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  1. 13341
    “…However, whether IL-35 plays a role in endotoxin induced hepatitis demands clarification. …”
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    Interleukin-35 Attenuates D-Galactosamine/Lipopolysaccharide-Induced Liver Injury via Enhancing Interleukin-10 Production in Kupffer Cells
  2. 13342
    “…Replication protein A (RPA) plays a critical role in all eukaryotic DNA processing involving single-stranded DNA (ssDNA). …”
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    ssDNA diffuses along replication protein A via a reptation mechanism
  3. 13343
    “…Moreover, the propofol-induced depression of electrical synaptic strength between TRN PV+ neurons was abolished by 9-CPA (100 μM, specific adenylyl cyclase inhibitor), and by KT5720 (1 μM, selective inhibitor of PKA). Our findings indicate that propofol acts on metabotropic GABA(B) receptors, resulting in a depression of electrical synaptic transmission of coupled TRN PV+ neurons, which is mediated by the adenylyl cyclase-cAMP-PKA signaling pathway. …”
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    Effects of Propofol on Electrical Synaptic Strength in Coupling Reticular Thalamic GABAergic Parvalbumin-Expressing Neurons
  4. 13344
    “…Hence, our study demonstrates that WNK3 maintains the “adult” GABAergic inhibitory tone in neurons and plays a role in the morphological development of neurons and excitability.…”
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    WNK3 Maintains the GABAergic Inhibitory Tone, Synaptic Excitation and Neuronal Excitability via Regulation of KCC2 Cotransporter in Mature Neurons
  5. 13345
    “…N6-methyladenosine (m6A) modification of mRNA plays a crucial regulator in regulating the immune microenvironment of BRCA. …”
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    N6-methyladenosine Regulator-Mediated Immune Genes Identify Breast Cancer Immune Subtypes and Predict Immunotherapy Efficacy
  6. 13346
    “…Farmer associations provided resources to tackle various challenges, acting as bridges across multiple support actor groups. …”
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    Untangling the role of social relationships for overcoming challenges in local food systems: a case study of farmers in Québec, Canada
  7. 13347
    “…These results suggest the RAS plays a conserved role in controlling longevity. …”
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    Control of aging by the renin–angiotensin system: a review of C. elegans, Drosophila, and mammals
  8. 13348
    “…BACKGROUND: Endoplasmic reticulum (ER) stress plays an important role in the occurrence and development of various liver diseases. …”
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    Overexpression of HSF2 binding protein suppresses endoplasmic reticulum stress via regulating subcellular localization of CDC73 in hepatocytes
  9. 13349
    “…Furthermore, circRHOBTB3 acts a tumor-suppressive circRNA by repressing metabolic pathways, intracellular ROS production in CRC. …”
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    Tumor-suppressive circRHOBTB3 is excreted out of cells via exosome to sustain colorectal cancer cell fitness
  10. 13350
    “…CTLA4, a receptor that acts as a negative regulator of T cell responses, plays a pivotal role in this process, and genetic variations in CTLA4 have been linked to CRC susceptibility, prognosis, and response to therapy. …”
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    Functional analysis of CTLA4 promoter variant and its possible implication in colorectal cancer immunotherapy
  11. 13351
    “…Inflammation plays a significant role in the occurrence and development of multiple diseases. …”
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    The Anti-Inflammatory Actions and Mechanisms of Acupuncture from Acupoint to Target Organs via Neuro-Immune Regulation
  12. 13352
    “…Uncontrollable inflammatory response acts as a driver of sepsis-associated liver injury (SALI). …”
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    IL-22 ameliorates LPS-induced acute liver injury by autophagy activation through ATF4-ATG7 signaling
  13. 13353
    “…NLRP3 inflammasome plays an important role in the pathogenesis of rheumatoid arthritis (RA). …”
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    RelA/MicroRNA-30a/NLRP3 signal axis is involved in rheumatoid arthritis via regulating NLRP3 inflammasome in macrophages
  14. 13354
    “…However, in the later phase of SCI, the Smad 6 expression decreased by the addition of SB 431,542, suggesting that TGF-β plays a key role in the mediation of Smad 6 expression in this phase. …”
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    MSC secreted extracellular vesicles carrying TGF-beta upregulate Smad 6 expression and promote the regrowth of neurons in spinal cord injured rats
  15. 13355
    “…RESULTS: In septofimbria and hypothalamus, IBA1-positive and IL-1β-positive cell counts increased after NA injection in wild type (WT) mice. …”
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    Microglial activation by microbial neuraminidase through TLR2 and TLR4 receptors
  16. 13356
    “…CONCLUSION: In sepsis, NMU acting through NMUR1 in lung ILC2s initiates the ILC2 activation, which, in turn, promote IL-17A-producing γδ T cell expansion and secretion of IL-17A. …”
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    Neuronal-Activated ILC2s Promote IL-17A Production in Lung γδ T Cells During Sepsis
  17. 13357
    “…These were identified and classified into three groups, and it was found that Group 1 contained the largest number of members. Analysis of cis-acting elements revealed a large number of elements related to jasmonic acid and light response. …”
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    Genome-Wide Identification and Evolution Analysis of the CYP76 Subfamily in Rice (Oryza sativa)
  18. 13358
    “…While sunscreens, predictably, played a crucial role, additional ingredients (i.e., DNA repair enzymes and antioxidants) also acted as vital protective agents for both the cellular genome and proteome, shielding them against UVR-induced damage. …”
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    Exploring the Protective Efficacy of Topical Products for Actinic Keratosis Against Ultraviolet-Induced DNA and Protein Damage: An Experimental, Double-Blind Irradiation Study
  19. 13359
    “…Introduction: The conversion of dietary inorganic nitrate (NO3-) to nitric oxide (NO) is a non-canonical pathway that plays an important role in NO biology, especially under pathological conditions. …”
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    Effects of S-Allylcysteine-Rich Garlic Extract and Dietary Inorganic Nitrate Formula on Blood Pressure and Salivary Nitric Oxide: An Open-Label Clinical Trial Among Hypertensive Subjects
  20. 13360
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    Induction of Tissue Factor Expression in Endothelial Cells by Basic Fibroblast Growth Factor and its Modulation by Fenofibric acid
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