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  1. 13041
    “…It is currently unknown whether in living cells Gβγ acts as a membrane anchor or an allosteric activator of PI3Kγ, and which role its noncatalytic p101 subunit plays in its activation by Gβγ. …”
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  2. 13042
    por Ikezoe, Takayuki
    Publicado 2015
    “…TM expressed on vascular endothelium binds to thrombin, forming a 1:1 complex and acts as an anticoagulant. In addition, the thrombin-TM complex activates protein C to produce APC, which inactivates factors VIIIa and Va in the presence of protein S, thereby inhibiting further thrombin formation. …”
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  3. 13043
    “…We also found that MMP9 expressing CaCo2BBE cells had increased expressions of EGFR and nuclear transcription factor- specificity protein 1 (Sp1). These data imply that MMP9 acts as a tumor suppressor in CAC by sustaining the epithelial mucosal integrity due to the activation of EGFR-Sp1 signaling pathway.…”
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  4. 13044
    “…This VEGF-dependent program includes the activation of aristaless-like homeobox 1 (alx1), a conserved transcriptional regulator of skeletogenic specification across echinoderms and an example of a “terminal selector” gene that controls cell identity. …”
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  5. 13045
    “…Thus, while neutral evolutionary processes may have played a role in the observed patterns of differentiation, UV‐B may have also acted as a selective pressure to differentiate maize landraces in the region. …”
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  6. 13046
    “…These ultrafine spherical metallic glassy particles (∼400 nm in diameter) acted as a micro-milling media for reducing the particle size of MgH(2) powders into submicron particles. …”
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  7. 13047
  8. 13048
    “…Moreover, blockers to pannexin1 channels (probenecid) and P2X3R (A317491) also reduced the actions of BzATP, suggesting that P2X7R stimulation may induce the opening of pannexin1 channels, leading to paracrine ATP release, which could further excite neurons by acting on P2X3Rs. …”
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  9. 13049
  10. 13050
  11. 13051
    “…In the present study, we first examined the change in the calcineurin level, which plays an important role in regulating cytokine release in the nervous system, following lumbar 5 ventral root transection in the rat. …”
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  12. 13052
    “…Mechanistically, SUMOylation acts as signal for PCAF (P300/CBP-associated factor) recruitment at E2F1-target genes. …”
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  13. 13053
    “…The amino acid glycine prevents pyroptotic lysis via unknown mechanisms, without affecting caspase-1 activation or pore formation. Pyroptosis plays a critical role in diverse inflammatory diseases, including sepsis. …”
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  14. 13054
  15. 13055
    “…We found that Chinese medicines played the role of antivirus, anti-inflammation and immunoregulation, and target organs protection in the management of COVID-19 by multiple components acting on multiple targets at multiple pathways. …”
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  16. 13056
    “…L-Canavanine, a conditionally essential non-proteinogenic amino acid analog to L-arginine, plays important roles in cell division, wound healing, immune function, the release of hormones, and a precursor for the synthesis of nitric oxide (NO). …”
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  17. 13057
    “…In this study, we systematically analyzed the functions and the acting mechanisms of LINC02605 in antiviral innate immune response. …”
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  18. 13058
    “…We demonstrated that YKL-40 functioned differently in human IDH1/2 wild-type GSCs. In MGMT promoter-methylated (MGMT-m) GSCs, it acted as a tumor suppressor gene. …”
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  19. 13059
    “…The low frequency, large-scale energy-containing eddies at SFG’s central opening plays a critical role in driving the thin-film vibration. …”
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  20. 13060
    “…Pentraxin 3 (PTX3) plays a key role in the formation of the hyaluronan-rich matrix of the cumulus oophorus surrounding ovulated eggs that is required for successful fertilization and female fertility. …”
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