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  1. 13441
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    WDR76 degrades RAS and suppresses cancer stem cell activation in colorectal cancer
  2. 13442
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    Cooperation of Dnmt3a R878H with Nras G12D promotes leukemogenesis in knock-in mice: a pilot study
  3. 13443
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    KIAA1429 contributes to liver cancer progression through N6-methyladenosine-dependent post-transcriptional modification of GATA3
  4. 13444
    “…Particularly significant advantages of this µCT-DL approach, are: (i) its reduced experimental variability, due to the fact that each animal acts as its own control and the measured, operator bias-free biomarkers can be quantitatively compared across experiments; (ii) its ability to monitor longitudinally the spatial distribution of fibrotic lesions, thus eliminating potential confounding effects associated with the more severe fibrosis observed in the apical region of the left lung and the compensatory effects taking place in the right lung; (iii) the animal sparing afforded by its non-invasive nature and high reliability; and (iv) the fact that it can be integrated into different drug discovery pipelines with a substantial increase in both the speed and robustness of the evaluation of new candidate drugs. …”
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    A fully automated micro‑CT deep learning approach for precision preclinical investigation of lung fibrosis progression and response to therapy
  5. 13445
    “…BACKGROUND: Social media plays a pivotal role in disseminating news globally and acts as a platform for people to express their opinions on various topics. …”
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    Mining Trends of COVID-19 Vaccine Beliefs on Twitter With Lexical Embeddings: Longitudinal Observational Study
  6. 13446
    “…The results indicated that CcPrdx6 played the role of antioxidant with different mechanisms, i.e., binding to reactive oxygen species and stabilizing membrane fluidity, in livers of hypothermal FW and SW milkfish, respectively.…”
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    The Antioxidant Peroxiredoxin 6 (Prdx6) Exhibits Different Profiles in the Livers of Seawater- and Fresh Water-Acclimated Milkfish, Chanos chanos, upon Hypothermal Challenge
  7. 13447
    “…c-di-AMP is an important second messenger molecule that plays a pivotal role in regulating fundamental cellular processes, including osmotic and cell wall homeostasis in many Gram-positive organisms. …”
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    Inhibition of the Staphylococcus aureus c-di-AMP cyclase DacA by direct interaction with the phosphoglucosamine mutase GlmM
  8. 13448
    “…The use of analgesics and sedatives plays an important role in improving patient outcomes in the intensive care unit (ICU). …”
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    Analysis of trends in usage of analgesics and sedatives in intensive care units of South Korea: A retrospective nationwide population-based study
  9. 13449
    “…The core phenotype of anorexia nervosa (AN) comprises the age and stage dependent intertwining of both its primary and secondary (i.e., starvation induced) somatic and mental symptoms. …”
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    Clinical Trials Required to Assess Potential Benefits and Side Effects of Treatment of Patients With Anorexia Nervosa With Recombinant Human Leptin
  10. 13450
    “…In the brain, D-serine is the primary physiological co-agonist of synaptic NMDARs. Whether D-serine plays a role in the cochlea had remained unexplored. …”
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    Physiopathological Relevance of D-Serine in the Mammalian Cochlea
  11. 13451
    “…Despite the knowledge that the microbiota in our gut plays an essential part in maintaining gut health, their exact functions in gut homeostasis are still unclear. …”
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    Current Treatment Options and Therapeutic Insights for Gastrointestinal Dysmotility and Functional Gastrointestinal Disorders
  12. 13452
    “…GABAergic system disinhibition played an important role in the pathogenesis of remifentanil-induced hyperalgesia (RIH). …”
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    KCC2 receptor upregulation potentiates antinociceptive effect of GABAAR agonist on remifentanil-induced hyperalgesia
  13. 13453
    “…On the other hand, IL-10 is an anti-inflammatory cytokine, acting as a master regulator of inflammation during both African trypanosomiasis and other diseases. …”
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    The Role of MIF and IL-10 as Molecular Yin-Yang in the Modulation of the Host Immune Microenvironment During Infections: African Trypanosome Infections as a Paradigm
  14. 13454
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    Stimulating solidarity to improve knowledge on medications used during pregnancy: A contribution from the ConcePTION project
  15. 13455
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    Novel temporal and spatial patterns of metastatic colonization from breast cancer rapid-autopsy tumor biopsies
  16. 13456
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    miR-30a targets STOX2 to increase cell proliferation and metastasis in hydatidiform moles via ERK, AKT, and P38 signaling pathways
  17. 13457
    por Karwowski, Bolesław T.
    Publicado 2023
    “…The results presented below indicate that 7,8-dihydro-8-oxo-2′-deoxyguanosine plays a significant role in charge transfer through ds-DNA containing CDL and indirectly has an influence on the DNA lesion recognition and repair process. …”
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    (Fapy)dG in the Shadow of (OXO)dG—A Theoretical Study of Clustered DNA Lesions
  18. 13458
    “…The loss of inhbaa also caused a reduction of Vtg receptor-like molecules (e.g., lrp1ab and lrp2a). In summary, the present study provided comprehensive genetic evidence that Bmp15 acts together with the activin-inhibin system in the follicle to control E2 production from the follicle, Vtg biosynthesis in the liver and its uptake by the developing oocytes.…”
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    Rescue of bmp15 deficiency in zebrafish by mutation of inha reveals mechanisms of BMP15 regulation of folliculogenesis
  19. 13459
    por Waples, Robin S.
    Publicado 2023
    “…Variance in reproductive success ([Formula: see text] , with k = number of offspring) plays a large role in determining the rate of genetic drift and the scope within which selection acts. …”
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    Partitioning variance in reproductive success, within years and across lifetimes
  20. 13460
    “…We conclude that p7 functions as a H(+) permeation pathway, acting to prevent acidification in otherwise acidic intracellular compartments. …”
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    Intracellular Proton Conductance of the Hepatitis C Virus p7 Protein and Its Contribution to Infectious Virus Production
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