Lung Expression of Human Angiotensin-Converting Enzyme 2 Sensitizes the Mouse to SARS-CoV-2 Infection

por Han, Kun, Blair, Robert V., Iwanaga, Naoki, Liu, Fengming, Russell-Lodrigue, Kasi E., Qin, Zhongnan, Midkiff, Cecily C., Golden, Nadia A., Doyle-Meyers, Lara A., Kabir, Mohammad E., Chandler, Kristin E., Cutrera, Kellie L., Ren, Mi, Monjure, Christopher J., Lehmicke, Gabrielle, Fischer, Tracy, Beddingfield, Brandon, Wanek, Alanna G., Birnbaum, Angela, Maness, Nicholas J., Roy, Chad J., Datta, Prasun K., Rappaport, Jay, Kolls, Jay K., Qin, Xuebin
Publicado 2021

Red blood cell mannoses as phagocytic ligands mediating both sickle cell anaemia and malaria resistance

por Cao, Huan, Antonopoulos, Aristotelis, Henderson, Sadie, Wassall, Heather, Brewin, John, Masson, Alanna, Shepherd, Jenna, Konieczny, Gabriela, Patel, Bhinal, Williams, Maria-Louise, Davie, Adam, Forrester, Megan A., Hall, Lindsay, Minter, Beverley, Tampakis, Dimitris, Moss, Michael, Lennon, Charlotte, Pickford, Wendy, Erwig, Lars, Robertson, Beverley, Dell, Anne, Brown, Gordon D., Wilson, Heather M., Rees, David C., Haslam, Stuart M., Alexandra Rowe, J., Barker, Robert N., Vickers, Mark A.
Publicado 2021

Leveraging a health information exchange for analyses of COVID-19 outcomes including an example application using smoking history and mortality

por Tortolero, Guillermo A., Brown, Michael R., Sharma, Shreela V., de Oliveira Otto, Marcia C., Yamal, Jose-Miguel, Aguilar, David, Gunther, Matt D., Mofleh, Dania I., Harris, Rachel D., John, Jemima C., de Vries, Paul S., Ramphul, Ryan, Serbo, Dritana Marko, Kiger, Jennifer, Banerjee, Deborah, Bonvino, Nick, Merchant, Angela, Clifford, Warren, Mikhail, Jenny, Xu, Hua, Murphy, Robert E., Wei, Qiang, Vahidy, Farhaan S., Morrison, Alanna C., Boerwinkle, Eric
Publicado 2021

Angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and COVID-19-related outcomes: A patient-level analysis of the PCORnet blood pressure control lab

por Smith, Steven M., Desai, Raj A., Walsh, Marta G., Nilles, Ester Kim, Shaw, Katie, Smith, Myra, Chamberlain, Alanna M., Derington, Catherine G., Bress, Adam P., Chuang, Cynthia H., Ford, Daniel E., Taylor, Bradley W., Chandaka, Sravani, Patel, Lav Parshottambhai, McClay, James, Priest, Elisa, Fuloria, Jyotsna, Doshi, Kruti, Ahmad, Faraz S., Viera, Anthony J., Faulkner, Madelaine, O'Brien, Emily C., Pletcher, Mark J., Cooper-DeHoff, Rhonda M.
Publicado 2022

Topologically associating domain boundaries are required for normal genome function

por Rajderkar, Sudha, Barozzi, Iros, Zhu, Yiwen, Hu, Rong, Zhang, Yanxiao, Li, Bin, Alcaina Caro, Ana, Fukuda-Yuzawa, Yoko, Kelman, Guy, Akeza, Adyam, Blow, Matthew J., Pham, Quan, Harrington, Anne N., Godoy, Janeth, Meky, Eman M., von Maydell, Kianna, Hunter, Riana D., Akiyama, Jennifer A., Novak, Catherine S., Plajzer-Frick, Ingrid, Afzal, Veena, Tran, Stella, Lopez-Rios, Javier, Talkowski, Michael E., Lloyd, K. C. Kent, Ren, Bing, Dickel, Diane E., Visel, Axel, Pennacchio, Len A.
Publicado 2023

