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  1. 1801
    “…The GTase domain of bifunctional penicillin-binding proteins (PBPs) of class A, such as Escherichia coli PBP1b, belong to the GTase 51 family. These enzymes play an essential role in PG synthesis, and their specific inhibition by moenomycin was shown to lead to bacterial cell death. …”
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    Squalamine and Aminosterol Mimics Inhibit the Peptidoglycan Glycosyltransferase Activity of PBP1b
  2. 1802
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    ‘I Am Not The Doctor For You’: Physicians’ Attitudes About Caring For People With Disabilities
  3. 1803
    por Xu, Weiming, Liu, Lizhi, Hornby, David
    Publicado 2012
    “…Recent genetic studies have shown that PCSK9, one of the key genes in cholesterol metabolism, plays a critical role by controlling the level of low-density lipoprotein receptor. …”
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    c-IAP1 Binds and Processes PCSK9 Protein: Linking the c-IAP1 in a TNF-α Pathway to PCSK9-Mediated LDLR Degradation Pathway
  4. 1804
    “…As such, the Ins(1,4,5)P(3) receptor plays fundamental roles in cellular physiology. …”
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    Phosphorylation of the rat Ins(1,4,5)P(3) receptor at T930 within the coupling domain decreases its affinity to Ins(1,4,5)P(3)
  5. 1805
    “…Type I interferon (IFN) genes and interferon-stimulated genes (ISG) coding for antiviral-acting proteins, such as MxA, OAS-1 or PKR, are primary targets of these signaling cascades. β- and γ-catenin are closely related armadillo repeat-containing proteins with dual roles. …”
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    β-catenin promotes the type I IFN synthesis and the IFN-dependent signaling response but is suppressed by influenza A virus-induced RIG-I/NF-κB signaling
  6. 1806
    “…In primary cultures of human adrenal cells BMP4 inhibited the ability of ACTH to increase cortisol production (↓75%), as well as CYP11B1(↓65%) and CYP17A1 (↓57%) expression. CONCLUSION: Our findings indicate that the human adrenal has outer cortex localized expression of BMP4 that could play a paracrine/autocrine role in zone-specific production of aldosterone vs. cortisol through BMP4 selective inhibition of CYP17A1 and CYP11B1. …”
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    OR13-5 Bone Morphogenetic Protein-4 (BMP4) Inhibits Adrenal Cell Cortisol Synthesis by Blocking CYP17A1 and CYP11B1 Expression.
  7. 1807
    “…Since NSPc1 acts predominantly as a transcriptional inactivator that specifically represses HOXA11 expression in trophoblast cells during preeclampsia, we further show that NSPc1 is required for DNMT3a recruitment and maintenance of the DNA methylation in the HOXA11 promoter in trophoblast cells during preeclampsia. …”
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    Cooperation between NSPc1 and DNA methylation represses HOXA11 expression and promotes apoptosis of trophoblast cells during preeclampsia: NSPc1 promotes apoptosis during preeclampsia
  8. 1808
    “…Vascular endothelial growth factor (VEGF) produced by granulosa cells and secreted into the follicular fluid plays an essential role in this process. On the other hand, soluble VEGF receptor-1 (sFlt-1) produced by endothelial cells acts as a negative modulator for the bioavailability of VEGF. …”
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    Regulation of soluble vascular endothelial growth factor receptor (sFlt-1/sVEGFR-1) expression and release in endothelial cells by human follicular fluid and granulosa cells
  9. 1809
    “…IL-1β plays critical roles in the priming and effector phases of immune responses such as the differentiation, commitment, and memory formation of T cells. …”
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    Induction of Unique STAT Heterodimers by IL-21 Provokes IL-1RI Expression on CD8(+) T Cells, Resulting in Enhanced IL-1β Dependent Effector Function
  10. 1810
    “…Type I interferons (IFN-I) are a group of related proteins that help regulate the activity of the immune system and play a key role in host defense against viral infections. …”
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    Human Type I Interferon Antiviral Effects in Respiratory and Reemerging Viral Infections
  11. 1811
    “…Mechanistically, HOXA11-AS acted as a molecular sponge for let-7b-5p in the cytoplasm, antagonizing its ability to repress the expression of CTHRC1, which activates the β-catenin/c-Myc pathway. …”
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    LncRNA HOXA11-AS promotes glioma malignant phenotypes and reduces its sensitivity to ROS via Tpl2-MEK1/2-ERK1/2 pathway
  12. 1812
    “…Our work showed that EMX1/EMX2 act as tumor suppressors in sarcomas by repressing the activity of stem cell regulatory genes (OCT4, SOX2, KLF4, MYC, NANOG, NES, and PROM1). …”
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    Regulation of sarcomagenesis by the empty spiracles homeobox genes EMX1 and EMX2
  13. 1813
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    Shall I Trust You? From Child–Robot Interaction to Trusting Relationships
  14. 1814
    “…The adipokines, adiponectin, and intelectin-1 (also known as omentin-1), whose levels are decreased in obesity, act as tumor suppressor factors in various cancers. …”
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    Adiponectin and Intelectin-1: Important Adipokine Players in Obesity-Related Colorectal Carcinogenesis
  15. 1815
    “…Tr1 cells act as key regulators in the immune network, and play a central role in maintaining immune homeostasis. …”
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    Tr1 Cells as a Key Regulator for Maintaining Immune Homeostasis in Transplantation
  16. 1816
    “…The high-mobility group box 1 (HMGB1), a highly conserved nuclear protein that in the extracellular space can act as a damage-associated molecular pattern (DAMP) involved in a large variety of different processes, such as inflammation, migration, invasion, proliferation, differentiation, and tissue regeneration, has recently emerged as a possible regulator of the activity of different immune cell types in the distinct phases of the inflammatory reparative process. …”
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    HMGB1-Mediated Activation of the Inflammatory-Reparative Response Following Myocardial Infarction
  17. 1817
    “…One key feature of age-associated decline is the failure of mechanisms that maintain proper function of the proteome (proteostasis). …”
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    HSF-1: Guardian of the Proteome Through Integration of Longevity Signals to the Proteostatic Network
  18. 1818
    “…Regular exercise is associated with substantial health benefits for individuals with type 1 diabetes (T1D). However, the fear of hypoglycemia (low blood glucose) due to activity-induced declines in blood glucose levels acts as a major barrier to partaking in exercise in this population. …”
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    Type 1 Diabetes and the Menstrual Cycle: Where/How Does Exercise Fit in?
  19. 1819
    “…Our data suggest that Egr1 may act as an important regulator of pain-related synaptic plasticity within the hippocampus.…”
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    Role of Egr1 in Hippocampal Synaptic Enhancement Induced by Tetanic Stimulation and Amputation
  20. 1820
    “…We propose that DEC1 and DEC2 act as an accelerator or a brake in tumor progression. …”
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    DEC1 and DEC2 Crosstalk between Circadian Rhythm and Tumor Progression
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