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  1. 13421
    “…BACKGROUND: The tumor microenvironment plays a determinative role in stimulating tumor progression and metastasis. …”
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    S100A4-neutralizing antibody suppresses spontaneous tumor progression, pre-metastatic niche formation and alters T-cell polarization balance
  2. 13422
    “…Using integrated data from six phase 3 studies, we report the safety and efficacy of the 3-direct-acting antiviral (DAA) regimen containing ombitasvir (OBV, an NS5A inhibitor), ritonavir-boosted paritaprevir (PTV/r, an NS3/4A protease inhibitor), and dasabuvir (DSV, an NS5B polymerase inhibitor) with or without ribavirin (RBV) for HCV genotype 1 patients taking concomitant ARAs and PPIs. …”
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    Safety and Efficacy of Ombitasvir/Paritaprevir/Ritonavir Plus Dasabuvir With or Without Ribavirin in HCV-Infected Patients Taking Concomitant Acid-Reducing Agents
  3. 13423
    “…Specific activation of EP4 drives Th17 cell development and promotes EP4 expression in a positive feedback loop in AS but not in RA or PsA. Mechanistically, EP4 acts via upregulation of the interleukin-23 receptor (IL-23R), by suppressing the RORγt inhibitor FoxO1 and by enhancing STAT3 phosphorylation. …”
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    Prostaglandin receptor EP4 expression by Th17 cells is associated with high disease activity in ankylosing spondylitis
  4. 13424
    “…These findings are consistent with the hypothesis that strong divergent selection acting on chemosensory receptor genes plays an important role in the evolution and diversification of insect pheromone systems. …”
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    Rapid evolution of chemosensory receptor genes in a pair of sibling species of orchid bees (Apidae: Euglossini)
  5. 13425
    “…KEY MESSAGE: A dehydration-inducible Arabidopsis CIN-like TCP gene, TCP13, acts as a key regulator of plant growth in leaves and roots under dehydration stress conditions. …”
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    CIN-like TCP13 is essential for plant growth regulation under dehydration stress
  6. 13426
    por Liu, Yang
    Publicado 2023
    “…A previous study confirmed that treatment with eugenol attenuated lung inflammation and improved heart functions in SARS-CoV-2 spike S1-intoxicated mice. In addition to the study, based on a series of public datasets, computational analyses were conducted to characterize the acting targets of eugenol and the functional roles of these targets in COVID-19. …”
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    Integrative network pharmacology and in silico analyses identify the anti-omicron SARS-CoV-2 potential of eugenol
  7. 13427
    “…BACKGROUND: The imaging of somatostatin receptors (SSTRs) plays a significant role in imaging neuroendocrine tumors (NETs). …”
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    Effects of somatostatin analogs on uptake of radiolabeled somatostatin analogs on imaging: a systematic review and meta-analysis
  8. 13428
    “…Introduction: Annexin A2 (AnxA2) plays a critical role in cell transformation, immune response, and resistance to cancer therapy. …”
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    The flavagline FL3 interferes with the association of Annexin A2 with the eIF4F initiation complex and transiently stimulates the translation of annexin A2 mRNA
  9. 13429
    “…We also explored the basis for the inflammatory response elicited by C. jejuni in Sigirr(−/−) mice, focusing on the roles played by Toll-like receptors (TLR) 2 and 4, as these innate receptors were strongly stimulated by C. jejuni. …”
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    A Novel Mouse Model of Campylobacter jejuni Gastroenteritis Reveals Key Pro-inflammatory and Tissue Protective Roles for Toll-like Receptor Signaling during Infection
  10. 13430
    “…Here, we describe a novel tumor-promoting mechanism of IL6, whereby hypoxia-induced IL6 acts as a potent initiator of autophagy in glioblastoma via the phosphorylated (p)-STAT3-MIR155-3p pathway. …”
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    A novel tumor-promoting mechanism of IL6 and the therapeutic efficacy of tocilizumab: Hypoxia-induced IL6 is a potent autophagy initiator in glioblastoma via the p-STAT3-MIR155-3p-CREBRF pathway
  11. 13431
    “…Emerging evidence suggests that hypermethylation of HOXD10 plays an important role in human cancers. However, the biological and clinical impacts of HOXD10 overmethylation and its downstream targets in colorectal cancer remain unknown. …”
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    Restoring HOXD10 Exhibits Therapeutic Potential for Ameliorating Malignant Progression and 5-Fluorouracil Resistance in Colorectal Cancer
  12. 13432
    “…It acts as a tumor suppressor during the early stages of cancer progression. …”
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    Hsa-miR-587 Regulates TGFβ/SMAD Signaling and Promotes Cell Cycle Progression
  13. 13433
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    The role of ubiquitin ligase E3A in polarized contact guidance and rescue strategies in UBE3A-deficient hippocampal neurons
  14. 13434
    por Xing, Yunlong, Li, Kai, Jiao, Yuan, Li, Zinan
    Publicado 2020
    “…The nucleus basalis (NB) acts as a major relay between the reticular activating system and the frontal cortex (FC). …”
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    Propofol Causes Consciousness Loss by Affecting GABA-A Receptor in the Nucleus Basalis of Rats
  15. 13435
    “…In the hPAECs and hPASMCs, we found an increased expression of HO-1 (heme oxygenase-1) and a decreased IFIT3 (interferon-induced proteins with tetratricopeptide repeats 3) (confirmed by Western blotting), allowing us to identify these axes to understand the consequences of KCNK3 dysfunction. …”
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    Proteomic Analysis of KCNK3 Loss of Expression Identified Dysregulated Pathways in Pulmonary Vascular Cells
  16. 13436
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    Genome-wide identification, evolutionary and expression analysis of the cyclin-dependent kinase gene family in peanut
  17. 13437
    “…Structural determination of a number of IL-4 variants together with in vitro binding studies show that IL-4 and its high-affinity receptor subunit IL-4Rα interact via a modular protein-protein interface consisting of three independently-acting interaction clusters. For high-affinity binding of wild-type IL-4 to its receptor IL-4Rα, only two of these clusters (i.e. cluster 1 centered around Glu9 and cluster 2 around Arg88) contribute significantly to the free binding energy. …”
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    A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor
  18. 13438
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    Ecological genomics in Xanthomonas: the nature of genetic adaptation with homologous recombination and host shifts
  19. 13439
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    Evaluation of the two-step treatment with ionic liquids and alkali for enhancing enzymatic hydrolysis of Eucalyptus: chemical and anatomical changes
  20. 13440
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    ERRα suppression enhances the cytotoxicity of the MEK inhibitor trametinib against colon cancer cells
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