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  1. 13181
    “…KCNN3 is a neuronal small conductance calcium-activated potassium channel gene that contains two polyglutamine tracts, encoded by polymorphic CAG repeats in the gene. This gene plays a critical role in determining the firing pattern of neurons and acts to regulate intracellular calcium channels. …”
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    Association analysis of a highly polymorphic CAG Repeat in the human potassium channel gene KCNN3 and migraine susceptibility
  2. 13182
    Publicado 1993
    “…The lipid phosphatidylinositol bisphosphate (PIP2) plays a role in cytoskeletal regulation while its hydrolysis products, diacylglycerol and inositol triphosphate, serve as second messengers. …”
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    Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdown
  3. 13183
    “…Our study also revealed that p53-dependent induction of reactive oxygen species acts as a major signal triggering a mito-checkpoint response. …”
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    p53 regulates mtDNA copy number and mitocheckpoint pathway
  4. 13184
    “…The anti-VEGF therapy bevacizumab acts by binding to VEGF and preventing its effects. …”
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    Bevacizumab therapy normalizes the pathological intraocular environment beyond neutralizing VEGF
  5. 13185
    por Chuang, Chia-Hua, Lin, Chun-Liang
    Publicado 2014
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    Synthesizing genetic sequential logic circuit with clock pulse generator
  6. 13186
    “…We find that RNA interference (RNAi)-directed knockdown of APP in B103 rat neuroblastoma cells expressing APP inhibits Ras-ERK signaling and GSK-3 activation, indicating that APP acts upstream of these signal transduction events. …”
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    Activation of Ras-ERK Signaling and GSK-3 by Amyloid Precursor Protein and Amyloid Beta Facilitates Neurodegeneration in Alzheimer’s Disease
  7. 13187
    “…Alternative splicing of pre-mRNAs plays a pivotal role during the establishment and maintenance of human cell types. …”
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    RNA components of the spliceosome regulate tissue- and cancer-specific alternative splicing
  8. 13188
    por Land, Walter Gottlieb
    Publicado 2018
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    Sessile Innate Immune Cells
  9. 13189
    “…So the SfCncC is involved in the Keap1-Nrf2-ARE pathway, acting the same as the transcriptional factor Nrf2 in vertebrate, and plays a role for host cell defense. …”
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    Characterization of the Cap ‘n’ Collar Isoform C gene in Spodoptera frugiperda and its Association with Superoxide Dismutase
  10. 13190
    “…Here, through JEV infection to BV2 microglia and young BALB/c mice, we investigated that CCR2 is highly upregulated after JEV infection and plays a key role in determining microglia activation phenotype and associated with neurotoxic proinflammatory mediators of TNF-α and IFNγ. …”
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    CCR2 Inhibition Reduces Neurotoxic Microglia Activation Phenotype After Japanese Encephalitis Viral Infection
  11. 13191
    “…The plant hormone cytokinin (CK) plays central roles in plant development and throughout plant life. …”
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    Cytokinin Modulates Cellular Trafficking and the Cytoskeleton, Enhancing Defense Responses
  12. 13192
    “…Under ABA and IAA treatment, the expression of the total 20 StMAPK genes revealed that ABA and IAA played an essential role in this defense process. …”
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    Mitogen-Activated Protein Kinase Expression Profiling Revealed Its Role in Regulating Stress Responses in Potato (Solanum tuberosum)
  13. 13193
    “…Lymphangiogenesis occurs in the dental pulp with inflammatory changes as a response to inflammatory stimuli acting on the tooth. If lymphangiogenesis is defined as the development of lymphatic vessels from already existing ones, such a mechanism is possible only when lymphatic vessels are present in healthy teeth. …”
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    Review on the Lymphatic Vessels in the Dental Pulp
  14. 13194
    “…Heavy-metal ATPase (HMA), an ancient family of transition metal pumps, plays important roles in the transmembrane transport of transition metals such as Cu, Zn, Cd, and Co. …”
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    Genome-Wide Characterization of Sedum plumbizincicola HMA Gene Family Provides Functional Implications in Cadmium Response
  15. 13195
    “…As a result, they most often establish latent infections controlled by the arsenal of human host responses that include the chemokine system playing key roles at the interface between tissue homeostasis and immune surveillance. …”
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    The Chemokine System in Oncogenic Pathways Driven by Viruses: Perspectives for Cancer Immunotherapy
  16. 13196
    “…Corticotropin-releasing factor (CRF) signaling in the central nucleus of the amygdala (CeA) plays a critical role in rodent models of excessive alcohol drinking. …”
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    Central amygdala corticotropin-releasing factor neurons promote hyponeophagia but do not control alcohol drinking in mice
  17. 13197
    por Kwon, Youngjoo
    Publicado 2022
    “…More recently, it has been recognized that BPA also binds to the G protein-coupled estrogen receptor and other nuclear receptors, in addition to estrogen receptors, and acts on immune cells, adipocytes, and fibroblasts, potentially modulating the TME. …”
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    Potential Pro-Tumorigenic Effect of Bisphenol A in Breast Cancer via Altering the Tumor Microenvironment
  18. 13198
    “…The small Rho GTPase acts as a molecular switch in eukaryotic signal transduction, which plays a critical role in polar cell growth and vesicle trafficking. …”
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    Transcriptomic Dynamics of Active and Inactive States of Rho GTPase MoRho3 in Magnaporthe oryzae
  19. 13199
    “…SIMPLE SUMMARY: YPEL3 plays an important role in epithelial-mesenchymal transition (EMT) progression, however, its ability to regulate endometrial cell function and EMT during embryo implantation in ruminants remains unclear. …”
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    YPEL3 Negatively Regulates Endometrial Function via the Wnt/β-Catenin Pathways during Early Pregnancy in Goats
  20. 13200
    “…Overall, the data indicate that GADD34 plays a multifunctional role. Under chronic UPR activation, GADD34 acts as a feedback player, dephosphorylating p-eIF2a, although this role does not seem to be critical. …”
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    GADD34 Ablation Exacerbates Retinal Degeneration in P23H RHO Mice
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