Multiple Germline Events Contribute to Cancer Development in Patients with Li-Fraumeni Syndrome

por Subasri, Vallijah, Light, Nicholas, Kanwar, Nisha, Brzezinski, Jack, Luo, Ping, Hansford, Jordan R., Cairney, Elizabeth, Portwine, Carol, Elser, Christine, Finlay, Jonathan L., Nichols, Kim E., Alon, Noa, Brunga, Ledia, Anson, Jo, Kohlmann, Wendy, de Andrade, Kelvin C., Khincha, Payal P., Savage, Sharon A., Schiffman, Joshua D., Weksberg, Rosanna, Pugh, Trevor J., Villani, Anita, Shlien, Adam, Goldenberg, Anna, Malkin, David
Publicado 2023

Computational and Functional Analyses of HER2 Mutations Reveal Allosteric Activation Mechanisms and Altered Pharmacologic Effects

por Ishiyama, Noboru, O'Connor, Matthew, Salomatov, Andrei, Romashko, Darlene, Thakur, Shalabh, Mentes, Ahmet, Hopkins, Julia F., Frampton, Garrett M., Albacker, Lee A., Kohlmann, Anna, Roberts, Christopher, Buck, Elizabeth
Publicado 2023

Comprehensive Metabolic Tracing Reveals the Origin and Catabolism of Cysteine in Mammalian Tissues and Tumors

por Yoon, Sang Jun, Combs, Joseph A., Falzone, Aimee, Prieto-Farigua, Nicolas, Caldwell, Samantha, Ackerman, Hayley D., Flores, Elsa R., DeNicola, Gina M.
Publicado 2023

Spatial Positioning of Immune Hotspots Reflects the Interplay between B and T Cells in Lung Squamous Cell Carcinoma

por Zhang, Hanyun, AbdulJabbar, Khalid, Moore, David A., Akarca, Ayse, Enfield, Katey S.S., Jamal-Hanjani, Mariam, Raza, Shan E. Ahmed, Veeriah, Selvaraju, Salgado, Roberto, McGranahan, Nicholas, Le Quesne, John, Swanton, Charles, Marafioti, Teresa, Yuan, Yinyin
Publicado 2023

Enhancer Coamplification and Hijacking Promote Oncogene Expression in Liposarcoma

por Liu, Tingting, Wang, Juan, Yang, Hongbo, Jin, Qiushi, Wang, Xiaotao, Fu, Yihao, Luan, Yu, Wang, Qixuan, Youngblood, Mark W., Lu, Xinyan, Casadei, Lucia, Pollock, Raphael, Yue, Feng
Publicado 2023

circFNDC3B Accelerates Vasculature Formation and Metastasis in Oral Squamous Cell Carcinoma

por Li, Xiang, Wang, Chenxing, Zhang, Hang, Li, Yangjie, Hou, Deqiang, Liu, Dingshan, Xu, Rongyao, Cheng, Jie, Liu, Laikui, Fu, Yu, Ye, Jinhai, Jiang, Hongbing
Publicado 2023

Polyunsaturated Fatty Acid–Bound α-Fetoprotein Promotes Immune Suppression by Altering Human Dendritic Cell Metabolism

por Munson, Paul V., Adamik, Juraj, Hartmann, Felix J., Favaro, Patricia M.B., Ho, Daniel, Bendall, Sean C., Combes, Alexis J., Krummel, Matthew F., Zhang, Karen, Kelley, Robin K., Butterfield, Lisa H.
Publicado 2023

Interethnic Differences in Bladder Cancer Incidence and the Association between Type 2 Diabetes and Bladder Cancer in the Multiethnic Cohort Study

por Bogumil, David, Cortessis, Victoria K., Wilkens, Lynne R., Le Marchand, Loïc, Haiman, Christopher A., Maskarinec, Gertraud, Setiawan, Veronica Wendy
Publicado 2023

Reverse Translation Identifies the Synergistic Role of Immune Checkpoint Blockade and IL15 to Enhance Immunotherapy of Ovarian Cancer

por Felices, Martin, Wesley, Erin, Bendzick, Laura E., Kodal, Behiye, Hopps, Rachel, Grzywacz, Bartosz, Hinderlie, Peter, Miller, Jeffrey S., Geller, Melissa A.
Publicado 2023

