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  1. 1941
    “…HIV-1Tat (trans-acting activator of transcription) plays essential roles in the replication through viral mRNA and genome transcription from the HIV-1 LTR promoter. …”
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    Molecular characterization of full-length Tat in HIV-1 subtypes B and C
  2. 1942
    “…MALT1 plays an important role in innate and adaptive immune signaling by acting as a scaffold protein that mediates NF-κB signaling. …”
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    MALT1-Deficient Mice Develop Atopic-Like Dermatitis Upon Aging
  3. 1943
    “…While in hepatocellular carcinoma and acute myeloid leukemia, RIG-I acts as a tumor suppressor through either augmenting STAT1 activation by competitively binding STAT1 against its negative regulator SHP1 or inhibiting AKT-mTOR signaling pathway by directly interacting with Src respectively. …”
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    RIG-I: a multifunctional protein beyond a pattern recognition receptor
  4. 1944
    “…AT1 angiotensin receptor plays important physiological and pathophysiological roles in the cardiovascular system. …”
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    The Role of β-Arrestin Proteins in Organization of Signaling and Regulation of the AT1 Angiotensin Receptor
  5. 1945
    “…Using cell synchronization studies, we confirmed that TRPS1 plays an important role in the control of cells in these phases of the cell cycle. …”
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    A central role for TRPS1 in the control of cell cycle and cancer development
  6. 1946
    “…In this economic game, one player (proposer) plays the first move and proposes how to allocate a given amount of money in an anonymous one-shot interaction. …”
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    Shall I Show My Emotions? The Effects of Facial Expressions in the Ultimatum Game
  7. 1947
    “…Moreover, results show that Pex11pβ interacts with Mff in a DLP1-dependent manner. In conclusion, Mff contributes to the peroxisomal targeting of DLP1 and plays a key role in the fission of the peroxisomal membrane by acting in concert with Pex11pβ and DLP1.…”
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    Mff functions with Pex11pβ and DLP1 in peroxisomal fission
  8. 1948
    “…MDM2 is oncogenic and is frequently found to be over-expressed in human tumors, suggesting its dysregulation plays an important role in human cancers. We have recently found that the Ras effector and RASSF (Ras Association Domain Family) family member RASSF5/NORE1A enhances the levels of nuclear p53. …”
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    NORE1A Regulates MDM2 Via β-TrCP
  9. 1949
    “…Translesion synthesis (TLS) polymerases mediate DNA damage bypass during replication. The TLS polymerase Rev1 has two important functions in the TLS pathway, including dCMP transferase activity and acting as a scaffolding protein for other TLS polymerases at the C‐terminus. …”
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    Involvement of Rev1 in alkylating agent‐induced loss of heterozygosity in Oryzias latipes
  10. 1950
    “…The bioactive lysophospholipid sphingosine-1-phosphate (S1P) acts via five different subtypes of S1P receptors (S1PRs) - S1P(1-5). …”
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    Structural basis for receptor selectivity and inverse agonism in S1P(5) receptors
  11. 1951
    “…Trefoil factor 1 (TFF1) is a small secreted protein expressed in the gastrointestinal tract where, together with the other two members of its family, it plays an essential role in mucosal protection and repair against injury. …”
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    TFF1 Promotes EMT-Like Changes through an Auto-Induction Mechanism
  12. 1952
    “…PKG1α activation by cGMP plays a role in reward and addiction through its actions in the ventral tegmental area (VTA) of the brain. …”
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    PKG1α oxidation negatively regulates food seeking behaviour and reward
  13. 1953
    “…We show here that plectin 1c (P1c), one of the multiple isoforms of the IF-associated cytolinker protein plectin, acts as an MT destabilizer. …”
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    Intermediate filament-associated cytolinker plectin 1c destabilizes microtubules in keratinocytes
  14. 1954
    “…GR suppressed the expression of insulin receptor substrate 1 (IRS-1) by acting as an IRS-1 transcriptional repressor. …”
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    Glucocorticoid receptor–IRS-1 axis controls EMT and the metastasis of breast cancers
  15. 1955
    “…Data from our in vitro experiments show that Sirt6 acted as a transcriptional cofactor of GATA‐1, independent of its catalytic function as a deacetylase or ADP‐ribosyltransferase. …”
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    Sirtuin 6 promotes eosinophil differentiation by activating GATA‐1 transcription factor
  16. 1956
    “…Background: ZEB1 plays a role in epithelial-to-mesenchymal transition and acts as a repressor of E-cadherin, TGF-β, and Wnt/β-catenin. …”
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    Detection of zeb1 Gene in Granulosa Cells in Women Undergoing IVF Treatment
  17. 1957
    “…BRCA1 acts as a hub protein that coordinates a diverse range of cellular pathways to maintain genomic stability. …”
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    The ubiquitin E3 ligase activity of BRCA1 and its biological functions
  18. 1958
    “…The neuropeptide substance-P (SP) is expressed from the TAC1 gene in sensory neurones where it acts as a key modulator of neurogenic inflammation. …”
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    Evidence for regulatory diversity and auto-regulation at the TAC1 locus in sensory neurones
  19. 1959
    “…The protein kinase AKT acts as a node, playing a critical role in controlling cell survival and cell cycle progression. …”
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    AKT Signaling Mediates IGF-I Survival Actions on Otic Neural Progenitors
  20. 1960
    “…BACKGROUND: Corticotropin-releasing hormone (CRH) acts mainly via the CRH receptor 1 (CRH-R1) and plays a crucial role in the stress-induced pathophysiology of irritable bowel syndrome (IBS). …”
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    Corticotropin-Releasing Hormone Receptor 1 Gene Variants in Irritable Bowel Syndrome
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