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13041por Brock, Carsten, Schaefer, Michael, Reusch, H. Peter, Czupalla, Cornelia, Michalke, Manuela, Spicher, Karsten, Schultz, Günter, Nürnberg, Bernd“…It is currently unknown whether in living cells Gβγ acts as a membrane anchor or an allosteric activator of PI3Kγ, and which role its noncatalytic p101 subunit plays in its activation by Gβγ. …”
Publicado 2003
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13042por Ikezoe, Takayuki“…TM expressed on vascular endothelium binds to thrombin, forming a 1:1 complex and acts as an anticoagulant. In addition, the thrombin-TM complex activates protein C to produce APC, which inactivates factors VIIIa and Va in the presence of protein S, thereby inhibiting further thrombin formation. …”
Publicado 2015
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13043por Pujada, Adani, Walter, Lewins, Patel, Aashka, Bui, Tien Anh, Zhang, Zhan, Zhang, Yuchen, Denning, Timothy Luke, Garg, Pallavi“…We also found that MMP9 expressing CaCo2BBE cells had increased expressions of EGFR and nuclear transcription factor- specificity protein 1 (Sp1). These data imply that MMP9 acts as a tumor suppressor in CAC by sustaining the epithelial mucosal integrity due to the activation of EGFR-Sp1 signaling pathway.…”
Publicado 2017
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13044“…This VEGF-dependent program includes the activation of aristaless-like homeobox 1 (alx1), a conserved transcriptional regulator of skeletogenic specification across echinoderms and an example of a “terminal selector” gene that controls cell identity. …”
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13045por Kost, Matthew A., Perales, Hugo, Wijeratne, Saranga, Wijeratne, Asela J., Stockinger, Eric J., Mercer, Kristin L.“…Thus, while neutral evolutionary processes may have played a role in the observed patterns of differentiation, UV‐B may have also acted as a selective pressure to differentiate maize landraces in the region. …”
Publicado 2020
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13046“…These ultrafine spherical metallic glassy particles (∼400 nm in diameter) acted as a micro-milling media for reducing the particle size of MgH(2) powders into submicron particles. …”
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13047por Xu, Bowen, Dan, Wenchao, Zhang, Xiaoxiao, Wang, Heping, Cao, Luchang, Li, Shixin, Li, Jie“…The enrichment predicted USM by acting on RELA, NFKB1, IKBKG, JUN, MAPK1, TP53, and AKT1. …”
Publicado 2022
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13048por Chen, Zhiyong, Zhang, Chi, Song, Xiaodan, Cui, Xiang, Liu, Jing, Ford, Neil C., He, Shaoqiu, Zhu, Guangwu, Dong, Xinzhong, Hanani, Menachem, Guan, Yun“…Moreover, blockers to pannexin1 channels (probenecid) and P2X3R (A317491) also reduced the actions of BzATP, suggesting that P2X7R stimulation may induce the opening of pannexin1 channels, leading to paracrine ATP release, which could further excite neurons by acting on P2X3Rs. …”
Publicado 2022
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13049por Wahlmueller, Marlene, Narzt, Marie-Sophie, Missfeldt, Karin, Arminger, Verena, Krasensky, Anna, Lämmermann, Ingo, Schaedl, Barbara, Mairhofer, Mario, Suessner, Susanne, Wolbank, Susanne, Priglinger, Eleni“…Acting as the largest energy reservoir in the body, adipose tissue is involved in longevity and progression of age-related metabolic dysfunction. …”
Publicado 2022
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13051por Ouyang, Handong, Nie, Bilin, Wang, Peizong, Li, Qiang, Huang, Wan, Xin, Wenjun, Zeng, Weian, Liu, Xianguo“…In the present study, we first examined the change in the calcineurin level, which plays an important role in regulating cytokine release in the nervous system, following lumbar 5 ventral root transection in the rat. …”
Publicado 2016
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13052“…Mechanistically, SUMOylation acts as signal for PCAF (P300/CBP-associated factor) recruitment at E2F1-target genes. …”
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13053“…The amino acid glycine prevents pyroptotic lysis via unknown mechanisms, without affecting caspase-1 activation or pore formation. Pyroptosis plays a critical role in diverse inflammatory diseases, including sepsis. …”
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13054por Hamy, Anne-Sophie, Derosa, Lisa, Valdelièvre, Constance, Yonekura, Satoru, Opolon, Paule, Priour, Maël, Guerin, Julien, Pierga, Jean-Yves, Asselain, Bernard, De Croze, Diane, Pinheiro, Alice, Lae, Marick, Talagrand, Laure-Sophie, Laas, Enora, Darrigues, Lauren, Grandal, Beatriz, Marangoni, Elisabetta, Montaudon, Elodie, Kroemer, Guido, Zitvogel, Laurence, Reyal, Fabien“…Immunosurveillance plays an important role in breast cancer (BC) prognosis and progression, and can be geared by immunogenic chemotherapy. …”
Publicado 2019
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13055“…We found that Chinese medicines played the role of antivirus, anti-inflammation and immunoregulation, and target organs protection in the management of COVID-19 by multiple components acting on multiple targets at multiple pathways. …”
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13056por Mardani-Korrani, Hossein, Nakayasu, Masaru, Yamazaki, Shinichi, Aoki, Yuichi, Kaida, Rumi, Motobayashi, Takashi, Kobayashi, Masaru, Ohkama-Ohtsu, Naoko, Oikawa, Yosei, Sugiyama, Akifumi, Fujii, Yoshiharu“…L-Canavanine, a conditionally essential non-proteinogenic amino acid analog to L-arginine, plays important roles in cell division, wound healing, immune function, the release of hormones, and a precursor for the synthesis of nitric oxide (NO). …”
Publicado 2021
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13057por Xu, Rui, Yu, Shuang-Shuang, Yao, Ran-Ran, Tang, Rong-Chun, Liang, Jia-Wei, Pang, Xuewen, Zhang, Jun“…In this study, we systematically analyzed the functions and the acting mechanisms of LINC02605 in antiviral innate immune response. …”
Publicado 2021
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13058por Chen, Wei-jun, Zhang, Xiang, Han, Hua, Lv, Jian-nan, Kang, En-ming, Zhang, Yu-lian, Liu, Wei-ping, He, Xiao-sheng, Wang, James, Wang, Gui-huai, Yu, Yan-bing, Zhang, Wei“…We demonstrated that YKL-40 functioned differently in human IDH1/2 wild-type GSCs. In MGMT promoter-methylated (MGMT-m) GSCs, it acted as a tumor suppressor gene. …”
Publicado 2020
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13059“…The low frequency, large-scale energy-containing eddies at SFG’s central opening plays a critical role in driving the thin-film vibration. …”
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13060por Ievoli, Elena, Lindstedt, Ragnar, Inforzato, Antonio, Camaioni, Antonella, Palone, Francesca, Day, Anthony J., Mantovani, Alberto, Salvatori, Giovanni, Salustri, Antonietta“…Pentraxin 3 (PTX3) plays a key role in the formation of the hyaluronan-rich matrix of the cumulus oophorus surrounding ovulated eggs that is required for successful fertilization and female fertility. …”
Publicado 2011
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