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  1. 1501
    “…Increasing evidences showed that long non-coding RNAs (lncRNAs) play vital roles in tumor progression. Recent studies indicated that lncRNA TUG1 was upregulated and promoted tumor processes in several cancers. …”
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    Long non-coding RNA TUG1 promotes cervical cancer progression by regulating the miR-138-5p-SIRT1 axis
  2. 1502
    “…Our results show how evolutionary changes in cis as well as trans acting signals have played a fundamental role in determining NDE1 species specific splicing isoforms supporting the notion that alternative splicing plays a central role in human genome evolution, and possibly human cognitive predominance.…”
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    Human NDE1 splicing and mammalian brain development
  3. 1503
    por Kumar, A., Saba, JD.
    Publicado 2015
    “…In response to a stimulus, S1P is produced intracellularly by the action of two sphingosine kinases, and then it is exported to the extracellular environment or acts as an intracellular second messenger. …”
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    Regulation of Immune Cell Migration by Sphingosine-1-Phosphate
  4. 1504
    “…KAP1 (KRAB domain–associated protein 1) plays a fundamental role in regulating gene expression in mammalian cells by recruiting different transcription factors and altering the chromatin state. …”
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    KAP1 is an antiparallel dimer with a functional asymmetry
  5. 1505
    “…Previous studies showed that SRCIN1 played a tumor suppressor role in the development of lung cancer and breast cancer. …”
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    SRCIN1 Suppressed Osteosarcoma Cell Proliferation and Invasion
  6. 1506
    “…In this review, we focus on one member of the family, TRIB1, and its role at the crossroads of immune signaling. …”
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    The Pseudokinase TRIB1 in Immune Cells and Associated Disorders
  7. 1507
    “…Here, we showed that two Arabidopsis histone demethylases, LYSINESPECIFIC DEMETHYLASE LIKE 1 and 2 (LDL1 and LDL2) act redundantly in repressing of seed dormancy. …”
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    Arabidopsis histone demethylases LDL1 and LDL2 control primary seed dormancy by regulating DELAY OF GERMINATION 1 and ABA signaling-related genes
  8. 1508
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    HIV-1 Tat alters neuronal intrinsic excitability
  9. 1509
    “…In this study, we demonstrate that the presence of Cav-1 in TDE acts as a potent driver to induce CSC phenotypes and epithelial–mesenchymal transition in PCa undergoing neuroendocrine differentiation through NFκB signaling pathway. …”
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    The paracrine induction of prostate cancer progression by caveolin-1
  10. 1510
    “…A comparison of their target genes reveals that the REV/KAN1 module acts in organ patterning through opposite regulation of shared targets. …”
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    Genome-Wide Identification of KANADI1 Target Genes
  11. 1511
    “…Our estimates suggest that one of the most convincing examples of adaptive introgression is in fact selection acting on standing archaic variation.…”
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    The history and evolution of the Denisovan-EPAS1 haplotype in Tibetans
  12. 1512
    “…In addition, both transgenic and pharmacological studies have shown that serotonin acts on Htr1a during development to modulate anxiety in adulthood, demonstrating a function for this receptor in the maturation of anxiety circuits in the brain. …”
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    Modulation of anxiety by cortical serotonin 1A receptors
  13. 1513
    “…Here, we demonstrate that Sar1 acts as the curvature-sensing component of the COPII coat complex and highlight the ability of Sar1 to bind more avidly to membranes of high curvature. …”
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    Sar1 GTPase Activity Is Regulated by Membrane Curvature
  14. 1514
    “…In renal disease, TPRA1 plays different roles in different cell types accordingly. …”
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    Role of TRPA1 in Tissue Damage and Kidney Disease
  15. 1515
    por Xie, B, Tam, N N C, Tsao, S W, Wong, Y C
    Publicado 1999
    “…The data, therefore, suggest that VEGF may act as an autocrine growth factor for mammary cancer cells in vivo and this autocrine regulatory role may be mediated through flk-1. …”
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    Co-expression of vascular endothelial growth factor (VEGF) and its receptors (flk-1 and flt-1) in hormone-induced mammary cancer in the Noble rat
  16. 1516
    “…The breast cancer 1 (BRCA1) protein is a tumor suppressor playing roles in DNA repair and cell cycle regulation. …”
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    Interaction between DNA Polymerase β and BRCA1
  17. 1517
    “…CONCLUSIONS: The present results support the hypothesis that low copy gene number within REXO1L1 cluster could play a significant role in this complex clinical and cellular phenotype.…”
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    Deletion of REXO1L1 locus in a patient with malabsorption syndrome, growth retardation, and dysmorphic features: a novel recognizable microdeletion syndrome?
  18. 1518
    “…The conserved nickel/copper operon rcnR-rcnA-pcoE-ISSgsp1-pcoS-IS903-mcr-9-wbuC was present, which may play a key role in copper tolerance under anaerobic growth and nickel homeostasis. …”
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    Genomic Analysis of a mcr-9.1-Harbouring IncHI2-ST1 Plasmid from Enterobacter ludwigii Isolated in Fish Farming
  19. 1519
    “…Further study showed that high expression of DYNC1H1 was enriched in epithelial–mesenchymal transition (EMT) and the TGF β signaling pathway by GSEA analysis enrichment, indicating that DYNC1H1 might play a key role in the progression of CRC through EMT and immune response, which also had been validated by the experimental assays. …”
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    A Prognosis Marker Dynein Cytoplasmic 1 Heavy Chain 1 Correlates with EMT and Immune Signature in Liver Hepatocellular Carcinoma by Bioinformatics and Experimental Analysis
  20. 1520
    “…We propose that Lnp1p and Sey1p act antagonistically to balance polygonal network formation. …”
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    ER network formation requires a balance of the dynamin-like GTPase Sey1p and Lnp1p, a member of the Lunapark family
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