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  1. 13261
    “…CONCLUSION: Through the analysis of inter-generic, inter/intra-specific variation and phylogenetic data, it was found that both selection and mutation played an important role in synonymous codon choice in these genes, but they acted inconsistently on the genes, both matK and rbcL. …”
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    In Silico Analyses of Burial Codon Bias Among the Species of Dipterocarpaceae Through Molecular and Phylogenetic Data
  2. 13262
    “…The above results indicated that direct peritoneal resuscitation with pyruvate showed effective protection to ischemia-reperfusion of the spinal cord through activating autophagy via acting on PHD2 and its downstream HIF-1α/BNIP3 pathway.…”
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    Direct Peritoneal Resuscitation with Pyruvate Protects the Spinal Cord and Induces Autophagy via Regulating PHD2 in a Rat Model of Spinal Cord Ischemia-Reperfusion Injury
  3. 13263
    “…In the absence of an agonist, the P2X(7) receptor acts as a scavenger receptor to phagocytose material. …”
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    The P2X(7) Receptor in Microglial Cells Modulates the Endolysosomal Axis, Autophagy, and Phagocytosis
  4. 13264
    “…In contrast, these differences in apoptotic response between WM35 and WM35-R were not seen with the SJSA-1/SN40R2 cell line pair. This is likely due to p53 suppression by overexpressed MDM2 in SJSA-1. …”
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    TP53 mutant cell lines selected for resistance to MDM2 inhibitors retain growth inhibition by MAPK pathway inhibitors but a reduced apoptotic response
  5. 13265
    “…The results obtained reveal that CerK protein expression and the Ceramide/C1P axis are markedly impaired in all experimental models, demonstrating that the CerK/C1P axis plays a crucial role as molecular regulator of SkM mass associated to cancer or corticosteroids. …”
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    Control of Skeletal Muscle Atrophy Associated to Cancer or Corticosteroids by Ceramide Kinase
  6. 13266
    “…In vitro assays identified collagen VI as playing the key role in cell adhesion and invasion. …”
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    Extracellular vesicles stimulate smooth muscle cell migration by presenting collagen VI
  7. 13267
    “…We determined that C9orf72 exists in a complex with SMCR8 and WDR41 and that this complex acts as a GDP/GTP exchange factor for RAB8 and RAB39, 2 RAB GTPases involved in macroautophagy/autophagy. …”
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    The most prevalent genetic cause of ALS-FTD, C9orf72 synergizes the toxicity of ATXN2 intermediate polyglutamine repeats through the autophagy pathway
  8. 13268
    “…Interleukin-18 (IL-18) is a multifunctional cytokine that augments interferon-γ production and acts as an important immunomediator in the development of several types of cancer. …”
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    Interleukin-18 promoter genotype is associated with the risk of nasopharyngeal carcinoma in Taiwan
  9. 13269
    “…These results demonstrate that RGG2 acts as a negative regulator of plant growth and organ size in rice. …”
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    Mutation of RGG2, which encodes a type B heterotrimeric G protein γ subunit, increases grain size and yield production in rice
  10. 13270
    “…NF-κB signaling, acting through NFKB1 dependent canonical and NFKB2 dependent non-canonical pathways plays a critical role in inflammatory and immune responses. …”
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    A Novel Monoallelic Nonsense Mutation in the NFKB2 Gene Does Not Cause a Clinical Manifestation
  11. 13271
    “…The ferric uptake regulator (Fur) plays key roles in the transcription of many genes involved in iron metabolism and non-iron functions. …”
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    Fur Represses Vibrio cholerae Biofilm Formation via Direct Regulation of vieSAB, cdgD, vpsU, and vpsA-K Transcription
  12. 13272
    por Ha, Le Thanh
    Publicado 2022
    “…The COVID-19 pandemic shock first plays the role of shock receiver from other markets. …”
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    Storm after the Gloomy days: Influences of COVID-19 pandemic on volatility of the energy market
  13. 13273
    “…Following this analysis, we scrutinized the available literature on broadly acting anti-angiogenic natural products, with a focus on finding qualitative information on phytochemicals which could inhibit these targets and came up with 10 prototypical phytochemical compounds: (1) oleanolic acid, (2) tripterine, (3) silibinin, (4) curcumin, (5) epigallocatechin-gallate, (6) kaempferol, (7) melatonin, (8) enterolactone, (9) withaferin A and (10) resveratrol. …”
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    Broad targeting of angiogenesis for cancer prevention and therapy
  14. 13274
    “…In in vivo studies, electrical stimulation of the NI induced theta activity in the MS and the entorhinal cortex, which was impaired by intraseptal infusion of an RXFP3 antagonist, R3(BΔ23-27)R/I5, particularly at ~ 20 min post-injection. These findings suggest that the MS plays an important relay function in the NI-induced generation of theta within the entorhinal cortex. …”
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    Nucleus incertus projections to rat medial septum and entorhinal cortex: rare collateralization and septal-gating of temporal lobe theta rhythm activity
  15. 13275
    “…Glycogen synthase-3β (GSK3β) inactivation plays a key role in mediating signaling processes upon reactive oxygen species (ROS) exposure. …”
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    Glycogen synthase kinase-3β modulation of glucocorticoid responsiveness in COPD
  16. 13276
    “…Activation of the PI3K/AKT (phosphatidylinositol-3-kinase/serine/threonine kinase) pathway plays a role in the pathogenesis of HCC and may contribute to determine resistance to sorafenib. …”
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    The PI3K inhibitor copanlisib synergizes with sorafenib to induce cell death in hepatocellular carcinoma
  17. 13277
    “…Heat shock protein 90 (Hsp90) is a molecular chaperone that plays an important role in tumour biology by promoting the stabilisation and activity of oncogenic ‘client’ proteins. …”
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    Solution structure of the Hop TPR2A domain and investigation of target druggability by NMR, biochemical and in silico approaches
  18. 13278
    “…The problem-specific Reynolds number is assumed to be large and acts as the primary perturbation parameter. Four subsequent stages can be identified as playing key roles in the characterization of the incipient laminar–turbulent transition process: due to the action of an adverse pressure gradient, a classical laminar boundary layer is forced to separate marginally (I). …”
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    The triple-deck stage of marginal separation
  19. 13279
    “…The intestinal mucus layer has a dual role in human health constituting a well-known microbial niche that supports gut microbiota maintenance but also acting as a physical barrier against enteric pathogens. …”
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    Role of mucus-bacteria interactions in Enterotoxigenic Escherichia coli (ETEC) H10407 virulence and interplay with human microbiome
  20. 13280
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    The emerging roles of MAPK-AMPK in ferroptosis regulatory network
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