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  1. 1701
    “…The second theme, “aligning a pathway to service delivery”, illustrates a reflective balancing act between their personal values and societal norms in service delivery, while the third theme, “health practitioners acting as gatekeepers”, describes how this balancing act oscillates between enabling and blocking behaviours. …”
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    ‘One-size doesn’t fit all’: Understanding healthcare practitioners’ perceptions, attitudes and behaviours towards sexual and reproductive health and rights in low resource settings: An exploratory qualitative study
  2. 1702
    por Li, Di, Ni, Haibo, Rui, Qin, Gao, Rong, Chen, Gang
    Publicado 2018
    “…Despite the fact that the biological function of Mst1 and its role in the cell's signalling network have yet to be determined, however, there is a lot of evidence that Mst1 plays an important role in cell death which results from tissue injury. …”
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    Mst1: Function and Mechanism in Brain and Myocardial Ischemia Reperfusion Injury
  3. 1703
    “…Here we report that the yeast orthologue of fuzzy onions, Fzo1p, plays a direct and conserved role in mitochondrial fusion. …”
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    Mitochondrial Fusion in Yeast Requires the Transmembrane GTPase Fzo1p
  4. 1704
    “…Recent studies suggest that the induction of HO-1 expression plays a critical protective role in intestinal damage models induced by ischemia-reperfusion, indomethacin, lipopolysaccharide-associated sepsis, trinitrobenzene sulfonic acid, and dextran sulfate sodium, indicating that activation of HO-1 may act as an endogenous defensive mechanism to reduce inflammation and tissue injury in the gastrointestinal tract. …”
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    Heme oxygenase-1: a novel therapeutic target for gastrointestinal diseases
  5. 1705
    por Li, Hongxu, Gao, Jie, Zhang, Shuijun
    Publicado 2021
    “…In addition, some long non-coding RNAs (lncRNAs) or miRNAs directly or indirectly act on CADM1 to regulate tumor growth and motility. …”
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    Functional and Clinical Characteristics of Cell Adhesion Molecule CADM1 in Cancer
  6. 1706
    “…Thus histidine residues could play a critical role in the nuclease activity of hPLSCR1. …”
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    Identification and characterization of the novel nuclease activity of human phospholipid scramblase 1
  7. 1707
    por Mim, Carsten, Perkins, Guy, Dahl, Gerhard
    Publicado 2021
    “…Pannexin 1 (Panx1) plays a decisive role in multiple physiological and pathological settings, including oxygen delivery to tissues, mucociliary clearance in airways, sepsis, neuropathic pain, and epilepsy. …”
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    Structure versus function: Are new conformations of pannexin 1 yet to be resolved?
  8. 1708
    por Cho, Young-Hee, Yoo, Sang-Dong
    Publicado 2011
    “…For fructose signaling responses, the plant glucose sensor HEXOKINASE1 (HXK1) was dispensable, while FRUCTOSE INSENSITIVE1 (FINS1), a putative FRUCTOSE-1,6-BISPHOSPHATASE, played a crucial role. …”
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    Signaling Role of Fructose Mediated by FINS1/FBP in Arabidopsis thaliana
  9. 1709
    “…Rab escort protein 1 (REP1), a component of the Rab geranyl-geranyltransferase 2 complex, plays a role in Rab protein recruitment in proper vesicles during vesicle trafficking. …”
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    REP1 Modulates Autophagy and Macropinocytosis to Enhance Cancer Cell Survival
  10. 1710
    por Ray, Patricio E.
    Publicado 2012
    “…Zhong et al. show that the oral administration of a cyclic nucleotide phosphodiesterase 4 inhibitor and a retinoic acid receptor-alpha agonist can prevent the development of HIVAN in transgenic mice, acting through a cAMP dependent mechanism that is independent of HIV-1 genes. …”
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    Can we cure HIV-1 associated nephropathy in transgenic mice?
  11. 1711
    “…The cannabinoid receptor type 1 (CB1) plays critical roles in multiple physiological processes such as pain perception, brain development and body temperature regulation. …”
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    A novel bioassay for quantification of surface Cannabinoid receptor 1 expression
  12. 1712
    por Simpson-Lavy, Kobi, Kupiec, Martin
    Publicado 2023
    “…This inactivates Snf1 and leads to Snf1 degradation. More recently, glucose-induced proton export has been found to result in Snf1 inhibition via a polyhistidine tract (13 consecutive histidine residues) at the N-terminus of the Snf1 protein. …”
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    Glucose Inhibits Yeast AMPK (Snf1) by Three Independent Mechanisms
  13. 1713
    “…These findings therefore provide additional insights into the role played by HTRA1 in regulating mesenchymal stem cell differentiation, and offer opportunities for improving our understanding of how this multifunctional protease may act to influence bone quality.…”
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    Role of HTRA1 in bone formation and regeneration: In vitro and in vivo evaluation
  14. 1714
    “…Furthermore, PGC-1α is an emerging protein with a biphasic role in cancer, acting both as a tumor suppressor and a tumor promoter and thus representing a new and unresolved topic for cancer biology studies. …”
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    PGC-1α as a Pivotal Factor in Lipid and Metabolic Regulation
  15. 1715
    “…We detected evidence of positive selection acting on residues in complexes I and V, and we used homology protein structure modeling to assess the effect of the biochemical properties of the selected residues on the enzyme structure. …”
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    Evidence of Positive Selection in Mitochondrial Complexes I and V of the African Elephant
  16. 1716
    “…We demonstrate that WNK1 is a negative regulator of integrin-mediated adhesion, whereas it acts as a positive regulator of migration via OXSR1 and STK39 kinases and the SLC12A2 ion co-transporter. …”
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    WNK1 kinase balances T cell adhesion versus migration in vivo
  17. 1717
    “…Together, these data indicate that signaling through RAMP1 and CLR plays a role in mediating asthma pathology. …”
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    Deficiency of RAMP1 Attenuates Antigen-Induced Airway Hyperresponsiveness in Mice
  18. 1718
    “…Small GTPase Rap1 plays a prominent role in endothelial cell (EC) homeostasis by promoting NO release. …”
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    Distinct Signaling Functions of Rap1 Isoforms in NO Release From Endothelium
  19. 1719
    “…Variants of HCN1 have been recognized as causes of epilepsy, and mutant HCN1 channels could act with loss-of-function (LOF), loss- and gain-of-function (LOF and GOF) and gain-of-function (GOF) mechanisms. …”
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    Novel HCN1 Mutations Associated With Epilepsy and Impacts on Neuronal Excitability
  20. 1720
    “…Glycoprotein B (gB) plays an important role in alphaherpesvirus cellular entry and acts in concert with gD and the gH/gL complex. …”
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    Comparative Analysis of Glycoprotein B (gB) of Equine Herpesvirus Type 1 and Type 4 (EHV-1 and EHV-4) in Cellular Tropism and Cell-to-Cell Transmission
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