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  1. 13461
    “…BACKGROUND: Pleistocene climatic oscillations have played a major role in structuring present-day biodiversity. …”
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    Persistence across Pleistocene ice ages in Mediterranean and extra-Mediterranean refugia: phylogeographic insights from the common wall lizard
  2. 13462
    “…BACKGROUND: Vascular endothelial growth factor (VEGF) is a naturally occurring glycoprotein in the body that acts as a growth factor for endothelial cells. It regulates angiogenesis, enhances vascular permeability, and plays a major role in wet age-related macular degeneration. …”
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    Aflibercept in wet AMD: specific role and optimal use
  3. 13463
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    Emu oil offers protection in Crohn’s disease model in rats
  4. 13464
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    Biobanking from the patient perspective
  5. 13465
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    Immunosenescence in aging: between immune cells depletion and cytokines up-regulation
  6. 13466
    “…Next, endocannabinoid signaling that regulates synaptic plasticity is discussed as a key mechanism acting both at hypothalamic and mesolimbic circuits, and affecting both dopamine function and interplay between leptin and ghrelin signaling. …”
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    Hedonic Eating and the “Delicious Circle”: From Lipid-Derived Mediators to Brain Dopamine and Back
  7. 13467
    por Zeng, Zhijun, Yang, Hao, Xiao, Shuai
    Publicado 2018
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    ACTL6A expression promotes invasion, metastasis and epithelial mesenchymal transition of colon cancer
  8. 13468
    “…This combination of eccentric and concentric contractions is the most important type of daily muscle action and plays a significant role in natural locomotion such as walking, running or jumping. …”
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    Cross-Bridges and Sarcomeric Non-cross-bridge Structures Contribute to Increased Work in Stretch-Shortening Cycles
  9. 13469
    “…Background: Bromodomain-containing protein 7 (BRD7) is identified as a transcriptional regulator and plays an important role in the development and progression of various tumors. …”
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    BRD7 inhibits tumor progression by positively regulating the p53 pathway in hepatocellular carcinoma
  10. 13470
    “…Our functional molecular results suggest that ZNF677 acts as a tumor suppressor, mediating its effect by inhibiting AKT phosphorylation. …”
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    Loss of ZNF677 Expression Is an Independent Predictor for Distant Metastasis in Middle Eastern Papillary Thyroid Carcinoma Patients
  11. 13471
    “…OBJECTIVES/GOALS: Nicotinamide adenine dinucleotide (NAD) plays essential roles in energy metabolism and cell signaling pathways. …”
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    4582 NICOTINAMIDE ADENINE DINUCLEOTIDE (NAD) DEPLETION MUST BE SEVERE TO INDUCE CARDIAC DYSFUNCTION AND EVENTUAL FAILURE
  12. 13472
    “…SIMPLE SUMMARY: The epidermal growth factor receptor (EGFR) plays a central role in the tumor microenvironment, through the activation of paracrine and autocrine circuits that promote cancer development and progression. …”
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    The EGFR Signaling Modulates in Mesenchymal Stem Cells the Expression of miRNAs Involved in the Interaction with Breast Cancer Cells
  13. 13473
    “…At 40 ng/ml, glucose uptake diminished on day 1 up to day 3, while ATP accumulation was detected on day 5. …”
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    Human tumor necrosis factor alpha affects the egg-laying dynamics and glucose metabolism of Schistosoma mansoni adult worms in vitro
  14. 13474
    “…In particular, FGF2, likely acting through FGFR1, promoted invasion of C3G-silenced GBM cells. …”
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    C3G downregulation induces the acquisition of a mesenchymal phenotype that enhances aggressiveness of glioblastoma cells
  15. 13475
    “…Addition of recombinant Sfrp2 restored most of these activities, suggesting that Sfrp2 acts as a Wnt agonist. We demonstrate that Sfrp2 plays a role in self-renewal of SSCs and in the recruitment and differentiation of adult SSCs during bone healing. …”
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    Secreted frizzled related-protein 2 (Sfrp2) deficiency decreases adult skeletal stem cell function in mice
  16. 13476
    “…Early diagnosis combined with the appropriate treatment plays an unquestionable significant role in the survival rates and prognosis for head and neck cancer patients. …”
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    The influence of the first coronavirus wave on the two-week-wait head and neck cancer referrals to a London hospital
  17. 13477
    “…BACKGROUND: microRNA-122 (miR-122) is the most abundant and specific miRNA in the liver. It acts as an important tumor suppressor in hepatocellular carcinoma (HCC) through regulating its target genes, but details of its own regulation are largely unknown. …”
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    Upregulation of microRNA-122 by farnesoid X receptor suppresses the growth of hepatocellular carcinoma cells
  18. 13478
    por Wang, Huang-Joe, Lo, Wan-Yu
    Publicado 2018
    “…SB203580 (specific inhibitor of p38) and BIX02189 (specific inhibitor of MEK5) were used to identify bFGF as the main cytoprotective factor acting via p38/MAPK and MEK5-KLF2 pathways. Results: Compared with traditional LSM, the new LSM not only significantly decreased TNF-α-induced intracellular adhesion molecule 1 and plasminogen activator inhibitor type 1 gene expression, but also significantly increased heme oxygenase 1 gene expression. …”
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    Identification of Basic Fibroblast Growth Factor as the Dominant Protector of Laminar Shear Medium from the Modified Shear Device in Tumor Necrosis Factor-α Induced Endothelial Dysfunction
  19. 13479
    “…Recent evidence has indicated that the novel lncRNA LINC01133 plays an important role in cancer progression and metastasis. …”
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    LINC01133 as ceRNA inhibits gastric cancer progression by sponging miR-106a-3p to regulate APC expression and the Wnt/β-catenin pathway
  20. 13480
    “…Meanwhile, adenosine plays an important role in triggering ischemic preconditioning through the activation of the A1 receptor. …”
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    Ticagrelor and preconditioning in patients with stable coronary artery disease (TAPER-S): a randomized pilot clinical trial
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