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  1. 1821
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    Recent Advances on P-Glycoprotein (ABCB1) Transporter Modelling with In Silico Methods
  2. 1822
    por Hrabovszky, Erik, Liposits, Zsolt
    Publicado 2013
    “…Under various physiological and pathological conditions, hormonal and metabolic signals either regulate GnRH neurons directly or act on upstream neuronal circuitries to influence the pattern of pulsatile GnRH secretion into the hypophysial portal circulation. …”
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    Afferent Neuronal Control of Type-I Gonadotropin Releasing Hormone Neurons in the Human
  3. 1823
    “…In this model, by using P2X1−/ − mice, we recently showed that P2X1 receptors, expressed on platelets and neutrophils, play a key role in thrombus growth and fibrin generation. …”
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    Purinergic control of inflammation and thrombosis: Role of P2X1 receptors
  4. 1824
    “…We show that during aging or under dark conditions, accumulation of FHY3 protein decreases, thus lifting its repression on DNA binding of EIN3 and PIF5, leading to the increase of ORE1 expression and onset of leaf senescence. Our combined results suggest that FHY3 and FAR1 act in an age gating mechanism to prevent precocious leaf senescence by integrating light and ethylene signaling with developmental aging.…”
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    Arabidopsis FHY3 and FAR1 Function in Age Gating of Leaf Senescence
  5. 1825
    “…Among angiogenic factors, the cytokines vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), and fibroblast growth factors 1 and 2 (FGF1 and FGF2) play a central role in the initiation of angiogenesis. …”
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    VEGF, FGF1, FGF2 and EGF gene polymorphisms and psoriatic arthritis
  6. 1826
    “…Ectopic expression of PLD1 or PLD2 in human glioma U87 cells increased the expression of hypoxia-inducible factor-1α (HIF-1α) protein. …”
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    Phospholipase D activates HIF-1-VEGF pathway via phosphatidic acid
  7. 1827
    “…CONCLUSION: The strong correlation between ET-1 and its receptors suggests that both play a role in the pathophysiology of rheumatic mitral valve stenosis and may potentially act as biomarkers of this disease.…”
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    Analysis of immunostaining and western blotting of endothelin 1 and its receptors in mitral stenosis
  8. 1828
    “…We found that exposure of HL–1 cardiac cells to Gal–1 reduced the percentage of infection by two different T. cruzi strains, Tulahuén (TcVI) and Brazil (TcI). …”
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    Galectin-1 Prevents Infection and Damage Induced by Trypanosoma cruzi on Cardiac Cells
  9. 1829
    “…Mast cells are powerful immune cells found predominately in barrier tissues. They play an important role in immune surveillance and act as effector cells in allergic reactions. …”
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    Localization-Specific Expression of CCR1 and CCR5 by Mast Cell Progenitors
  10. 1830
    “…Lung cancer is the most frequently diagnosed cancer and the main cause of cancer death in the world. X-box binding protein 1 (XBP1), which is an important transcription factor involved in regulating the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress, might act as a potent oncogenic protein in the processes of tumorigenesis, tumor proliferation and metastasis in various cancers. …”
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    XBP1- IGFBP3 Signaling Pathway Promotes NSCLC Invasion and Metastasis
  11. 1831
    “…CONCLUSIONS: ARMC1 may play a significant role in BRCA and act as a biomarker, which provides valuable clues for the treatment and diagnosis of BRCA.…”
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    The Valuable Role of ARMC1 in Invasive Breast Cancer as a Novel Biomarker
  12. 1832
    “…Mechanistically, circFGFR1 could directly interact with miR-381-3p and subsequently act as a miRNA sponge to upregulate the expression of the miR-381-3p target gene C-X-C motif chemokine receptor 4 (CXCR4), which promoted NSCLC progression and resistance to anti-programmed cell death 1 (PD-1)- based therapy. …”
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    Circular RNA circFGFR1 promotes progression and anti-PD-1 resistance by sponging miR-381-3p in non-small cell lung cancer cells
  13. 1833
    “…c‐MYC and the SWI/SNF chromatin remodeling complex act as master regulators of transcription, and play a key role in human cancer. …”
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    The structure of INI1/hSNF5 RPT1 and its interactions with the c‐MYC:MAX heterodimer provide insights into the interplay between MYC and the SWI/SNF chromatin remodeling complex
  14. 1834
    por Wang, Zhaozhi, Jin, Jianjun
    Publicado 2019
    “…Mechanistically, SLCO4A1-AS1 acted as a sponge of miR-508-3p, leading to upregulation of PARD3 and promotion of CRC cell proliferation. …”
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    LncRNA SLCO4A1-AS1 promotes colorectal cancer cell proliferation by enhancing autophagy via miR-508-3p/PARD3 axis
  15. 1835
    “…In the present study, we focused on the inhibitory action of ETYA on the expression of the chemokine, CCL2/MCP-1, which plays a key role in the initiation and progression of inflammation. …”
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    5, 8, 11, 14-eicosatetraynoic acid suppresses CCL2/MCP-1 expression in IFN-γ-stimulated astrocytes by increasing MAPK phosphatase-1 mRNA stability
  16. 1836
    “…OBJECTIVE: The aim of the present study was to weigh up, at the community level, the respective roles played by pandemic Influenza (pH1N1) virus and co-circulating human Non-Influenza Respiratory Viruses (NIRVs) during the first wave of the 2009 pH1N1 pandemic. …”
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    Intense Co-Circulation of Non-Influenza Respiratory Viruses during the First Wave of Pandemic Influenza pH1N1/2009: A Cohort Study in Reunion Island
  17. 1837
    “…Like many other RNA binding proteins, MBNL proteins can act as both activators or repressors of different splicing events. …”
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    Dissecting domains necessary for activation and repression of splicing by muscleblind-like protein 1
  18. 1838
    por Moreno, Rosa L, Ribera, Angeles B
    Publicado 2014
    “…Little is known, however, about the role that Islet1 might play for development of electrical membrane properties in vertebrates. …”
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    Spinal neurons require Islet1 for subtype-specific differentiation of electrical excitability
  19. 1839
    por Wu, B., Wu, B. F., Feng, Y. J., Tao, J., Ji, Y. H.
    Publicado 2016
    “…The potassium channel Kv 1.3 plays a vital part in the activation of T lymphocytes and is an attractive pharmacological target for autoimmune diseases. …”
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    Mapping the Interaction Anatomy of BmP02 on Kv1.3 Channel
  20. 1840
    “…In conclusion, mGluR5 and CB(1) act in concert to activate neuroprotective cell signaling pathways and promote neuronal survival. …”
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    Orchestrated activation of mGluR5 and CB(1) promotes neuroprotection
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