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  1. 1841
    “…CONCLUSIONS: Our results demonstrate that GPER1 activation promotes the polarization of human neutrophils towards a proinflammatory phenotype and point to GPER1 as a potential therapeutic target in immune diseases where neutrophils play a key role.…”
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    G Protein-Coupled Estrogen Receptor 1 Regulates Human Neutrophil Functions
  2. 1842
    “…Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system (CNS) that is characterized by inflammation which typically results in significant impairment in most patients. Immune checkpoints act as co-stimulatory and co-inhibitory molecules and play a fundamental role in keeping the equilibrium of the immune system. …”
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    Regulation of CTLA-4 and PD-L1 Expression in Relapsing-Remitting Multiple Sclerosis Patients after Treatment with Fingolimod, IFNβ-1α, Glatiramer Acetate, and Dimethyl Fumarate Drugs
  3. 1843
    “…Based on a computational analysis of a microarray dataset related to AD, the H2-Ob gene was previously identified as a potential modulator of the homeostatic balance between mast cells and microglia. Specifically, it plays such a role in the presence of a three-way gene interaction in which the H2-Ob gene acts as a switch in the co-expression relationship of two genes, Csf1r and Milr1. …”
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    RT-DOb, a switch gene for the gene pair {Csf1r, Milr1}, can influence the onset of Alzheimer’s disease by regulating communication between mast cell and microglia
  4. 1844
    “…IMPORTANCE Sphingoid base phosphates, such as sphingosine-1-phosphate (S1P) and dihydrosphingosine-1-phosphate (dhS1P), act as ligands for S1P receptors, and this interaction is known to play a central role in mediating angiogenesis, vascular stability and permeability, and immune cell migration to sites of inflammation. …”
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    Characterization of a Bacterial Kinase That Phosphorylates Dihydrosphingosine to Form dhS1P
  5. 1845
    “…The aim of the present study was to investigate the role of lncRNA GAS5 and its downstream target Nuclear Receptor Subfamily 3 Group C Member 1(NR3C1) in the pathogenesis of multiple sclerosis (MS), and to define the role of GAS5 in the regulation of NR3C1 expression. …”
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    The Growth Arrest-Specific Transcript 5 (GAS5) and Nuclear Receptor Subfamily 3 Group C Member 1 (NR3C1): Novel Markers Involved in Multiple Sclerosis
  6. 1846
    “…The method identified 36 proteins as candidates for authentic Cyr1-interacting partners, together with two known Cyr1-binding proteins, Cap1 and Act1. …”
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    Comprehensive Interactome Analysis for the Sole Adenylyl Cyclase Cyr1 of Candida albicans
  7. 1847
    “…Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. …”
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    The geometry of DNA supercoils modulates the DNA cleavage activity of human topoisomerase I
  8. 1848
    “…Moreover, circMTO1 acted as a ceRNA of miR-182-5p to enhance RASA1 expression. …”
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    CircMTO1 inhibits ox-LDL-stimulated vascular smooth muscle cell proliferation and migration via regulating the miR-182-5p/RASA1 axis
  9. 1849
    “…SIMPLE SUMMARY: The retinoblastoma-like (RBL)1/p107 protein is a member of the retinoblastoma (RB) family including the retinoblastoma (RB)1/p105 protein and RBL2/p130. …”
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    RBL1/p107 Expression Levels Are Modulated by Multiple Signaling Pathways
  10. 1850
    “…In human gastric cancer, TFF1 has been found to decrease, and it has been proposed that it might act as a tumor suppressor factor. …”
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    Immunoexpression of Trefoil Factor 1 in Non-Neoplastic and Neoplastic Canine Gastric Tissues
  11. 1851
    por Naghavi, Mojgan H.
    Publicado 2021
    “…Moreover, interaction of EB1 and +TIPs with actin-MT cross-linking factors coordinate changes in actin and MT dynamics at the cell periphery, as well as during the transition of cargos from one network to the other. …”
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    HIV-1 capsid exploitation of the host microtubule cytoskeleton during early infection
  12. 1852
    “…We have shown that competition between pnictogen bonding and other interactions plays an important role in determining the tilting of the MX(6) (X = a halogen) octahedra of metal halide perovskites in one, two and three-dimensions. …”
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    The Pnictogen Bond, Together with Other Non-Covalent Interactions, in the Rational Design of One-, Two- and Three-Dimensional Organic-Inorganic Hybrid Metal Halide Perovskite Semiconducting Materials, and Beyond
  13. 1853
    “…Long non-coding RNAs, including TMPO-AS1, play a crucial role in PCa progression. However, TMPO-AS1’s function in PCa bone metastasis (BM) and its underlying molecular mechanisms are unclear. …”
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    The long transcript of lncRNA TMPO-AS1 promotes bone metastases of prostate cancer by regulating the CSNK2A1/DDX3X complex in Wnt/β-catenin signaling
  14. 1854
    por Yan, Jiawei, Xu, Hongyan
    Publicado 2021
    “…Thus, these findings highlight that circANKS1B might act as an oncogenic gene to facilitate the metastatic potential and cisplatin resistance in OSCC by sponging miR-515-5p to regulate TGF-β1. …”
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    Regulation of transforming growth factor-beta1 by circANKS1B/miR-515-5p affects the metastatic potential and cisplatin resistance in oral squamous cell carcinoma
  15. 1855
    “…We present the case of two brothers with early osteoporosis who were found to have a heterozygous variant of unknown significance in the WNT1 gene, c.1060_1061delCAinsG (p.H354Afs*39). This finding demonstrates that frameshift variants in WNT1 may also act in a dominant fashion leading to decreased bone mass.…”
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    Heterozygous variant in WNT1 gene in two brothers with early onset osteoporosis
  16. 1856
    “…These findings indicate that IL‐1 and IFN‐γ are each able to act an angiogenesis inhibitor in a situation where FGF plays a major role in angiogenesis, and the activity is synergistically enhanced when they are used in combination.…”
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    Interaction of Interleukin‐1 and Interferon‐γ on Fibroblast Growth Factor‐induced Angiogenesis
  17. 1857
    “…Our results show that, among several cytokines, IFNγ stimulates C/EBPβ expression, which acts as a negative regulator of TFF1 by binding its promoter at three different sites.…”
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    IFNγ-dependent silencing of TFF1 during Helicobacter pylori infection
  18. 1858
    “…Timely and complete replication of the genome is essential for life. The PCNA ring plays an essential role in DNA replication and repair by contributing to the processivity of DNA polymerases and by recruiting proteins that act in DNA replication-associated processes. …”
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    Effects of Defective Unloading and Recycling of PCNA Revealed by the Analysis of ELG1 Mutants
  19. 1859
    “…Some PRRs located on the surface of dendritic cells (DCs) and other cells seem to play an important role in human immunodeficiency virus type 1 (HIV-1) transmission. …”
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    Role of DC-SIGN and L-SIGN receptors in HIV-1 vertical transmission
  20. 1860
    “…Our findings highlight a novel concept in regulation of the melanocortin system and the role played by trafficking receptors SORCS1 and SORCS3 in this process.…”
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    SORCS1 and SORCS3 control energy balance and orexigenic peptide production
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