Exploiting the Autozygome to Support Previously Published Mendelian Gene-Disease Associations: An Update

por Maddirevula, Sateesh, Shamseldin, Hanan E., Sirr, Amy, AlAbdi, Lama, Lo, Russell S., Ewida, Nour, Al-Qahtani, Mashael, Hashem, Mais, Abdulwahab, Firdous, Aboyousef, Omar, Kaya, Namik, Monies, Dorota, Salem, May H., Al Harbi, Naffaa, Aldhalaan, Hesham M., Alzaidan, Hamad, Almanea, Hadeel M., Alsalamah, Abrar K., Al Mutairi, Fuad, Ismail, Samira, Abdel-Salam, Ghada M. H., Alhashem, Amal, Asery, Ali, Faqeih, Eissa, AlQassmi, Amal, Al-Hamoudi, Waleed, Algoufi, Talal, Shagrani, Mohammad, Dudley, Aimée M., Alkuraya, Fowzan S.
Publicado 2020

Complete genome sequences of microbacterium phages Tedro and BAjuniper

por Anderson, Grace M., Anderson, Olivia E., Bosma, Clayton A., Brouwer, Erin E., DeGroot, Kleyton M., Hede, Owen C., Jonouchi, Daiki, Kirkeby, Dylan J., Klinghagen, Jayron T., Kralik, Kate J., Kutz, Julia S., Lott, Olivia F., McKenney, Erika J., Pavik, Victoria L., Penner, Cayli H., Raymon, Garrett, Rozeboom, Leah B., Skrien, Jett L., Slight, Jessica K., Stokes, Maegan J., Tiensvold, Jonas D., Wajer, Kyra J., Trevino, Alaena L., Noordewier, Byron, Tolsma, Sara S.
Publicado 2023

Novel VPS13B Mutations in Three Large Pakistani Cohen Syndrome Families Suggests a Baloch Variant with Autistic-Like Features

por Rafiq, Muhammad Arshad, Leblond, Claire S, Saqib, Muhammad Arif Nadeem, Vincent, Akshita K., Ambalavanan, Amirthagowri, Khan, Falak Sher, Ayaz, Muhammad, Shaheen, Naseema, Spiegelman, Dan, Ali, Ghazanfar, Amin-ud-din, Muhammad, Laurent, Sandra, Mahmood, Huda, Christian, Mehtab, Ali, Nadir, Fennell, Alanna, Nanjiani, Zohair, Egger, Gerald, Caron, Chantal, Waqas, Ahmed, Ayub, Muhammad, Rasheed, Saima, Forgeot d’Arc, Baudouin, Johnson, Amelie, So, Joyce, Brohi, Muhammad Qasim, Mottron, Laurent, Ansar, Muhammad, Vincent, John B, Xiong, Lan
Publicado 2015

Biallelic mutations in valyl-tRNA synthetase gene VARS are associated with a progressive neurodevelopmental epileptic encephalopathy

por Friedman, Jennifer, Smith, Desiree E., Issa, Mahmoud Y., Stanley, Valentina, Wang, Rengang, Mendes, Marisa I., Wright, Meredith S., Wigby, Kristen, Hildreth, Amber, Crawford, John R., Koehler, Alanna E., Chowdhury, Shimul, Nahas, Shareef, Zhai, Liting, Xu, Zhiwen, Lo, Wing-Sze, James, Kiely N., Musaev, Damir, Accogli, Andrea, Guerrero, Kether, Tran, Luan T., Omar, Tarek E. I., Ben-Omran, Tawfeg, Dimmock, David, Kingsmore, Stephen F., Salomons, Gajja S., Zaki, Maha S., Bernard, Geneviève, Gleeson, Joseph G.
Publicado 2019

Functionally oriented analysis of cardiometabolic traits in a trans-ethnic sample

por Petty, Lauren E, Highland, Heather M, Gamazon, Eric R, Hu, Hao, Karhade, Mandar, Chen, Hung-Hsin, de Vries, Paul S, Grove, Megan L, Aguilar, David, Bell, Graeme I, Huff, Chad D, Hanis, Craig L, Doddapaneni, HarshaVardhan, Munzy, Donna M, Gibbs, Richard A, Ma, Jianzhong, Parra, Esteban J, Cruz, Miguel, Valladares-Salgado, Adan, Arking, Dan E, Barbeira, Alvaro, Im, Hae Kyung, Morrison, Alanna C, Boerwinkle, Eric, Below, Jennifer E
Publicado 2019

Genetic architecture of lipid traits in the Hispanic community health study/study of Latinos

por Graff, Mariaelisa, Emery, Leslie S., Justice, Anne E., Parra, Esteban, Below, Jennifer E., Palmer, Nicholette D., Gao, Chuan, Duan, Qing, Valladares-Salgado, Adan, Cruz, Miguel, Morrison, Alanna C., Boerwinkle, Eric, Whitsel, Eric A., Kooperberg, Charles, Reiner, Alex, Li, Yun, Rodriguez, Carlos Jose, Talavera, Gregory A., Langefeld, Carl D., Wagenknecht, Lynne E., Norris, Jill M., Taylor, Kent D., Papanicolaou, George, Kenny, Eimear, Loos, Ruth J. F., Chen, Yii-Der Ida, Laurie, Cathy, Sofer, Tamar, North, Kari E.
Publicado 2017

