“…Where the modes of regulation of a key gene are still not completely characterized despite decades of research, such as in CAP59, the presence of a phenotypically monitored, lone SNP in a strategic position within an almost SNP-less region can give potentially precious hints where otherwise none exist; we illustrate this strategy of SNP-focused local exploration for the promoter/enhancer and currently used MLST amplicon of CAP59. …”
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“…The booster dose significantly improved the median neutralizing antibody (NAb) response in patients with MM (27.1% before to 96.7% after the third dose p<0.001). Importantly, almost half of the patients with suboptimal NAb responses at one month after the second dose of BNT162b2 developed NAb titers of at least 50% at one month after the booster dose. …”
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“…Both groups were similar in almost all characteristics at baseline, and the median (IQR) follow-up was 6.4 (6.0-6.7) years. …”
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“…The DSC was calculated for three functional regions (high, moderate, and low) separated by an almost equal volume. The coefficient of variation was defined as prediction uncertainty, and these average values were calculated within three functional regions. …”
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“…However, in studies from lower-income countries, patient intervals were consistently 1.5 to 4 times longer for almost all cancer sites. The majority of data on the diagnostic and treatment intervals came from high-income countries. …”
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“…In the national rollout, 22.17% (781/3522) of the eligible caregivers answered the web-based survey and reported that the messages had been useful in managing stress (mean score 4.3, SD 0.8), helping them take care of themselves (mean score 4.3, SD 0.8) and loved ones (mean score 4.2, SD 0.8), and making them feel cared for (mean score 4.5, SD 0.8). Almost two-thirds (509/778, 65.4%) of the participants tried all or most of the strategies. …”
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“…Older obese men had an almost three-fold higher risk of developing diabetes than younger obese men (HR=2.72 [95%CI: 1.12, 6.63]), accounting for race, education, height, weight and %TFM. …”
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“…While efavirenz CYP3A activation was relatively fast and short, reaching a maximum after approximately 2–3 h, the induction effect of rifampicin could only be observed after 22 h, with a maximum after approximately 28–30 h followed by a steep drop to almost baseline within 1–2 h. In contrast, the inhibitory impact of both oral and intravenous voriconazole was prolonged with a steady inhibition of CYP3A activity followed by a gradual increase in the inhibitory effect until the end of sampling at 8 h. …”
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“…With 19.3 million new cases and almost 10 million deaths in 2020, cancer has become a leading cause of death today. …”
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“…Males constituted 78% of the population cohort and almost 45% of participants were aged <45 years. Patients aged ≤45 years displayed higher mean sd-LDL levels of 30.40 ± 14.18 mg/dL versus patients aged >45 years with mean sd-LDL levels of 28.01 ± 11.58 mg/dL, but the difference was not statistically significant (p = 0.19). …”
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“…Remarkably, those of bisphenol Z (BPZ), BPA, and BPM reached almost 100% after 90 min. The adsorption between the BPs and CoNi@NGC was mainly governed by hydrogen bonds, electrostatic interactions, and π-π conjugation. …”
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“…In the 47 non-immunocompromised patients in which 2 or more viruses were detected, mortality was almost 25% and in the 31 immunocompromised patients mortality neared 40%. …”
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“…CONCLUSION: While colonization with MRSA and VRE in liver transplant was not associated with increase mortality, CRE colonization was associated with almost 6-fold increased risk of death. These data should be taken into account when stratifying the risk of transplant. …”
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“…BACKGROUND: Atrial fibrillation (AF) is responsible for almost one third of all strokes, with the left atrial appendage (LAA) being the primary thromboembolic source due to localised stimulation of prothrombotic mechanisms; blood stasis, hypercoagulability and endothelial damage, known as Virchow's triad. …”
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“…BACKGROUND: High-risk human papillomavirus (hrHPV) infection is a necessary cause of almost all cervical cancers. Relative to hrHPV 16/18 infection, non-16/18 hrHPV infection is of less concern. …”
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“…Most respondents (1125/1259, 89.4%) reported being very comfortable and confident using computers, over half (675/1259, 53.6%) reported being an early adopter of technology, and almost half (595/1259, 47.3%) reported having used a VHA health-related app. …”
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“…Unlike toddlers without ASD, who almost uniformly attended to motherese speech with a median level of 82.25% and 80.75% across the 2 tests, among toddlers with ASD, there was a wide range, spanning 0% to 100%. …”
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“…As these studies considered different interventions we were unable to carry out any meta‐analysis, and for almost all outcomes the certainty of the evidence was very low. …”
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“…RESULTS: In each year, the sample included a weighted count of almost 25 million adolescents, with 50.9% (95% CI, 50.2%-51.6%) males and 24.7% (95% CI, 23.8%-25.6%) Hispanic adolescents, 13.5% (95% CI, 12.8%-14.2%) non-Hispanic Black adolescents, and 51.8% (95% CI, 50.8%-52.8%) non-Hispanic White adolescents in 2019. …”
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“…The percentage of inhibitory activities at 5 µM concentration against the COX2 enzyme was in the range of 53.9–81.5%, while the percentage against the COX-1 enzyme was 14.7–74.8%. That means almost all of our compounds have selective inhibition activities against the COX-2 enzyme, and the most selective compound was 2f, with selectivity ratio (SR) value of 3.67 at 5 µM concentration, which has a bulky group of trimethoxy on the phenyl ring that could not bind well with the COX-1 enzyme. …”
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