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  1. 13301
    “…IFN plays a pivotal role in HSV-1 infection and suppresses viral replication both in vitro and in vivo. …”
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    pUL36 Deubiquitinase Activity Augments Both the Initiation and the Progression of Lytic Herpes Simplex Virus Infection in IFN-Primed Cells
  2. 13302
    “…It has been proposed that the SUMn plays a role in the modulation of hippocampal theta-frequency; this could occur through direct connections between the SUMn and the hippocampus or through the influence of the SUMn on the MS. …”
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    Supramammillary serotonin reduction alters place learning and concomitant hippocampal, septal, and supramammillar theta activity in a Morris water maze
  3. 13303
    “…BACKGROUND: Crimean–Congo hemorrhagic fever (CCHF) is a potentially fatal disease caused by a tick-borne virus from the Bunyaviridae family. Cytokines plays an important role in the pathogenesis of viral, bacterial, and immunologic diseases. …”
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    Evaluation of Serum TNF-alpha, IL-6, IL-10, and IFN-gamma Levels in Patients with Crimean–Congo Hemorrhagic Fever
  4. 13304
    “…Itch was unaffected in mice deficient for Cysltr1, Trpv1, or mast cells (W(Sh) mice). CysLT(2)R played a role in itch in the MC903 mouse model of chronic itch and dermatitis, but not in models of dry skin or compound 48/80- or Alternaria-induced itch. …”
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    The CysLT(2)R receptor mediates leukotriene C(4)-driven acute and chronic itch
  5. 13305
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    DNA methylation screening after roux-en Y gastric bypass reveals the epigenetic signature stems from genes related to the surgery per se
  6. 13306
    “…Among these, hSCARB-2 was the first receptor revealed to specifically bind to a definite site of the EV-A71 viral capsid and plays an indispensable role during viral entry. It actually acts as the main receptor due to its ability to recognize all EV-A71 strains. …”
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    EV-A71 Mechanism of Entry: Receptors/Co-Receptors, Related Pathways and Inhibitors
  7. 13307
    “…Studies on heart valve development have recently shown that receptor activator of nuclear factor-κB ligand (RANKL) acts during valve remodeling to promote cathepsin K expression. …”
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    Constitutive expression of cathepsin K in the human intervertebral disc: new insight into disc extracellular matrix remodeling via cathepsin K and receptor activator of nuclear factor-κB ligand
  8. 13308
    “…Here we tested the hypothesis that riluzole inhibits pain behaviors by acting on SK channels in the CeA in an arthritis pain model. …”
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    Small-conductance calcium-activated potassium (SK) channels in the amygdala mediate pain-inhibiting effects of clinically available riluzole in a rat model of arthritis pain
  9. 13309
    “…RESULTS: Phylogenetic and network analyses indicated that A. obscuriceps is composed of two major lineages, i.e., China and Japan. Divergence time on both sides of the ECS was estimated to be approximately 1.07 (0.79–1.32) Ma, which was about the same period that the sea level increased. …”
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    Pleistocene sea level fluctuation and host plant habitat requirement influenced the historical phylogeography of the invasive species Amphiareus obscuriceps (Hemiptera: Anthocoridae) in its native range
  10. 13310
    “…Here, we introduce a coupled feedback loop connecting stiffness to the EMT transcription factor ZEB1, which acts via increasing the secretion of LOXL2 that leads to increased cross-linking of collagen fibers in the ECM. …”
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    A Theoretical Approach to Coupling the Epithelial-Mesenchymal Transition (EMT) to Extracellular Matrix (ECM) Stiffness via LOXL2
  11. 13311
    “…BACKGROUND: Recent studies suggest that YKL-40, also called chitinase-3-like-1 protein, has been implicated in the pathogenesis of various inflammatory diseases. …”
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    YKL-40 expression in chronic obstructive pulmonary disease: relation to acute exacerbations and airway remodeling
  12. 13312
    “…Moreover, OX40 blockade significantly reduced the proinflammatory responses and ameliorated arthritis development. CONCLUSIONS: OX40 acts as an alternative costimulator of CD4(+)CD28(−) T cells and plays a pathogenic role in autoimmune arthritic development, suggesting that it is a potential target for immunomodulatory therapy of RA. …”
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    OX40 signaling is involved in the autoactivation of CD4(+)CD28(−) T cells and contributes to the pathogenesis of autoimmune arthritis
  13. 13313
    por Lee, Chang Ho
    Publicado 2008
    “…In membranes, Ptdlns(4,5)P(2) acts as a precursor to second messengers and is itself a main signaling and targeting molecule. …”
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    Phosphoinositides Signaling and Epithelial-to-Mesenchymal Transition: Putative Topic for Basic Toxicological Research
  14. 13314
    “…The wearable IoT device plays a key role in medical applications, and the antenna is a key part of it. …”
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    C-shaped antenna based artificial magnetic conductor structure for wearable IoT healthcare devices
  15. 13315
    “…The MoA models showed that in the autoinflammatory/systemic phases of Still’s disease, in which the innate immunity plays a pivotal role, the IL-1β-neutralizing antibody canakinumab is more efficient than the IL-6 receptor-inhibiting antibody tocilizumab. …”
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    Application of systems biology-based in silico tools to optimize treatment strategy identification in Still’s disease
  16. 13316
    “…The promoter contains WRKY-, MYB-, and other defense-related cis-acting elements. The structural model of the novel PR-10 protein predicted by I-TASSER showed a topology of the Bet v 1 protein family, including a conserved active site and a ligand-binding hydrophobic cavity. …”
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    A novel rubber tree PR-10 protein involved in host-defense response against the white root rot fungus Rigidoporus microporus
  17. 13317
    “…The pseudo-agents represent a physician and delegate, where the physician plays a senior role to the delegate (i.e. treats high acuity patients and acts as a consult for the delegate). …”
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    Simulating an emergency department: the importance of modeling the interactions between physicians and delegates in a discrete event simulation
  18. 13318
    “…Pioglitazone is a thiazolidinedione derivative that acts by improving insulin resistance via the peroxisome proliferator-activated receptor-γ (PPAR-γ) pathway. …”
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    Pioglitazone counteracts the tumor necrosis factor-α inhibition of follicle-stimulating hormone-induced follicular development and estradiol production in an in vitro mouse preantral follicle culture system
  19. 13319
    “…The sympathetic nervous system also plays a critical role in the pathogenesis of acute myocardial infarction and heart failure. …”
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    Radiofrequency Renal Denervation Protects the Ischemic Heart via Inhibition of GRK2 and Increased Nitric Oxide Signaling
  20. 13320
    “…The SPs themselves discussed how they, perhaps unknowingly, acted in accordance with the discourse of the clinical gaze. …”
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    Blurred boundaries: sexuality and power in standardised patients’ negotiations of the physical examination
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