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  1. 1721
    “…OBJECTIVE: The long non‐coding RNA zinc finger E‐box‐binding homeobox 1 antisense 1 (ZEB1‐AS1) acts as an oncogenic regulator in many human tumours. …”
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    Long non‐coding RNA ZEB1‐AS1 promotes colon adenocarcinoma malignant progression via miR‐455‐3p/PAK2 axis
  2. 1722
    “…Copper, the highly toxic micronutrient, plays two essential roles: it is a catalytic and structural cofactor for Cu-dependent enzymes, and it acts as a secondary messenger. …”
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    CRISP-R/Cas9 Mediated Deletion of Copper Transport Genes CTR1 and DMT1 in NSCLC Cell Line H1299. Biological and Pharmacological Consequences
  3. 1723
    “…CONCLUSION: This is the first time to report that miR-335-5p regulates ROCK1 and impairs its functions, thereby playing a key role in TGF-β1-induced EMT and cell migration and invasion in NSCLC.…”
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    miR-335-5p inhibits TGF-β1-induced epithelial–mesenchymal transition in non-small cell lung cancer via ROCK1
  4. 1724
    por Yuan, Zhen, Ye, Mu, Qie, Jingbo, Ye, Tao
    Publicado 2020
    “…BACKGROUND: Forkhead box protein A1 (FOXA1), acting as a transcriptional activator for liver-specific transcripts, plays a vital part in proliferation, apoptosis and cell cycle. …”
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    FOXA1 Promotes Cell Proliferation and Suppresses Apoptosis in HCC by Directly Regulating miR-212-3p/FOXA1/AGR2 Signaling Pathway
  5. 1725
    “…Recent evidence supports sigma-1 receptor modulation in both neuroprotection and antiseizure activity, suggesting that sigma-1 receptors may play a role in the pathogenesis of DEEs, and that targeting this receptor has the potential to positively impact both seizures and non-seizure outcomes in these disorders. …”
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    An Emerging Role for Sigma-1 Receptors in the Treatment of Developmental and Epileptic Encephalopathies
  6. 1726
    “…MicroRNAs are small non-coding RNA molecules which act as modulators of gene function, and have been identified as playing important roles in cancer as both tumor suppressors and oncogenes. …”
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    MicroRNA-198 suppresses prostate tumorigenesis by targeting MIB1
  7. 1727
    “…TTK, could affect the prognosis of HCC with MT1-deletion and non-deletion. NR1I2, CYP8B1, and BUB1 were associated with the prognosis of HCC with MT1-deletion. …”
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    Identification of Potential Biomarkers From Hepatocellular Carcinoma With MT1 Deletion
  8. 1728
    “…BACKGROUND: Circular RNA (circRNA), a subclass of non-coding RNA, plays a critical role in cancer tumorigenesis and metastasis. …”
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    A novel protein AXIN1-295aa encoded by circAXIN1 activates the Wnt/β-catenin signaling pathway to promote gastric cancer progression
  9. 1729
    “…Here, we found that Ef P-III-1 acted not only in fibrinogenolysis, but also in fibrogenesis. …”
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    Eisenia fetida Protease-III-1 Functions in Both Fibrinolysis and Fibrogenesis
  10. 1730
    “…The trans-acting elements binding to the mutation sites could play a role in the methylation spreading.…”
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    Spreading of Alu Methylation to the Promoter of the MLH1 Gene in Gastrointestinal Cancer
  11. 1731
    por Ziegon, Laura, Schlegel, Martin
    Publicado 2021
    “…Over the last 20 years, it has been established that netrin-1 acts as a chemoattractive or chemorepulsive cue in diverse biological processes far beyond neuronal development. …”
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    Netrin-1: A Modulator of Macrophage Driven Acute and Chronic Inflammation
  12. 1732
    “…The family of RecQ helicases is evolutionary conserved from bacteria to humans and play key roles in genome stability. The budding yeast RecQ helicase Sgs1 has been implicated in several key processes during the repair of DNA damage by homologous recombination as part of the STR complex (Sgs1-Top3-Rmi1). …”
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    Smc5/6 complex regulates Sgs1 recombination functions
  13. 1733
    por Biermann, Amy R., Hogan, Deborah A.
    Publicado 2022
    “…C. auris MRR1a alleles were functional in Candida lusitaniae and were inducible by BEN, but not by MG, suggesting that the two Mrr1 inducers act via different mechanisms. …”
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    Transcriptional Response of Candida auris to the Mrr1 Inducers Methylglyoxal and Benomyl
  14. 1734
    “…Given the importance of damage-induced cell death for maintenance of genomic stability, we examined whether Nfkb1 acts as a tumor suppressor in the setting of alkylation damage. …”
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    Nfkb1 is a haploinsufficient DNA damage-specific tumor suppressor
  15. 1735
    “…The sigma-1 receptor (Sig-1R) is a chaperone that resides mainly at the mitochondrion-associated endoplasmic reticulum (ER) membrane (called the MAMs) and acts as a dynamic pluripotent modulator in living systems. …”
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    Roles of sigma-1 receptors on mitochondrial functions relevant to neurodegenerative diseases
  16. 1736
    “…Upon entry of human immunodeficiency virus 1 (HIV-1) into the host, innate immune mechanisms are acting as a first line of defense, that considerably also modify adaptive immunity by the provision of specific signals. …”
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    Role of Complement Receptors (CRs) on DCs in Anti-HIV-1 Immunity
  17. 1737
    “…These proteins are excluded in isolated cilia from fla11-1 (IFT172) and fla24-1 (DHC1b). Our data support the idea that RPGRIP1L, but not IFT proteins, acts as part of the gate for cytoplasmic proteins. …”
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    RPGRIP1L helps to establish the ciliary gate for entry of proteins
  18. 1738
    “…METHODS: Two experiments were performed to test the effects of an NK1 receptor (at which SP primarily acts) antagonist on learning and performing action sequences. …”
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    The NK1 antagonist L-733,060 facilitates sequence learning
  19. 1739
    “…CONCLUSIONS: ZBP1 may indicate that females have a high incidence rate of SLE, and it plays a significant role in the occurrence and progression of SLE.…”
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    ZBP1 is a significant pyroptosis regulator for systemic lupus erythematosus
  20. 1740
    “…Moreover, UBQLN1 promotes ubiquitin, p62, and LC3 accumulation around Mtb, acting independently of the E3 ligase parkin. …”
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    Ubiquilin 1 Promotes IFN-γ-Induced Xenophagy of Mycobacterium tuberculosis
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