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  1. 1961
    “…Phosphatase and tensin homolog deleted on chromosome 10 (PTEN)-induced putative kinase 1 (PINK1), a serine/threonine kinase, plays an important role in the quality control of mitochondria and more than 70 PINK1 mutations have been identified to cause early-onset PD. …”
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    Upregulation of human PINK1 gene expression by NFκB signalling
  2. 1962
    “…CONCLUSIONS: Our results demonstrate that Prom1 plays a key role in the regulation of autophagy via upstream suppression of mTOR signaling and also acting as a component of a macromolecular scaffold involving p62 and HDAC6.…”
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    Prominin-1 Is a Novel Regulator of Autophagy in the Human Retinal Pigment Epithelium
  3. 1963
    “…Mechanistically, Stc1 acts by inhibiting Papp-aa, a zinc metalloproteinase degrading Igfbp5a. …”
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    Calcium State-Dependent Regulation of Epithelial Cell Quiescence by Stanniocalcin 1a
  4. 1964
    “…Importantly, apoM is a carrier of the bioactive lipid S1P. S1P acts by binding to five different receptors. …”
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    The apoM/S1P Complex—A Mediator in Kidney Biology and Disease?
  5. 1965
    “…INTRODUCTION: Microsomal prostaglandin E2 synthase-1 (mPGES-1) is an inducible enzyme that acts downstream of cyclooxygenase (COX) to specifically catalyze the conversion of prostaglandin (PG) H(2 )to PGE(2). mPGES-1 plays a key role in inflammation, pain and arthritis; however, the role of mPGES-1 in fibrogenesis is largely unknown. …”
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    mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis
  6. 1966
    “…CONCLUSION: Our study provides strong evidence that NPTX1 plays a crucial role in promoting metastasis and acts as a prognostic indicator in GC.…”
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    NPTX1 promotes metastasis via integrin/FAK signaling in gastric cancer
  7. 1967
    “…Activation of c-Src kinase by a positive feedback mechanism phosphorylates VEGFR-2 at multi-docking site, Y1173. c-Src also catalyzes tyrosine phosphorylation of IQGAP1 and acts as an adaptor to bridge IQGAP1 to VEGFR-2. …”
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    IQGAP1-Dependent Signaling Pathway Regulates Endothelial Cell Proliferation and Angiogenesis
  8. 1968
    “…BACKGROUND: Lymphoid Enhancer Factor-1 (Lef-1) is a member of a transcription factor family that acts as downstream mediator of the Wnt/β-catenin signalling pathway which plays a critical role in osteoblast proliferation and differentiation. …”
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    SLUG: a new target of lymphoid enhancer factor-1 in human osteoblasts
  9. 1969
    “…We show that unlike the PGE(2) receptors EP2 and EP4, the EP1 receptor is a negative regulator that acts at multiple stages of the fracture healing process. …”
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    EP1(−/−) Mice Have Enhanced Osteoblast Differentiation and Accelerated Fracture Repair
  10. 1970
    “…Intracellular chloride channel 1 (CLIC1), a novel metamorphic protein, acts as a sensor of cell oxidation and is involved in inflammation. …”
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    CLIC1 Inhibition Attenuates Vascular Inflammation, Oxidative Stress, and Endothelial Injury
  11. 1971
    “…Here, we propose a new mathematical model of the Notch and Wnt pathways, in which the Hes1 promoter acts as a hub for pathway crosstalk. …”
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    The role of the Hes1 crosstalk hub in Notch-Wnt interactions of the intestinal crypt
  12. 1972
    “…BACKGROUND: Adenosine to inosine (A-to-I) RNA editing has been shown to be an essential event that plays a significant role in neuronal function, as well as innate immunity, in mammals. …”
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    Editing inducer elements increases A-to-I editing efficiency in the mammalian transcriptome
  13. 1973
    por Dhar, Poshmaal, McAuley, Julie
    Publicado 2019
    “…MUC1 is one of the most extensively studied of the cs-mucin family. …”
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    The Role of the Cell Surface Mucin MUC1 as a Barrier to Infection and Regulator of Inflammation
  14. 1974
    “…The secreted signaling molecule Sonic hedgehog (Shh) plays a key role in this process, and the Shh coreceptor growth arrest-specific 1 (Gas1) is expressed in odontogenic mesenchyme and epithelium during multiple stages of tooth development. …”
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    Gas1 Regulates Patterning of the Murine and Human Dentitions through Sonic Hedgehog
  15. 1975
    “…We found, SENP1 possibly plays a critical role in immune infiltration and acts as an expression marker in PAAD, ESCA, and THYM. …”
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    Evidence of Omics, Immune Infiltration, and Pharmacogenomic for SENP1 in the Pan-Cancer Cohort
  16. 1976
    “…Under hypoxic conditions, hypoxia-inducible factor-1 (HIF-1), consisting of HIF-1α and HIF-1β subunits, acts as a key transcription factor mediating the adaptive cellular responses. …”
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    HIF-1α and Caspase-3 expression in aggressive papillary thyroid carcinoma
  17. 1977
    “…Herein we uncovered a novel pathway for the activation of an effective anti-GBM immune response mediated by high-mobility-group box 1 (HMGB1), an alarmin protein released from dying tumor cells, which acts as an endogenous ligand for Toll-like receptor 2 (TLR2) signaling on bone marrow-derived GBM-infiltrating DCs. …”
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    HMGB1 Mediates Endogenous TLR2 Activation and Brain Tumor Regression
  18. 1978
    “…Our findings indicate that BRD1 acts as a regulatory hub in a comprehensive schizophrenia risk network which plays a role in many brain regions throughout life, implicating e.g. striatum, hippocampus, and amygdala at mid-fetal stages. …”
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    Identification of the BRD1 interaction network and its impact on mental disorder risk
  19. 1979
    “…This study aimed to explore whether NGR1 plays a protective role against HF by ameliorating cardiac lipotoxicity via the AMPK pathway. …”
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    Notoginsenoside R1 Ameliorates Cardiac Lipotoxicity Through AMPK Signaling Pathway
  20. 1980
    “…BACKGROUND: Interruption of mature axons activates a cascade of events in neuronal cell bodies which leads to various outcomes from functional regeneration in the PNS to the failure of any significant regeneration in the CNS. One factor which seems to play an important role in the molecular programs after axotomy is the stearoyl Coenzyme A-desaturase-1 (SCD-1). …”
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    Regulation of stearoyl-CoA desaturase-1 after central and peripheral nerve lesions
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