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  1. 13001
    “…The 37/67 kDa laminin receptor (LAMR) is a multifunctional protein, acting as an extracellular receptor, localizing to the nucleus, and playing roles in rRNA processing and ribosome assembly. …”
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    Extraribosomal functions associated with the C terminus of the 37/67 kDa laminin receptor are required for maintaining cell viability
  2. 13002
    “…The TGF-β homolog Decapentaplegic (Dpp) acts as a secreted morphogen in the Drosophila wing disc, and spreads through the target tissue in order to form a long range concentration gradient. …”
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    Formation of the Long Range Dpp Morphogen Gradient
  3. 13003
    “…Despite the significant role that is likely to be played by genes that control cell division in the elaboration of plant architecture, functional analysis of this family by forward and reverse genetics has been hampered by genetic redundancy. …”
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    TCP14 and TCP15 affect internode length and leaf shape in Arabidopsis
  4. 13004
    “…These results also strengthen the idea that the 5-HT(7) receptor plays a role in thermoregulation, but by acting in concert with other receptors.…”
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    Assessment of 5-HT(7) Receptor Agonists Selectivity Using Nociceptive and Thermoregulation Tests in Knockout versus Wild-Type Mice
  5. 13005
    “…While waiting for a safe and effective vaccine to be made available, new promising direct-acting antiviral (DAA) drugs offer a better therapeutic scenario than in the past even for the poor responder genotypes 1 and 4, provided that effective screening and care is offered. …”
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    Chronic HCV infection: epidemiological and clinical relevance
  6. 13006
    por Sharma, Neha, Sharma, Dhruva
    Publicado 2015
    “…It is marketed under the trade name “Kerydin.” It acts by inhibiting protein synthesis in the fungus. …”
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    An upcoming drug for onychomycosis: Tavaborole
  7. 13007
    por Du, Yi, Tang, Gang, Yuan, Weijie
    Publicado 2020
    “…Previous studies have shown that butyrate plays a protective role in diabetic nephropathy (DN); however, the exact mechanism remains unclear. …”
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    Suppression of HDAC2 by sodium butyrate alleviates apoptosis of kidney cells in db/db mice and HG-induced NRK-52E cells
  8. 13008
    “…Recently, various studies have shown that angiotensin-converting enzyme 2 (ACE2) acts as the “doorknob” that can be bound by the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which conduces to its entrance to the host cells, and plays an important role in corona virus disease 2019 (COVID-19). …”
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    Drug screening and development from the affinity of S protein of new coronavirus with ACE2
  9. 13009
    “…Here, using Drosophila as a model organism, we have defined a role for protein tyrosine phosphatase 61F (PTP61F) (orthologue of mammalian PTP1B and TCPTP) in the initiation and progression of epithelial cancers. …”
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    PTP61F Mediates Cell Competition and Mitigates Tumorigenesis
  10. 13010
    “…A single cough is simulated for particle sizes 1, 10, [Formula: see text] , with motorbike speeds [Formula: see text]. …”
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    Exposure risk analysis of COVID-19 for a ride-sharing motorbike taxi
  11. 13011
    “…Altogether, our results suggest that the crucial role played by the pyrD gene in AIEC virulence, and the presence of structural differences between E. coli and human DHOD allowing for the design of specific inhibitors, make E. coli DHOD a promising target for therapeutical strategies aiming at counteracting chronic inflammation in CD by acting selectively on its bacterial triggers.…”
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    Inactivation of the Pyrimidine Biosynthesis pyrD Gene Negatively Affects Biofilm Formation and Virulence Determinants in the Crohn’s Disease-Associated Adherent Invasive Escherichia coli LF82 Strain
  12. 13012
    “…Catfishing raises questions about the nature of the human self and the role it plays in deception. Understanding how patients use the internet may provide insight into how personality acts on a stage of total anonymity. …”
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    YOU’VE BEEN CATFISHED: An exploration of social deception on online platforms
  13. 13013
    “…In addition, we extend our baseline model to identify mutations whose fitness exhibits strong dependence on vaccination status as well as pairwise interaction effects, i.e. epistasis. Strikingly, both these analyses point to the pivotal role played by the N501 residue in the Spike protein. …”
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    Inferring selection effects in SARS-CoV-2 with Bayesian Viral Allele Selection
  14. 13014
    “…CONCLUSIONS: Our findings indicate that NAMPT, whose corresponding gene is a direct target of HIF-2α, plays an essential catabolic role in OA pathogenesis and acts as a crucial mediator of osteoarthritic cartilage destruction caused by HIF-2α or DMM surgery.…”
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    NAMPT (visfatin), a direct target of hypoxia-inducible factor-2α, is an essential catabolic regulator of osteoarthritis
  15. 13015
    “…Transwell cell chamber was used to simulate the co-action environment of umbilical cord blood initial T lymphocytes and thyroid papillary carcinoma cells (TPC-1and K1). Compared with human normal thyroid follicular epithelial cell line Nthy-ori 3-1. …”
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    FoxP3 promotes lymph node metastasis in patients with papillary thyroid carcinoma complicated with Hashimoto’s thyroiditis
  16. 13016
    “…CONCLUSIONS: Based on our finding that integrin β1/AKT acted primarily to impart premature senescence to bladder cancer cells cultured in collagen gel, we suggest that integrin β1 might be a feasible target for bladder cancer eradication.…”
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    Blockade of integrin signaling reduces chemotherapy-induced premature senescence in collagen cultured bladder cancer cells
  17. 13017
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    SIX3, a tumor suppressor, inhibits astrocytoma tumorigenesis by transcriptional repression of AURKA/B
  18. 13018
    “…In particular, EBV gp150 inhibits antigen presentation by HLA class I, HLA class II, and the non-classical, lipid-presenting CD1d molecules. …”
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    The Epstein-Barr Virus Glycoprotein gp150 Forms an Immune-Evasive Glycan Shield at the Surface of Infected Cells
  19. 13019
    “…BACKGROUND: Angiogenesis, the formation of blood vessel from pre-existing ones, plays an important role in many pathophysiological diseases, such as cancer. …”
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    Comparative analysis of the effects of opioids in angiogenesis
  20. 13020
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    Direct stimulation of ERBB2 highlights a novel cytostatic signaling pathway driven by the receptor Thr(701) phosphorylation
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