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12861por Woodard, Amber, Barbery, Brandon, Wilkinson, Reid, Strozyk, Jonathan, Milner, Mathew, Doucette, Patrick, Doran, Jarred, Appleby, Kendra, Atwill, Henry, Bell, Wade E., Turner, James E.Enlace del recurso
Publicado 2019
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12862“…Neuroblastic tumours synthesize various neuropeptides acting as neuromodulators. Previous studies suggested that galanin plays a role in sympathetic tissue where it could be involved in differentiation and development. …”
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12863por Dion, Sébastien P., Béliveau, François, Morency, Louis-Philippe, Désilets, Antoine, Najmanovich, Rafaël, Leduc, Richard“…TMPRSS6, also known as matriptase-2, is a type II transmembrane serine protease that plays a major role in iron homeostasis by acting as a negative regulator of hepcidin production through cleavage of the BMP co-receptor haemojuvelin. …”
Publicado 2018
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12864B7-H7 (HHLA2) inhibits T-cell activation and proliferation in the presence of TCR and CD28 signalingpor Rieder, Sadiye Amcaoglu, Wang, Jingya, White, Natalie, Qadri, Ariful, Menard, Catherine, Stephens, Geoffrey, Karnell, Jodi L., Rudd, Christopher E., Kolbeck, Roland“…This inhibitory activity was comparable to that observed with PD-L1. Finally, in physiological assays using T cells and APCs, blockade of B7-H7 enhanced T-cell activation and proliferation, demonstrating that this ligand acts as a break signal. …”
Publicado 2020
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12865por Zhao, Senlin, Guan, Bingjie, Mi, Yushuai, Shi, Debing, Wei, Ping, Gu, Yanzi, Cai, Sanjun, Xu, Ye, Li, Xinxiang, Yan, Dongwang, Huang, Mingzhu, Li, Dawei“…Glycolysis plays a crucial role in reprogramming the metastatic tumor microenvironment. …”
Publicado 2021
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12866“…RESULTS: The results of Study 1 showed that the closer the PD was, the higher the fear was. …”
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12867por Gong, Longyuan, Cui, Danrui, Liu, Dian, Shen, Xiao, Pan, Hui, Xiong, Xiufang, Zhao, Yongchao“…F-box and WD repeat domain containing 7 (FBXW7) acts as a substrate receptor of SKP1-CUL1-F-box (SCF) E3 ubiquitin ligase and plays crucial roles in the regulation of several cellular processes, including cell growth, division, and differentiation, by targeting diverse key regulators for degradation. …”
Publicado 2022
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12868por Choi, Heekyoung, Heo, Sojeong, Lee, Seonae, Kim, Ka Young, Lim, Jong Hyeon, Jung, Sung Ho, Lee, Shim Sung, Miyake, Hiroyuki, Lee, Jin Yong, Jung, Jong Hwa“…Interestingly, upon addition of AgNO(3) (0.5–1.3 equiv.) to the d-L1 solution, it generated the aggregate I composed of the d-L1AgNO(3) complex (d-L1 : Ag(+) = 1 : 1) as the kinetic product with a spherical structure. …”
Publicado 2019
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12869por Xue, Qian, Yan, Ding, Chen, Xi, Li, Xiaofen, Kang, Rui, Klionsky, Daniel J., Kroemer, Guido, Chen, Xin, Tang, Daolin, Liu, Jinbao“…Conversely, exogenous copper increases GPX4 ubiquitination and the formation of GPX4 aggregates by directly binding to GPX4 protein cysteines C107 and C148. TAX1BP1 (Tax1 binding protein 1) then acts as an autophagic receptor for GPX4 degradation and subsequent ferroptosis in response to copper stress. …”
Publicado 2023
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12870por Zhao, Zhixing, Meng, Guanghua, Zamin, Imran, Wei, Tao, Ma, Dongdi, An, Lizhe, Yue, Xiule“…The characteristics, motif compositions, and evolutionary relationships of the TIFY proteins, as well as the gene structures, cis-acting elements, and synteny of the TIFY genes, are discussed in detail. …”
Publicado 2023
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12871por Zhang, Jiangtao, Wang, Hongjie, Yu, Yanjiang, Zheng, Kaidi, Zhou, Zhixiang, Jiang, Jinlong“…The joint form plays a vital role in the rapid assembly of precast bridge decks for steel–concrete composite bridges. …”
Publicado 2023
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12872“…With policy bibliometric analysis and social network analysis, in each field of policies, its policy networks can be drawn, with statistic of policies released separately, in order to comprehensively analyse the features of NEVs policy making. It is found that: (1) The structure of policy system is balanced among four fields of NEVs policies in China, though with a bias towards Consumption & Promotion, Exploration & Manufacture. (2) Policy makers in all four fields of NEVs policies preferred slightly to formulate policies jointly, rather than acting alone. …”
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12873por Kim, Hyo Young, Goo, Jung Hyun, Joo, Yeon Ah, Lee, Ha Yoen, Lee, Se Mi, Oh, Chang Taek, Ahn, Soo Mi, Kim, Nam-Hoon, Hwang, Jae Sung“…Accordingly, we suggest that NDGA acts as a PAR2 antagonist and may be a possible therapeutic agent for atopic dermatitis.…”
Publicado 2012
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12874por Rishikaysh, Pisal, Dev, Kapil, Diaz, Daniel, Qureshi, Wasay Mohiuddin Shaikh, Filip, Stanislav, Mokry, Jaroslav“…NF-κB regulates the Wnt pathway and acts as a signal mediator by upregulating the expression of Shh ligand. …”
Publicado 2014
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12875“…Indeed, mounting evidence implicates splicing factors in signal transduction of the abscisic acid (ABA) phytohormone, which plays pivotal roles in the response to various abiotic stresses. …”
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12876por Brotosudarmo, Tatas Hardo Panintingjati, Limantara, Leenawaty, Setiyono, Edi, Heriyanto“…It also acts as a metal chelator and converts metal prooxidants into harmless molecules. …”
Publicado 2020
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12877por Ferreira-Silva, Joana, Aires, Inês D., Boia, Raquel, Ambrósio, António Francisco, Santiago, Ana Raquel“…Adenosine, acting on adenosine receptors, is a crucial modulator of microglia phenotype. …”
Publicado 2020
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12878por Lauria, Antonino, Martorana, Annamaria, La Monica, Gabriele, Mannino, Salvatore, Mannino, Giuseppe, Peri, Daniele, Gentile, Carla“…The cell division cycle 25 (Cdc25) protein family plays a crucial role in controlling cell proliferation, making it an excellent target for cancer therapy. …”
Publicado 2021
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12879por Rochette, Luc, Dogon, Geoffrey, Zeller, Marianne, Cottin, Yves, Vergely, Catherine“…Serum levels of GDF15 are also increased by aging and in response to cellular stress and mitochondrial dysfunction. It acts as an inflammatory marker and plays a role in the pathogenesis of cardiovascular diseases, metabolic disorders, and neurodegenerative processes. …”
Publicado 2021
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12880“…(1) Background: Various investigations have confirmed that burnout prevails in intensive and demanding contemporary working environments. …”
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