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  1. 13021
    “…The DEAD-box-protein DDX5 is an ATP-dependent RNA helicase that is frequently overexpressed in various cancers and acts as a transcriptional co-activator of several transcription factors, including β-catenin. …”
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    DDX5 promotes proliferation and tumorigenesis of non-small-cell lung cancer cells by activating β-catenin signaling pathway
  2. 13022
    “…Conclusively, expression of ICOS is associated with improved survival in CRC and percentage of ICOS(+)CD4(+) cells acting as Th1 cells in either primary tumor tissue or peripheral blood may be a clinical biomarker for good prognosis of CRC patients.…”
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    The clinical impact of ICOS signal in colorectal cancer patients
  3. 13023
    “…The tumor suppressor TP53 gene (encoding p53) plays an important role in the regulation of tumorigenesis in hepatocellular carcinoma (HCC). …”
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    Δ40p53α suppresses tumor cell proliferation and induces cellular senescence in hepatocellular carcinoma cells
  4. 13024
    “…Recently, a pathway has been suggested in which kisspeptin acts directly on the pituitary to secretion of gonadotropin in mammals. …”
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    Effects of Kiss2 on the Expression of Gonadotropin Genes in the Pituitary of Nile Tilapia (Oreochromis niloticus)
  5. 13025
    “…The natural resistance-associated macrophage protein (NRAMP) is widespread in plants and plays critical roles in transporting metal ions, plant growth, and development. …”
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    Systematic Analysis of NRAMP Family Genes in Areca catechu and Its Response to Zn/Fe Deficiency Stress
  6. 13026
    “…Endothelial dysfunction plays a critical role in the progression of type 2 diabetes mellitus (T2DM), leading to cardiovascular complications. …”
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    Whey Improves In Vitro Endothelial Mitochondrial Function and Metabolic Redox Status in Diabetic State
  7. 13027
    “…Recent studies revealed that endoplasmic reticulum (ER) stress played an emerging role of in valve calcification. …”
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    Tanshinone IIA attenuates valvular interstitial cells’ calcification induced by oxidized low density lipoprotein via reducing endoplasmic reticulum stress
  8. 13028
    “…The mammalian target of rapamycin (mTOR) is a serine-threonine kinase that acts as a central mediator of translation and plays important roles in cell growth, synaptic plasticity, cancer, and a wide range of developmental disorders. …”
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    Protein interaction network analysis of mTOR signaling reveals modular organization
  9. 13029
    Publicado 1996
    “…Stimulation of brown adipocytes by their sympathetic innervation plays a major role in body energy homeostasis by regulating the energy- wasting activity of the tissue. …”
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    Purinergic receptor stimulation increases membrane trafficking in brown adipocytes
  10. 13030
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    Evidence for eIF2α phosphorylation-independent effects of GSK2656157, a novel catalytic inhibitor of PERK with clinical implications
  11. 13031
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    The F-actin modulator SWAP-70 controls podosome patterning in osteoclasts
  12. 13032
    “…To inhibit this target, molecular docking was done with various screened inhibitors in which we found Taxifolin acts as common inhibitors for both TryR and Txnpx. …”
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    Dataset generated for Dissection of mechanisms of Trypanothione Reductase and Tryparedoxin Peroxidase through dynamic network analysis and simulations in leishmaniasis
  13. 13033
    “…Vitamin D plays a crucial and very well-known role in regulation of calcium homeostasis and bone metabolism and mineralization. …”
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    Development and Characterization of an Orodispersible Film for Vitamin D3 Supplementation
  14. 13034
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    Landscape-Based Mutational Sensitivity Cartography and Network Community Analysis of the SARS-CoV-2 Spike Protein Structures: Quantifying Functional Effects of the Circulating D614G Variant
  15. 13035
    “…The results of chromatin immunoprecipitation study and luciferase reporter assay further confirmed that SALL4 bound to the promoter of TGF-b1 gene and activated its expression. TGF-β1 knockdown reversed SALL4-mediated promotion of gastric cancer cell motility, migration, and invasion, indicating that TGF-β1 acts as a downstream effector of SALL4. …”
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    SALL4 activates TGF-β/SMAD signaling pathway to induce EMT and promote gastric cancer metastasis
  16. 13036
    “…Here, we show that in this in vitro neuronal model: (i) UPS stimulation early occurs following neurotrophin starvation (-1 h up to -6 h); (ii) NGF controls the steady-state levels of these three presynaptic proteins by acting on coordinate mechanism(s) of dynamic ubiquitin-C-terminal hydrolase 1 (UCHL-1)-dependent (mono)ubiquitin turnover and UPS-mediated protein degradation. …”
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    NGF-Dependent Changes in Ubiquitin Homeostasis Trigger Early Cholinergic Degeneration in Cellular and Animal AD-Model
  17. 13037
    “…BACKGROUND: MKI67 plays a vital role in the tumour microenvironment (TME) and congenital immunity. …”
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    Correlation of MKI67 with prognosis, immune infiltration, and T cell exhaustion in hepatocellular carcinoma
  18. 13038
    “…BACKGROUND: Serine carboxypeptidase-like protein (SCPL) plays an important role in response to stress in plant. …”
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    Genome-wide analysis of serine carboxypeptidase-like protein (SCPL) family and functional validation of Gh_SCPL42 unchromosome conferring cotton Verticillium der Verticillium wilt stress in Gossypium hirsutum
  19. 13039
    “…Developmentally co-regulated genes were dispersed across all Toxoplasma chromosomes, as were tags representing each abundance class, and a variety of biochemical pathways indicating that trans-acting mechanisms likely control gene expression in this parasite. …”
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    The transcriptome of Toxoplasma gondii
  20. 13040
    “…RESULTS: To this end, we ectopically overexpress Noggin and Dkk-1, inhibitors of the BMP and Wnt pathways, respectively, within ventral tissues. …”
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    Genomic analysis of Xenopus organizer function
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