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1561por Liu, Jiazhe, Li, Hongchang, Wei, Chuanchao, Ding, Junbin, Lu, Jingfeng, Pan, Gaofeng, Mao, Anwei“…Also, circFAT1(e2) acted as a sponge for potential microRNAs (miRNAs) to modulate cancer progression. …”
Publicado 2020
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1562“…OBJECTIVE: Aberrant expression of ten-eleven translocation 1 (TET1) plays a critical role in tumor development and progression. …”
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1563por Schaschl, Helmut, Huber, Susanne, Schaefer, Katrin, Windhager, Sonja, Wallner, Bernard, Fieder, Martin“…Additionally, in the intron 3 of the OXTR gene, the SNP rs59190448 appears to be under positive directional selection. For rs59190448, only one phenotypical association is known so far, but it is in high LD’ (>0.8) with loci of known association; i.e., variants associated with key pro-social behaviours and mental disorders in humans. …”
Publicado 2015
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1564por Jia, Lang, Zhang, Yun, Pu, Feng, Yang, Chong, Yang, Shula, Yu, Jinze, Xu, Zihan, Yang, Hongji, Zhou, Yu, Zhu, Shikai“…Moreover, we found that AK4 acts as a cognate gene of AK4P1 and also predicts worse survival for PDAC patients. …”
Publicado 2022
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1565por Al-toub, Mashael, Vishnubalaji, Radhakrishnan, Hamam, Rimi, Kassem, Moustapha, Aldahmash, Abdullah, Alajez, Nehad M.“…INTRODUCTION: Tumor microenvironment conferred by stromal (mesenchymal) stem cells (MSCs) plays a key role in tumor development, progression, and response to therapy. …”
Publicado 2015
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1566por Chen, Xiaoxiang, Zeng, Kaixuan, Xu, Mu, Hu, Xiuxiu, Liu, Xiangxiang, Xu, Tao, He, Bangshun, Pan, Yuqin, Sun, Huiling, Wang, Shukui“…Our data demonstrated that SP1-induced ZFAS1 contributed to CRC progression by upregulating VEGFA via competitively binding to miR-150-5p, which acts as a tumor suppressor by targeting VEGFA in CRC.…”
Publicado 2018
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1567por Zhu, Zhonglin, Rong, Zeyin, Luo, Zai, Yu, Zhilong, Zhang, Jing, Qiu, Zhengjun, Huang, Chen“…Mechanistically, circNHSL1 acted as a miR-1306-3p sponge to relieve the repressive effect of miR-1306-3p on its target SIX1. …”
Publicado 2019
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1568por Leong, Clement C., Chapman, Tara L., Bjorkman, Pamela J., Formankova, Danuska, Mocarski, Edward S., Phillips, Joseph H., Lanier, Lewis L.“…CMV causes downregulation of class I major histocompatibility complex (MHC) expression in infected cells; however, it has been proposed that a class I MHC homolog encoded by CMV, UL18, may act as a surrogate ligand to prevent NK cell lysis of CMV-infected cells. …”
Publicado 1998
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1569por Kalocsai, Csilla, Amaral, Andre, Piquette, Dominique, Walter, Grace, Dev, Shelly P., Taylor, Paul, Downar, James, Gotlib Conn, Lesley“…Nineteen family members of critically ill patients who acted as substitute decision-makers and/or regularly interacted with ICU providers were interviewed. …”
Publicado 2018
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1570por Nanao, Max, Ricard-Blum, Sylvie, Di Guilmi, Anne Marie, Lemaire, David, Lascoux, David, Chabert, Jacqueline, Attree, Ina, Dessen, Andréa“…LcrV, the homolog of PcrV in Yersinia, has been proposed to participate in effector secretion regulation by interacting with LcrG, which may act as a secretion blocker. Although PcrV also recognizes PcrG within the bacterial cytoplasm, the roles played by the two proteins in type III secretion in Pseudomonas may be different from the ones suggested for their Yersinia counterparts. …”
Publicado 2003
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1571por Higuchi, Kentaro, Kazeto, Yukinori, Ozaki, Yuichi, Izumida, Daisuke, Hotta, Takuro, Soyano, Kiyoshi, Gen, Koichiro“…Taken together, these findings suggest that IGF-1 and IGF-2 act directly on follicle cells to stimulate steroid production through an increase in gene expression and enzymatic activity of cyp17a1 via induction of PI3 kinase.…”
Publicado 2020
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1572“…However, previous studies have shown that miR-149 can directly target FOXM1 and act as tumor suppressor in CRC. Consequently, our results showed that miR-149 could directly bind to circANKS1B and FOXM1. …”
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1573por Staszewski, Jacek, Lazarewicz, Natalia, Konczak, Julia, Migdal, Iwona, Maciaszczyk-Dziubinska, Ewa“…Up-frameshift protein 1 (UPF1) plays the role of a vital controller for transcripts, ready to react in the event of an incorrect translation mechanism. …”
Publicado 2023
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1574“…Mitochondrial quality control has an impact on many diseases, but intense research has focused on the action of 2 genes linked to heritable forms of Parkinson disease (PD), PINK1 and PARK2/parkin, which act in a common pathway to promote mitophagy. …”
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1575por Kienhöfer, Sabine, Musheev, Michael U., Stapf, Ulrike, Helm, Mark, Schomacher, Lars, Niehrs, Christof, Schäfer, Andrea“…DNA demethylation plays a central role during development and in adult physiology. …”
Publicado 2015
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1576“…HO-1 is a potent antioxidant. It can act as an anti-inflammatory, proliferative, angiogenic and cytoprotective enzyme. …”
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1577por Wang, Wenxi, Zhou, Ruoyu, Wu, Yuwei, Liu, Yicong, Su, Wenjia, Xiong, Wei, Zeng, Zhaoyang“…PVT1 can act as a “sponge” for miRNAs to inhibit their activities, thereby affecting proliferation, invasion, and angiogenesis of cancer. …”
Publicado 2019
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1578por Tong, Yuanhao, Cao, Yinghao, Jin, Tianzhe, Huang, Zhengwei, He, Qinyuan, Mao, Min“…As pivotal members of inflammatory cytokines, Interleukin-1 (IL-1) family plays a crucial role in this process. …”
Publicado 2022
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1579“…ABSTRACT: YY1 is widely recognized as an intrinsically disordered transcription factor that plays a role in development of many cancers. …”
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1580“…Divergent and conserved molecular functions of Wtx/Amer1, Amer2 and Amer3 are discussed.…”
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