Safety of Hydroxychloroquine Among Outpatient Clinical Trial Participants for COVID-19

por Lofgren, Sarah M, Nicol, Melanie R, Bangdiwala, Ananta S, Pastick, Katelyn A, Okafor, Elizabeth C, Skipper, Caleb P, Pullen, Matthew F, Engen, Nicole W, Abassi, Mahsa, Williams, Darlisha A, Nascene, Alanna A, Axelrod, Margaret L, Lother, Sylvain A, MacKenzie, Lauren J, Drobot, Glen, Marten, Nicole, Cheng, Matthew P, Zarychanski, Ryan, Schwartz, Ilan S, Silverman, Michael, Chagla, Zain, Kelly, Lauren E, McDonald, Emily G, Lee, Todd C, Hullsiek, Kathy H, Boulware, David R, Rajasingham, Radha
Publicado 2020

Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells

por Green, Alanna C., Marttila, Petra, Kiweler, Nicole, Chalkiadaki, Christina, Wiita, Elisée, Cookson, Victoria, Lesur, Antoine, Eiden, Kim, Bernardin, François, Vallin, Karl S. A., Borhade, Sanjay, Long, Maeve, Ghahe, Elahe Kamali, Jiménez-Alonso, Julio J., Jemth, Ann-Sofie, Loseva, Olga, Mortusewicz, Oliver, Meyers, Marianne, Viry, Elodie, Johansson, Annika I., Hodek, Ondřej, Homan, Evert, Bonagas, Nadilly, Ramos, Louise, Sandberg, Lars, Frödin, Morten, Moussay, Etienne, Slipicevic, Ana, Letellier, Elisabeth, Paggetti, Jérôme, Sørensen, Claus Storgaard, Helleday, Thomas, Henriksson, Martin, Meiser, Johannes
Publicado 2023

Recessive nephrocerebellar syndrome on the Galloway-Mowat syndrome spectrum is caused by homozygous protein-truncating mutations of WDR73

por Jinks, Robert N., Puffenberger, Erik G., Baple, Emma, Harding, Brian, Crino, Peter, Fogo, Agnes B., Wenger, Olivia, Xin, Baozhong, Koehler, Alanna E., McGlincy, Madeleine H., Provencher, Margaret M., Smith, Jeffrey D., Tran, Linh, Al Turki, Saeed, Chioza, Barry A., Cross, Harold, Harlalka, Gaurav V., Hurles, Matthew E., Maroofian, Reza, Heaps, Adam D., Morton, Mary C., Stempak, Lisa, Hildebrandt, Friedhelm, Sadowski, Carolin E., Zaritsky, Joshua, Campellone, Kenneth, Morton, D. Holmes, Wang, Heng, Crosby, Andrew, Strauss, Kevin A.
Publicado 2015

Developing and Optimizing Innovative Tools to Address Familial Hypercholesterolemia Underdiagnosis: Identification Methods, Patient Activation, and Cascade Testing for Familial Hyp...

por Campbell-Salome, Gemme, Jones, Laney K., Masnick, Max F., Walton, Nephi A., Ahmed, Catherine D., Buchanan, Adam H., Brangan, Andrew, Esplin, Edward D., Kann, David G., Ladd, Ilene G., Kelly, Melissa A., Kindt, Iris, Kirchner, H. Lester, McGowan, Mary P., McMinn, Megan N., Morales, Ana, Myers, Kelly D., Oetjens, Matthew T., Rahm, Alanna Kulchak, Schmidlen, Tara J., Sheldon, Amanda, Simmons, Emilie, Snir, Moran, Strande, Natasha T., Walters, Nicole L., Wilemon, Katherine, Williams, Marc S., Gidding, Samuel S., Sturm, Amy C.
Publicado 2021

