in Cardiovascular Diseases and Cancer: From Molecular Mechanisms to Therapeutic Approaches
  16. 12756
    por Hokin, Mabel R., Hokin, Lowell E.
    Publicado 1967
    “…The observations suggest that this phosphatidic acid plays some role in the over-all secretory process.…”
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    The Formation and Continuous Turnover of a Fraction of Phosphatidic Acid on Stimulation of NaCl Secretion by Acetylcholine in the Salt Gland
  17. 12757
    “…The neuropeptide CGRP, acting through the G-protein coupled receptor CALCRL and its coreceptor RAMP1, plays a key role in migraines, which has led to the clinical development of several inhibitory compounds. …”
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    CGRP Signaling via CALCRL Increases Chemotherapy Resistance and Stem Cell Properties in Acute Myeloid Leukemia
  18. 12758
    “…The HPV oncoprotein E7 plays a critical role in the regulation of host immunity to promote the immune escape of HPV and the occurrence of cervical cancer or genital warts. …”
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    HPV E7 inhibits cell pyroptosis by promoting TRIM21-mediated degradation and ubiquitination of the IFI16 inflammasome
  19. 12759
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    LncRNA RP11-620J15.3 promotes HCC cell proliferation and metastasis by targeting miR-326/GPI to enhance glycolysis
  20. 12760
    “…In comparisons of cell treatments with rSAA1 or rSAA3, rSAA3 significantly up-regulated the mRNA expression of mucin 2 (MUC2), a major component of the mucus layer of the intestines that acts as an epithelial cell barrier against pathogens, while MUC2 mRNA expression was not significantly increased by E. coli and LPS. …”
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    Up-Regulation of MUC2 Mucin Expression by Serum Amyloid A3 Protein in Mouse Colonic Epithelial Cells
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