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  1. 1361
    “…Accumulating evidence suggests that astrocyte-to-neuron lactate shuttle (ANLS) plays a critical role in energy metabolism in neurons, including retinal ganglion cells (RGCs). …”
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    Aqp9 Gene Deletion Enhances Retinal Ganglion Cell (RGC) Death and Dysfunction Induced by Optic Nerve Crush: Evidence that Aquaporin 9 Acts as an Astrocyte-to-Neuron Lactate Shuttle in Concert with Monocarboxylate Transporters To Support RGC Function and Survival
  2. 1362
    “…The most prominent nuclear export receptor is chromosome region maintenance 1 (CRM1), also known as exportin 1 (XPO1). One of its cargo proteins is the prolyl hydroxylase 2 (PHD2) which is involved in the initiation of the degradation of hypoxia-inducible factors (HIFs) under normoxia. …”
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    Selinexor decreases HIF-1α via inhibition of CRM1 in human osteosarcoma and hepatoma cells associated with an increased radiosensitivity
  3. 1363
    “…In conclusion, TRPC1 is widely expressed in the rat heart, including in working cells, Purkinje cells and vascular cells, suggesting that it plays an important role in the heart. …”
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    TRPC1 expression and distribution in rat hearts
  4. 1364
    por Yu, Yan, Tang, Daolin, Kang, Rui
    Publicado 2015
    “…High mobility group box 1 (HMGB1) is a widely-expressed and highly-abundant protein that acts as an extracellular signal upon active secretion by immune cells or passive release by dead, dying, and injured cells. …”
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    Oxidative stress-mediated HMGB1 biology
  5. 1365
    “…SCD1 plays an important role in cancer, promoting cell proliferation and metastasis. …”
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    SCD1, autophagy and cancer: implications for therapy
  6. 1366
    por Wang, Shu-Chao, Hu, Xi-Min, Xiong, Kun
    Publicado 2022
    “…However, we know very little about how Pin1-associated pathways might play a role in regulated cell death. …”
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    The regulatory role of Pin1 in neuronal death
  7. 1367
    “…BACKGROUND: Various evolutionary models have been proposed to interpret the fate of paralogous duplicates, which provides substrates on which evolution selection could act. In particular, domestication, as a special selection, has played important role in crop cultivation with divergence of many genes controlling important agronomic traits. …”
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    Duplication and independent selection of cell-wall invertase genes GIF1 and OsCIN1 during rice evolution and domestication
  8. 1368
    “…In recent years, GPBAR1 has been thought to play an important role in bile homeostasis, metabolism and inflammation. …”
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    Therapeutic Opportunities of GPBAR1 in Cholestatic Diseases
  9. 1369
    por Xu, Li-Di, Öhman, Marie
    Publicado 2018
    “…Editing of adenosine to inosine (A-to-I) in double-stranded RNA, catalyzed by adenosine deaminases acting on RNA (ADARs), is one dynamic modification that in a combinatorial manner can give rise to a very diverse transcriptome. …”
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    ADAR1 Editing and its Role in Cancer
  10. 1370
    “…In addition, we introduce the latest potential therapeutic strategies that inhibit or activate NEDD4-1 activity using small molecules. NEDD4-1 likely acts as a novel drug target or diagnostic marker in the battle against cancer.…”
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    The many substrates and functions of NEDD4-1
  11. 1371
    “…A dual-luciferase reporter assay identified that lncRNA-Six1 overlaps the Six1 proximal promoter. In lncRNA-Six1, a micropeptide of about 7.26 kDa was found to play an important role in the lncRNA-Six1 in cis activity. …”
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    LncRNA-Six1 Encodes a Micropeptide to Activate Six1 in Cis and Is Involved in Cell Proliferation and Muscle Growth
  12. 1372
    “…Together, our findings provide evidence that HMGA1, by regulating PDX-1- and MafA-induced transactivation of the INS gene promoter, plays a critical role in pancreatic beta-cell function and insulin production.…”
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    Cooperation between HMGA1, PDX-1, and MafA is Essential for Glucose-Induced Insulin Transcription in Pancreatic Beta Cells
  13. 1373
    “…C1qTNF1 may act as a key mediator in the integration of lipid metabolism and inflammatory responses in macrophages. …”
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    Elevated Plasma Levels of C1qTNF1 Protein in Patients with Age-Related Macular Degeneration and Glucose Disturbances
  14. 1374
    “…Annotation of HUVEC microarray data revealed that seven miRNAs, including miR-320a, were upregulated after knockdown of MALAT1 expression in HUVECs. MALAT1 was shown to reciprocally interact with miR-320a, i.e., expression of one negatively regulated levels of the other, whereas knockdown of MALAT1 expression promoted miR-320a levels. …”
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    Knockdown of MALAT1 expression inhibits HUVEC proliferation by upregulation of miR-320a and downregulation of FOXM1 expression
  15. 1375
    “…Mxi1 is a Mad family member that plays a role in cell proliferation and differentiation. …”
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    Mxi1 inhibits the proliferation of U87 glioma cells through down-regulation of cyclin B1 gene expression
  16. 1376
    “…The levels of all other molecular species of PC, PE, PS and PA measured in the brain and liver were very similar between LPIAT1(−/−) and LPIAT1(+/+) samples. These results suggest LPIAT1 activity plays a non-redundant role in maintaining physiological levels of PtdIns within an active deacylation/reacylation cycle in mouse tissues. …”
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    Lysophosphatidylinositol-Acyltransferase-1 (LPIAT1) Is Required to Maintain Physiological Levels of PtdIns and PtdInsP(2) in the Mouse
  17. 1377
    “…T Cell Leukemia/Lymphoma 1A is expressed during B-cell differentiation and, when over-expressed, acts as an oncogene in mouse (Tcl1a) and human (TCL1A) B-cell chronic lymphocytic leukemia (B-CLL) and T-cell prolymphocytic leukemia (T-PLL). …”
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    T Cell Leukemia/Lymphoma 1A is essential for mouse epidermal keratinocytes proliferation promoted by insulin-like growth factor 1
  18. 1378
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    Mimicking the Electron Transport Chain and Active Site of [FeFe] Hydrogenases in One Metal–Organic Framework: Factors That Influence Charge Transport
  19. 1379
    “…Consistent with this interaction, blockers of the permeability transition pore complex (PTPC) inhibited PB1-F2-induced mitochondrial permeabilization. Based on our findings, we propose a model whereby the proapoptotic PB1-F2 protein acts through the mitochondrial PTPC and may play a role in the down-regulation of the host immune response to infection.…”
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    Influenza Virus PB1-F2 Protein Induces Cell Death through Mitochondrial ANT3 and VDAC1
  20. 1380
    “…Mechanistically, CHAF1A acted as a co-activator in the Wnt pathway. …”
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    CHAF1A interacts with TCF4 to promote gastric carcinogenesis via upregulation of c-MYC and CCND1 expression
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