Identification of novel and rare variants associated with handgrip strength using whole genome sequence data from the NHLBI Trans-Omics in Precision Medicine (TOPMed) Program

por Sarnowski, Chloé, Chen, Han, Biggs, Mary L., Wassertheil-Smoller, Sylvia, Bressler, Jan, Irvin, Marguerite R., Ryan, Kathleen A., Karasik, David, Arnett, Donna K., Cupples, L. Adrienne, Fardo, David W., Gogarten, Stephanie M., Heavner, Benjamin D., Jain, Deepti, Kang, Hyun Min, Kooperberg, Charles, Mainous, Arch G., Mitchell, Braxton D., Morrison, Alanna C., O’Connell, Jeffrey R., Psaty, Bruce M., Rice, Kenneth, Smith, Albert V., Vasan, Ramachandran S., Windham, B. Gwen, Kiel, Douglas P., Murabito, Joanne M., Lunetta, Kathryn L.
Publicado 2021

Rare FGFR Oncogenic Alterations in Sequenced Pediatric Solid and Brain Tumors Suggest FGFR Is a Relevant Molecular Target in Childhood Cancer

por Lazo De La Vega, Lorena, Comeau, Hannah, Sallan, Sarah, Al-Ibraheemi, Alyaa, Gupta, Hersh, Li, Yvonne Y., Tsai, Harrison K., Kang, Wenjun, Ward, Abigail, Church, Alanna J., Kim, AeRang, Pinto, Navin R., Macy, Margaret E., Maese, Luke D., Sabnis, Amit J., Cherniack, Andrew D., Lindeman, Neal I., Anderson, Megan E., Cooney, Tabitha M., Yeo, Kee Kiat, Reaman, Gregory H., DuBois, Steven G., Collins, Natalie B., Johnson, Bruce E., Janeway, Katherine A., Forrest, Suzanne J.
Publicado 2022

JAK–STAT Signaling in Inflammatory Breast Cancer Enables Chemotherapy-Resistant Cell States

por Stevens, Laura E., Peluffo, Guillermo, Qiu, Xintao, Temko, Daniel, Fassl, Anne, Li, Zheqi, Trinh, Anne, Seehawer, Marco, Jovanović, Bojana, Alečković, Maša, Wilde, Callahan M., Geck, Renee C., Shu, Shaokun, Kingston, Natalie L., Harper, Nicholas W., Almendro, Vanessa, Pyke, Alanna L., Egri, Shawn B., Papanastasiou, Malvina, Clement, Kendell, Zhou, Ningxuan, Walker, Sarah, Salas, Jacqueline, Park, So Yeon, Frank, David A., Meissner, Alexander, Jaffe, Jacob D., Sicinski, Piotr, Toker, Alex, Michor, Franziska, Long, Henry W., Overmoyer, Beth A., Polyak, Kornelia
Publicado 2023

Decision-support tools to build climate resilience against emerging infectious diseases in Europe and beyond

por Rocklöv, Joacim, Semenza, Jan C., Dasgupta, Shouro, Robinson, Elizabeth J.Z., Abd El Wahed, Ahmed, Alcayna, Tilly, Arnés-Sanz, Cristina, Bailey, Meghan, Bärnighausen, Till, Bartumeus, Frederic, Borrell, Carme, Bouwer, Laurens M., Bretonnière, Pierre-Antoine, Bunker, Aditi, Chavardes, Chloe, van Daalen, Kim R., Encarnação, João, González-Reviriego, Nube, Guo, Junwen, Johnson, Katie, Koopmans, Marion P.G., Máñez Costa, María, Michaelakis, Antonios, Montalvo, Tomás, Omazic, Anna, Palmer, John R.B., Preet, Raman, Romanello, Marina, Shafiul Alam, Mohammad, Sikkema, Reina S., Terrado, Marta, Treskova, Marina, Urquiza, Diana, Lowe, Rachel
Publicado 2023

Inherited coding variants at the CDKN2A locus influence susceptibility to acute lymphoblastic leukaemia in children

por Xu, Heng, Zhang, Hui, Yang, Wenjian, Yadav, Rachita, Morrison, Alanna C., Qian, Maoxiang, Devidas, Meenakshi, Liu, Yu, Perez-Andreu, Virginia, Zhao, Xujie, Gastier-Foster, Julie M., Lupo, Philip J., Neale, Geoff, Raetz, Elizabeth, Larsen, Eric, Bowman, W. Paul, Carroll, William L., Winick, Naomi, Williams, Richard, Hansen, Torben, Holm, Jens-Christian, Mardis, Elaine, Fulton, Robert, Pui, Ching-Hon, Zhang, Jinghui, Mullighan, Charles G., Evans, William E., Hunger, Stephen P., Gupta, Ramneek, Schmiegelow, Kjeld, Loh, Mignon L., Relling, Mary V., Yang, Jun J.
Publicado 2015