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  1. 12781
    “…The ‘phosphocreatine shuttle’ hypothesis states that mitochondrial and cytosolic CK plays a pivotal role in the transport of high-energy phosphate (HEP) groups from mitochondria to myofibrils in contracting muscle. …”
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    Analyzing the Functional Properties of the Creatine Kinase System with Multiscale ‘Sloppy’ Modeling
  2. 12782
    “…The NMDAR plays a critical role in the development of pain sensitization induced by nerve injury. …”
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    Nitrous oxide persistently alleviates pain hypersensitivity in neuropathic rats: A dose-dependent effect
  3. 12783
    “…Leydig cells contain significant amounts of constitutively produced steroidogenic acute regulatory protein (STAR; STARD1). Hormone-induced STAR plays an essential role in inducing the transfer of cholesterol into the mitochondria for hormone-dependent steroidogenesis. …”
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    Role of Constitutive STAR in Leydig Cells
  4. 12784
    “…This passive oxide thin film not only acted as a protecting layer against the device degradation but also induced a strong n-doping onto MoS(2), which permitted a facile method of detection in MoS(2) FET-based sensors using a low-power mode chemiresistive I-V measurement at zero gate voltage (V(gate) = 0 V). …”
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    Effect of Al(2)O(3) Passive Layer on Stability and Doping of MoS(2) Field-Effect Transistor (FET) Biosensors
  5. 12785
    por Fan, Ping, Jordan, V. Craig
    Publicado 2022
    “…Specifically, PERK plays a critical role in induction of apoptosis whereas IRE1α and ATF6 are involved in the endoplasmic reticulum stress-associated degradation (ERAD) of PI3K/Akt/mTOR pathways. …”
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    PERK, Beyond an Unfolded Protein Response Sensor in Estrogen-Induced Apoptosis in Endocrine-Resistant Breast Cancer
  6. 12786
    por Nie, Lili, Zou, Hui, Ma, Chi, Wang, Xiaoke
    Publicado 2022
    “…CONCLUSION: miR-223-3p plays an inhibitory role in ONG development by regulating NLRP3 to inhibit the proliferation of ONG cells and promote apoptosis.…”
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    miR-223-3p Regulates NLRP3 to Inhibit Proliferation and Promote Apoptosis of ONG Cells
  7. 12787
    “…In this report, we investigate whether A20 also acts as a tumor suppressor in a model of colitis-associated cancer. …”
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    A20 Restricts NOS2 Expression and Intestinal Tumorigenesis in a Mouse Model of Colitis-Associated Cancer
  8. 12788
    “…Salivary glands secrete saliva, a mixture of proteins and fluids, which plays an extremely important role in the maintenance of oral health. …”
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    TRP Channel Involvement in Salivary Glands—Some Good, Some Bad
  9. 12789
    “…In tomato (Solanum lycopersicum), there are at least three SlMLO (Mildew resistance Locus O) genes acting as susceptibility genes for the powdery mildew disease caused by Oidium neolycopersici, namely SlMLO1, SlMLO5 and SlMLO8. …”
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    Discovery and Characterization of a Novel Tomato mlo Mutant from an EMS Mutagenized Micro-Tom Population
  10. 12790
    “…The mitogen-activated protein kinase (MAPK) cascade plays pivotal roles in diverse signalling pathways related to plant development and stress responses. …”
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    Cloning and molecular characterization of a mitogen-activated protein kinase gene from Poncirus trifoliata whose ectopic expression confers dehydration/drought tolerance in transgenic tobacco
  11. 12791
    “…Hyaluronic acid (HA) plays a fundamental role in cell polarity and hydrodynamic processes, affording significant modulation of proliferation, migration, morphogenesis and senescence, with deep implication in the ability of stem cells to execute their differentiating plans. …”
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    REAC technology and hyaluron synthase 2, an interesting network to slow down stem cell senescence
  12. 12792
    “…Direct acting antivirals against hepatitis C virus (HCV) have markedly improved cure rates in the past few years. …”
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    Glycogen synthase kinase 3β inhibitors prevent hepatitis C virus release/assembly through perturbation of lipid metabolism
  13. 12793
    “…Notably, the moxibustion played an important role in CAG treatment mainly by regulating energy metabolism in serum, while main acting site of electro-acupuncture treatment was nervous system in stomach and brain. …”
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    Comparative metabolomics study on therapeutic mechanism of electro-acupuncture and moxibustion on rats with chronic atrophic gastritis (CAG)
  14. 12794
    “…The in vivo and in vitro results showed that acting through histamine 1 receptor, histamine increased miR-206 and miR-216b, which worked in concert to target to Atg13, resulting in the reduction of autophagy activation under hypoxia and AMI condition. …”
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    Histamine deficiency aggravates cardiac injury through miR-206/216b-Atg13 axis-mediated autophagic-dependant apoptosis
  15. 12795
    “…Cosmc is ubiquitously expressed and acts as a specific molecular chaperone assisting the folding and stability of core 1 synthase. …”
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    Loss of complex O-glycosylation impairs exocrine pancreatic function and induces MODY8-like diabetes in mice
  16. 12796
    “…Bile acid synthesis plays a key role in regulating whole body cholesterol homeostasis. …”
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    An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis
  17. 12797
    “…Furthermore, the use of negative coping strategy plays a potential intermediating role in the stress-related increase in hostility, while social support acts as a buffer in hostility in the general population under high stress. …”
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    Impact of the COVID-19 pandemic on mental health in the general Chinese population: Changes, predictors and psychosocial correlates
  18. 12798
    “…Logistic regression analysis detected that after adjusting for major confounders, NLR remained independently associated with depression after ICH (OR = 2.25, 95% CI: 1.45–3.49, P < 0.001). Moreover, NLR acted as the optimal variable for prediction, with the optimal predictive threshold of 4.53 in ROC analysis. …”
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    Elevated Neutrophil-to-Lymphocyte Ratio Predicts Depression After Intracerebral Hemorrhage
  19. 12799
    “…Moreover, analysis of purinergic P2X(2) and P2X(3) receptor-deficient mice indicated that ATP signaling plays a pivotal role in the LPS-induced activation of L6–S1 spinal neurons through the bladder afferent pathway, resulting in rapid onset of the enhanced micturition reflex. …”
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    Bladder urothelium converts bacterial lipopolysaccharide information into neural signaling via an ATP-mediated pathway to enhance the micturition reflex for rapid defense
  20. 12800
    “…The epithelial-to-mesenchymal transition (EMT) plays a critical role during normal development and in cancer progression. …”
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    Identification of EMT signaling cross-talk and gene regulatory networks by single-cell RNA sequencing
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