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  1. 1921
    “…Our findings suggest that phosphorylated nIGF-1R, rather than total nIGF-1R, plays a superior role in these contexts. …”
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    Nuclearly translocated insulin-like growth factor 1 receptor phosphorylates histone H3 at tyrosine 41 and induces SNAI2 expression via Brg1 chromatin remodeling protein
  2. 1922
    “…BACKGROUND: WD40 domains have been found in a plethora of eukaryotic proteins, acting as scaffolding molecules assisting proper activity of other proteins, and are involved in multi-cellular processes. …”
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    GIGANTUS1 (GTS1), a member of Transducin/WD40 protein superfamily, controls seed germination, growth and biomass accumulation through ribosome-biogenesis protein interactions in Arabidopsis thaliana
  3. 1923
    “…Long afterglow phosphors play a significant role in practical applications. …”
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    Study of a color-tunable long afterglow phosphor Gd(1.5)Y(1.5)Ga(3)Al(2)O(12):Tb(3+): luminescence properties and mechanism
  4. 1924
    “…Pathogenesis-related 1 (PR-1) proteins, which are defense proteins in plant–pathogen interactions, play an important role in the resistance and defense of plants against diseases. …”
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    Genome-Wide Characterization and Expression Analysis of Pathogenesis-Related 1 (PR-1) Gene Family in Tea Plant (Camellia sinensis (L.) O. Kuntze) in Response to Blister-Blight Disease Stress
  5. 1925
    “…Furthermore, the rPf_IL-17A/F1, 2 and 3 proteins might activate the NF-κB and MAPK signal pathways by IL-17RA, ACT1, TRAF6, TRAF2, TRAF5 and TAK1, indicating that the three Pf_IL-17A/F proteins may play different roles in promoting inflammatory response.…”
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    Expression and Function Analysis of Interleukin-17A/F1, 2, and 3 Genes in Yellow Catfish (Pelteobagrus fulvidraco): Distinct Bioactivity of Recombinant IL-17A/F1, 2, and 3
  6. 1926
    “…RESULTS: The results indicated that amino acid substitution at residue 144 significantly affected neutralization activity, acting as an escape mutation. CONCLUSIONS: Our data suggest that the newly acquired NGSs in the HA globular head may play an important role in the re-emergence of endemic seasonal H3N2 strain by aiding the escape from humoral immunity.…”
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    Re-emergence of H3N2 strains carrying potential neutralizing mutations at the N-linked glycosylation site at the hemagglutinin head, post the 2009 H1N1 pandemic
  7. 1927
    “…Long noncoding RNA small molecule RNA host gene 1 (SNHG1) has been reported to play critical roles in Parkinson’s disease (PD) progression. …”
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    Long Noncoding RNA SNHG1 Knockdown Ameliorates Apoptosis, Oxidative Stress and Inflammation in Models of Parkinson’s Disease by Inhibiting the miR-125b-5p/MAPK1 Axis
  8. 1928
    por Hardwick, Laura J.A., Philpott, Anna
    Publicado 2019
    “…The processes of cell proliferation and differentiation are intimately linked during embryogenesis, and the superfamily of (basic) Helix-Loop-Helix (bHLH) transcription factors play critical roles in these events. For example, neuronal differentiation is promoted by class II bHLH proneural proteins such as Ngn2 and Ascl1, while class VI Hes proteins act to restrain differentiation and promote progenitor maintenance. …”
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    N-terminal phosphorylation of xHes1 controls inhibition of primary neurogenesis in Xenopus
  9. 1929
    “…METHODS: Here we evaluated the interaction of PGC-1α with the protein A20, which plays a dual-role in the control of the ubiquitin/proteasome system acting as a deubiquitinase and as an E3 ligase. …”
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    A20 deubiquitinase controls PGC-1α expression in the adipose tissue
  10. 1930
    “…Accumulating evidence indicates that the tuberous sclerosis complex 1 (TSC1), a tumor suppressor that acts by inhibiting mTOR signaling, plays an important role in the immune system. …”
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    TSC1 Promotes B Cell Maturation but Is Dispensable for Germinal Center Formation
  11. 1931
    “…GLIS1-3 regulate gene transcription by binding to GLIS binding sites in target genes, whereas circGLIS RNAs largely act as miRNA sponges. …”
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    GLIS1-3: Links to Primary Cilium, Reprogramming, Stem Cell Renewal, and Disease
  12. 1932
    por Deregowska, Anna, Wnuk, Maciej
    Publicado 2021
    “…SIMPLE SUMMARY: RAP1 (TERF2IP) is a member of the shelterin complex that protects telomeric DNA and plays a critical role in maintaining chromosome stability. …”
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    RAP1/TERF2IP—A Multifunctional Player in Cancer Development
  13. 1933
    “…The results of electrophoretic mobility shift assay (EMSA) and yeast one-hybrid experiments showed that AaERF1 was able to bind to the GCC box cis-acting element in vitro and in yeast. …”
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    AaERF1 Positively Regulates the Resistance to Botrytis cinerea in Artemisia annua
  14. 1934
    por Weggel, Loni A., Pandya, Anshul A.
    Publicado 2019
    “…The α4β2 subtype of neuronal nicotinic acetylcholine receptor plays an important role in modulating the signaling pathways for pain. …”
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    Acute Administration of Desformylflustrabromine Relieves Chemically Induced Pain in CD-1 Mice
  15. 1935
    “…Expression array analysis revealed that the transcription of multiple genes was affected and was mostly downregulated in histone H1-deficient cells. This report describes the first histone H1 complete knockout cells in vertebrates and suggests that linker histone H1, while not required for mitotic chromatin condensation, plays important roles in nucleosome spacing and interphase chromatin compaction and acts as a global transcription regulator.…”
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    Histone H1 null vertebrate cells exhibit altered nucleosome architecture
  16. 1936
    “…NADH:ubiquinone oxidoreductase, respiratory complex I, plays a central role in cellular energy metabolism. …”
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    Structural Basis for Inhibition of ROS‐Producing Respiratory Complex I by NADH‐OH
  17. 1937
    “…Given that ZNF750 is emerging as a crucial transcription factor that acts as tumour suppressor gene, here, we show that ZNF750 represses the expression of the small GTPase, Ras-related C3 botulinum toxin substrate 1 (RAC1) in breast cancer cell lines, by directly binding its promoter region. …”
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    The ZNF750–RAC1 axis as potential prognostic factor for breast cancer
  18. 1938
    “…Transcription factor Prospero homeobox 1 (PROX1) is continuously expressed in the lymphatic endothelial cells, playing an essential role in their differentiation. …”
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    The Impact of Transcription Factor Prospero Homeobox 1 on the Regulation of Thyroid Cancer Malignancy
  19. 1939
    “…The RAC1 hyperactivation/copy-number gain is one of the frequently observed features in various solid tumors. …”
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    Active RAC1 Promotes Tumorigenic Phenotypes and Therapy Resistance in Solid Tumors
  20. 1940
    “…BLOS1 interacts with kinesin-3 motor KIF13A, and BLOS1 acts as a new adaptor for kinesin-2 motor KIF3 to coordinate kinesin-3 and kinesin-2 during the long-range transport of recycling endosomes (REs) to plasma membrane along microtubule tracks to overcome hurdles at microtubule intersections. …”
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    BLOS1 mediates kinesin switch during endosomal recycling of LDL receptor
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