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  1. 1281
    “…p21 is a potent cyclin-dependent kinase inhibitor that plays a role in promoting G1 cell cycle arrest and cellular senescence. …”
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    p53-Independent regulation of p21Waf1/Cip1 expression and senescence by PRMT6
  2. 1282
    “…Our data demonstrate that SphK1 acts as a downstream effector of IGF-1 and plays a critical role in IGF-1-induced EMT, cell migration and paclitaxel resistance of A549 cells, suggesting that SphK1 might be a potential therapeutic target for NSCLC.…”
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    SphK1 functions downstream of IGF-1 to modulate IGF-1-induced EMT, migration and paclitaxel resistance of A549 cells: A preliminary in vitro study
  3. 1283
    “…DNA damage plays a key role in various biological processes involved in malignant disease, the role of the DNA damage repair gene EME1 (essential meiotic structure-specific endonuclease 1) in gastric cancer (GC) development is unknown. …”
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    Essential meiotic structure-specific endonuclease1 (EME1) promotes malignant features in gastric cancer cells via the Akt/GSK3B/CCND1 pathway
  4. 1284
    “…Casein kinase 1 (CK1) plays central roles in various signal transduction pathways and performs many cellular activities. …”
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    A CK1 FRET biosensor reveals that DDX3X is an essential activator of CK1ε
  5. 1285
    “…In this case, the SCD-1 gene was thought to act as a tumor suppressor. …”
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    Downregulation of Stearoyl-CoA Desaturase 1 (SCD-1) Promotes Resistance to Imatinib in Chronic Myeloid Leukemia
  6. 1286
    “…The Ser/Thr Rho kinase 1 (ROCK1) is known to play major roles in a wide range of cellular activities, including those involved in tumor metastasis and apoptosis. …”
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    Identification of ROCK1 kinase as a critical regulator of Beclin1 mediated autophagy during metabolic stress
  7. 1287
    “…Type 1 iodothyronine deiodinase (D1) is a crucial enzyme which converts the prohormone thyroxine (T4) into active tri-iodothyronine (T3). …”
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    The Enzymatic Activity of Type 1 Iodothyronine Deiodinase (D1) is Low in Liver Hemangioma: A Preliminary Study
  8. 1288
    “…Locally acting IGF-1 isoform (mIGF-1) helps the heart to recover from toxic injury and from infarct. …”
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    Local IGF-1 isoform protects cardiomyocytes from hypertrophic and oxidative stresses via SirT1 activity
  9. 1289
    “…PU.1-deficient mice show a complete loss of microglia, indicating that PU.1 plays a pivotal role in microgliogenesis. …”
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    A Comprehensive Profile of ChIP-Seq-Based PU.1/Spi1 Target Genes in Microglia
  10. 1290
    “…The GIRK blocker tertiapin‐Q did not impair galanin‐mediated GLP‐1 inhibition. CONCLUSIONS AND IMPLICATIONS: Galanin, acting via the GAL(1) receptor and G(i)‐coupled signalling in L and K cells, is a potent inhibitor of GLP‐1 and GIP secretion. …”
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    Galanin inhibits GLP‐1 and GIP secretion via the GAL(1) receptor in enteroendocrine L and K cells
  11. 1291
    “…BACKGROUND: Nucleosome assembly protein 1-like 1 (NAP1L1) is highly expressed in various types of cancer and plays an important role in carcinogenesis, but its specific role in tumor development and progression remains largely unknown. …”
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    NAP1L1 promotes tumor proliferation through HDGF/C-JUN signaling in ovarian cancer
  12. 1292
    “…TRPA1 antagonists acting peripherally are likely to be optimal for attenuating primary hyperalgesia (such as inflammation-induced sensitization of peripheral nerve terminals), while centrally acting TRPA1 antagonists are expected to be optimal for attenuating pain conditions in which central amplification of transmission plays a role (such as secondary hyperalgesia and tactile allodynia caused by various types of peripheral injuries). …”
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    TRPA1 Antagonists for Pain Relief
  13. 1293
    “…TRPA1 acts as a polymodal receptor for the perceiving of irritating chemicals, cold, heat, and mechanical sensations in various animal species. …”
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    The role of TRPA1 channels in thermosensation
  14. 1294
    por Kershner, Leah, Welshhans, Kristy
    Publicado 2017
    “…RACK1 also plays an important role at focal adhesions, where it acts to regulate cell migration. …”
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    RACK1 regulates neural development
  15. 1295
    “…Although the modes of action of GKN1 have not been clearly described, recent limited evidence suggests that GKN1 acts as a gastric-specific tumor suppressor. …”
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    The Role of Gastrokine 1 in Gastric Cancer
  16. 1296
    “…Increasing evidence has indicated that mitochondrial reactive oxygen species (ROS) play critical roles in mechanical stress-induced lumbar degenerative disc disease (DDD). …”
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    Programmed NP Cell Death Induced by Mitochondrial ROS in a One-Strike Loading Disc Degeneration Organ Culture Model
  17. 1297
    por Snodgrass, HR, Wilson, DB, Bosma, MJ
    Publicado 1981
    “…A population of suppressor T cells capable of inducing chronic Igh-1(b) suppression was demonstrated by rosetting procedures to possess Igh-1(b)-specific receptors, a result interpreted as indicating that suppressor T cells may act directly upon allotype-bearing B cells. …”
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    T lymphocytes specific for immunoglobulin allotype. I. Igh- 1(b)-specific T cells demonstrated by suppression in vivo and cytotoxicity in vitro
  18. 1298
    “…It has been also explored that IF1 may rather act as a modulator of other molecules more significantly involved in angiogenesis, especially apolipoprotein A1 on which the largest effect could be observed. …”
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    The potential role of mitochondrial ATP synthase inhibitory factor 1 (IF1) in coronary heart disease: a literature review
  19. 1299
    “…CONCLUSIONS: These changes in the interaction derived from the phosphorylation state of NuMA1 suggest that phosphorylation can act as subtle mechanism of temporal and spatial regulation of the complex 4.1R-NuMA1 and therefore of the processes where both proteins play a role.…”
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    NMR characterisation of the minimal interacting regions of centrosomal proteins 4.1R and NuMA1: effect of phosphorylation
  20. 1300
    “…Wnt1 inducible signaling pathway protein-1 (WISP1) may play an important role in promoting carcinogenesis. …”
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    Tp53 Mutation Inhibits Ubiquitination and Degradation of WISP1 via Down-Regulation of Siah1 in Pancreatic Carcinogenesis
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