HDAC3 Inhibition Promotes Antitumor Immunity by Enhancing CXCL10-Mediated Chemotaxis and Recruiting of Immune Cells

por Li, Lili, Hao, Shumin, Gao, Meiling, Liu, Junxiao, Xu, Xin, Huang, Jianfei, Cheng, Genhong, Yang, Heng
Publicado 2023

Myeloid-Derived Suppressor–Cell Dynamics Control Outcomes in the Metastatic Niche

por Kreger, Jesse, Roussos Torres, Evanthia T., MacLean, Adam L.
Publicado 2023

Low TCR Binding Strength Results in Increased Progenitor-like CD8(+) Tumor-Infiltrating Lymphocytes

por Hay, Zachary L.Z., Knapp, Jennifer R., Magallon, Roman E., O'Connor, Brian P., Slansky, Jill E.
Publicado 2023

Driver Mutations Dictate the Immunologic Landscape and Response to Checkpoint Immunotherapy of Glioblastoma

por Yeo, Alan T., Shah, Rushil, Aliazis, Konstantinos, Pal, Rinku, Xu, Tuoye, Zhang, Piyan, Rawal, Shruti, Rose, Christopher M., Varn, Frederick S., Appleman, Vicky A., Yoon, Joon, Varma, Hemant, Gygi, Steven P., Verhaak, Roel G.W., Boussiotis, Vassiliki A., Charest, Al
Publicado 2023

SWI/SNF Complex Genomic Alterations as a Predictive Biomarker for Response to Immune Checkpoint Inhibitors in Multiple Cancers

por Wang, Di, Wang, Jianchao, Zhou, Dongmei, Wu, Zhixian, Liu, Wei, Chen, Yanping, Chen, Gang, Zhang, Jing
Publicado 2023

Ultra High-plex Spatial Proteogenomic Investigation of Giant Cell Glioblastoma Multiforme Immune Infiltrates Reveals Distinct Protein and RNA Expression Profiles

por Bonnett, Shilah A., Rosenbloom, Alyssa B., Ong, Giang T., Conner, Mark, Rininger, Aric B.E., Newhouse, Daniel, New, Felicia, Phan, Chi Q., Ilcisin, Saskia, Sato, Hiromi, Lyssand, John S., Geiss, Gary, Beechem, Joseph M.
Publicado 2023

IMiDs Augment CD3-Bispecific Antibody–Induced CD8(+) T-Cell Cytotoxicity and Expansion by Enhancing IL2 Production

por Li, Ji, Slaga, Dionysos, Johnston, Jennifer, Junttila, Teemu T.
Publicado 2023

Pharmacokinetic/Pharmacodynamic Analysis of Savolitinib plus Osimertinib in an EGFR Mutation–Positive, MET-Amplified Non–Small Cell Lung Cancer Model

por Jones, Rhys D.O., Petersson, Klas, Tabatabai, Areya, Bao, Larry, Tomkinson, Helen, Schuller, Alwin G.
Publicado 2023

Preclinical Evaluation of ON203, A Novel Bioengineered mAb Targeting Oxidized Macrophage Migration Inhibitory Factor as an Anticancer Therapeutic

por Rossmueller, Gregor, Mirkina, Irina, Maurer, Barbara, Hoeld, Verena, Mayer, Julia, Thiele, Michael, Kerschbaumer, Randolf J., Schinagl, Alexander
Publicado 2023

Targeting Senescence as a Therapeutic Opportunity for Triple-Negative Breast Cancer

por de Paula, Bruno, Kieran, Rosalind, Koh, Samantha Shui Yuan, Crocamo, Susanne, Abdelhay, Eliana, Muñoz-Espín, Daniel
Publicado 2023

Small-Molecule–Mediated Stabilization of PP2A Modulates the Homologous Recombination Pathway and Potentiates DNA Damage-Induced Cell Death

por Avelar, Rita A., Armstrong, Amy J., Carvette, Gracie, Gupta, Riya, Puleo, Noah, Colina, Jose A., Joseph, Peronne, Sobeck, Alexander M., O'Connor, Caitlin M., Raines, Brynne, Gandhi, Agharnan, Dziubinski, Michele L., Ma, Daniel S., Resnick, Kimberly, Singh, Sareena, Zanotti, Kristine, Nagel, Christa, Waggoner, Steven, Thomas, Daffyd G., Skala, Stephanie L., Zhang, Junran, Narla, Goutham, DiFeo, Analisa
Publicado 2023