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  1. 1381
    “…Our results indicated that Syb-prII-1 could provide a potential treatment for TN by acting on the Nav1.8 target.…”
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    Scorpion Neurotoxin Syb-prII-1 Exerts Analgesic Effect through Nav1.8 Channel and MAPKs Pathway
  2. 1382
    “…Finally, we demonstrated that MALAT1 promoted ZHX1 expression via acting as a competing endogenous RNA by sponging miR-199a. …”
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    Blocking lncRNA MALAT1/miR-199a/ZHX1 Axis Inhibits Glioblastoma Proliferation and Progression
  3. 1383
    “…MicroRNA (miRNA) and fibroblast growth factor receptor 1 (FGFR1) dysregulation are considered to play an important role in tumor proliferation, invasion, and metastasis. …”
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    Reciprocal regulatory mechanism between miR-214-3p and FGFR1 in FGFR1-amplified lung cancer
  4. 1384
    “…GLP1RAs may play a positive role in improving depression by improving satiety and acting on brain centers responsible for anxiety and depression. …”
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    FRI648 GLP-1RA And SGLT2i Treatments May Show Improved Depression Metrics In Diabetes Treatment
  5. 1385
    “…Previously identified N-hexyl trazodone derivatives, 2-(6-(4-(3-chlorophenyl)piperazin-1-yl)hexyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one hydrochloride (7a·HCl), with high affinity for 5-HT(1A)R and 2-(6-(4-([1,1′-biphenyl]-2-yl)piperazin-1-yl)hexyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one hydrochloride (7b·HCl), a dual-acting 5-HT(1A)/5-HT(7) receptor ligand, were prepared with a new microwave-assisted method. …”
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    New, Eco-Friendly Method for Synthesis of 3-Chlorophenyl and 1,1′-Biphenyl Piperazinylhexyl Trazodone Analogues with Dual 5-HT(1A)/5-HT(7) Affinity and Its Antidepressant-like Activity
  6. 1386
    “…In conclusion, this study firstly suggests that MBNL1‐AS1 acts as a tumor suppressor of BC by targeting miR‐135a/PHLPP2/FOXO1 axis, providing a novel insight for BC diagnosis and treatment.…”
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    LncRNA MBNL1‐AS1 represses cell proliferation and enhances cell apoptosis via targeting miR‐135a‐5p/PHLPP2/FOXO1 axis in bladder cancer
  7. 1387
    “…Angiotensin II (Ang II) upregulates transforming growth factor-beta1 (TGF-β1) and endothelin-1 (ET-1) in various types of cells, and all of them act as profibrotic mediators. …”
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    Dual Blockade of TGF-β Receptor and Endothelin Receptor Synergistically Inhibits Angiotensin II-Induced Myofibroblast Differentiation: Role of AT(1)R/G(αq)-Mediated TGF-β1 and ET-1 Signaling
  8. 1388
    “…CRIF1, a multifunctional factor, plays a pivotal role in a series of cell biological progresses such as cell cycle, cell proliferation, and energy metabolism. …”
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    Multifunctions of CRIF1 in cancers and mitochondrial dysfunction
  9. 1389
    “…As research progressed, it was discovered that cytoskeleton protein 4.1 plays a vital role in cancer as a tumor suppressor. …”
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    The Role of Cytoskeleton Protein 4.1 in Immunotherapy
  10. 1390
    “…In addition, HMGB1 has previously been found as an extracellularly acting protein enhancing neurite outgrowth in cultured neurons. …”
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    Regulation of Neurogenesis in Mouse Brain by HMGB1
  11. 1391
    “…CONCLUSION: TET1 acts as a key factor mediating demethylation, the mechanism of which still remains to be investigated in detail. …”
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    Advances in the DNA methylation hydroxylase TET1
  12. 1392
    “…This perturbation of the normal process of tissue homeostasis causes apoptosis, and the animals do not survive. We conclude that Ldb1-mediated transcriptional regulation plays a major role in adult intestinal homeostasis.…”
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    Role of Ldb1 in Adult Intestinal Homeostasis
  13. 1393
    “…Recent studies have shown that the VEGFA co-receptor neuropilin 1 (NRP1) could be playing a fundamental role in steering VEGFA-induced responses of vascular endothelial cells towards angiogenesis or vascular permeability. …”
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    Neuropilin 1 Regulation of Vascular Permeability Signaling
  14. 1394
    “…Here, we compared the expression profiles of wildtype and Fgfrl1 mutant kidneys to identify genes that act downstream of Fgfrl1 signaling during the early steps of nephron formation. …”
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    Comparison of the Gene Expression Profiles from Normal and Fgfrl1 Deficient Mouse Kidneys Reveals Downstream Targets of Fgfrl1 Signaling
  15. 1395
    “…Lastly, additional work on Tax1BP2 will also provide insight into how the cell suppresses centrosome re-duplication during the cell cycle and the role that Tax1BP2 plays in this important cellular pathway.…”
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    HTLV-1 Tax: centrosome amplification and cancer
  16. 1396
    “…Ceramide-1-phosphate (C1P) plays an important role in several biological processes, being identified as a key regulator of many protein functions. …”
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    Influence of calcium on ceramide-1-phosphate monolayers
  17. 1397
    “…In addition to direct protective effects on neurons, several studies revealed anti-inflammatory effects of IGF-1 acting on astrocytes and microglia, and that IGF-1 may also inhibit blood brain barrier permeability. …”
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    Insulin-Like Growth Factor-1 and Neuroinflammation
  18. 1398
    “…The results indicate that the splicing and muscle pathological alterations observed are related to the clinical phenotype both in DM1 and in DM2 and that CUGBP1 seems to play a role in classic DM1 but not in DM2. …”
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    Overexpression of CUGBP1 in Skeletal Muscle from Adult Classic Myotonic Dystrophy Type 1 but Not from Myotonic Dystrophy Type 2
  19. 1399
    “…Moreover, we show that Kv1.1 protein is mislocalized in dolk mutants, suggesting they act in a common genetic pathway. …”
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    A forward genetic screen identifies Dolk as a regulator of startle magnitude through the potassium channel subunit Kv1.1
  20. 1400
    “…In summary, our results provide phylogenetic overview of U1-70K gene family in vertebrates. In silico analyses conducted in this work will act as a reference for future functional studies of this crucial U1 splicing factor in animal kingdom.…”
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    Phylogenetic comparison and splice site conservation of eukaryotic U1 snRNP-specific U1-70K gene family
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