iBRIDGE: A Data Integration Method to Identify Inflamed Tumors from Single-cell RNA-Seq Data and Differentiate Cell Type–Specific Markers of Immune-Cell Infiltration

por Turan, Tolga, Kongpachith, Sarah, Halliwill, Kyle, McLaughlin, Robert T., Binnewies, Mikhail, Reddy, Dhemath, Zhao, Xi, Mathew, Rebecca, Ye, Shiming, Jacob, Howard J., Samayoa, Josue
Publicado 2023

Breast Cancer Stem Cell–Derived Tumors Escape from γδ T-cell Immunosurveillance In Vivo by Modulating γδ T-cell Ligands

por Raute, Katrin, Strietz, Juliane, Parigiani, Maria Alejandra, Andrieux, Geoffroy, Thomas, Oliver S., Kistner, Klaus M., Zintchenko, Marina, Aichele, Peter, Hofmann, Maike, Zhou, Houjiang, Weber, Wilfried, Boerries, Melanie, Swamy, Mahima, Maurer, Jochen, Minguet, Susana
Publicado 2023

DAB2IP Is a Bifunctional Tumor Suppressor That Regulates Wild-Type RAS and Inflammatory Cascades in KRAS Mutant Colon Cancer

por Miller, Abigail L., Perurena, Naiara, Gardner, Alycia, Hinoue, Toshinori, Loi, Patrick, Laird, Peter W., Cichowski, Karen
Publicado 2023

T Cells Expressing a Modified FcγRI Exert Antibody-Dependent Cytotoxicity and Overcome the Limitations of CAR T-cell Therapy against Solid Tumors

por Rasoulouniriana, Diana, Santana-Magal, Nadine, Gutwillig, Amit, Farhat-Younis, Leen, Tal, Lior, Amar, Sarah, Milyavsky, Michael, Muddineni, Siva Sai Naga Anurag, Solomon, Neta, Shpilt, Hana, Dotan, Shahar, Pilpel, Noam, Waskow, Claudia, Feinmesser, Meora, Rider, Peleg, Carmi, Yaron
Publicado 2023

N-of-1 Trials in Cancer Drug Development

por Gouda, Mohamed A., Buschhorn, Lars, Schneeweiss, Andreas, Wahida, Adam, Subbiah, Vivek
Publicado 2023

Single-Cell RNA Sequencing Unifies Developmental Programs of Esophageal and Gastric Intestinal Metaplasia

por Nowicki-Osuch, Karol, Zhuang, Lizhe, Cheung, Tik Shing, Black, Emily L., Masqué-Soler, Neus, Devonshire, Ginny, Redmond, Aisling M., Freeman, Adam, di Pietro, Massimilliano, Pilonis, Nastazja, Januszewicz, Wladyslaw, O'Donovan, Maria, Tavaré, Simon, Shields, Jacqueline D., Fitzgerald, Rebecca C.
Publicado 2023

Late-Stage Metastatic Melanoma Emerges through a Diversity of Evolutionary Pathways

por Spain, Lavinia, Coulton, Alexander, Lobon, Irene, Rowan, Andrew, Schnidrig, Desiree, Shepherd, Scott T.C., Shum, Benjamin, Byrne, Fiona, Goicoechea, Maria, Piperni, Elisa, Au, Lewis, Edmonds, Kim, Carlyle, Eleanor, Hunter, Nikki, Renn, Alexandra, Messiou, Christina, Hughes, Peta, Nobbs, Jaime, Foijer, Floris, van den Bos, Hilda, Wardenaar, Rene, Spierings, Diana C.J., Spencer, Charlotte, Schmitt, Andreas M., Tippu, Zayd, Lingard, Karla, Grostate, Lauren, Peat, Kema, Kelly, Kayleigh, Sarker, Sarah, Vaughan, Sarah, Mangwende, Mary, Terry, Lauren, Kelly, Denise, Biano, Jennifer, Murra, Aida, Korteweg, Justine, Lewis, Charlotte, O'Flaherty, Molly, Cattin, Anne-Laure, Emmerich, Max, Gerard, Camille L., Pallikonda, Husayn Ahmed, Lynch, Joanna, Mason, Robert, Rogiers, Aljosja, Xu, Hang, Huebner, Ariana, McGranahan, Nicholas, Al Bakir, Maise, Murai, Jun, Naceur-Lombardelli, Cristina, Borg, Elaine, Mitchison, Miriam, Moore, David A., Falzon, Mary, Proctor, Ian, Stamp, Gordon W.H., Nye, Emma L., Young, Kate, Furness, Andrew J.S., Pickering, Lisa, Stewart, Ruby, Mahadeva, Ula, Green, Anna, Larkin, James, Litchfield, Kevin, Swanton, Charles, Jamal-Hanjani, Mariam, Turajlic, Samra
Publicado 2023

Combinatorial BCL2 Family Expression in Acute Myeloid Leukemia Stem Cells Predicts Clinical Response to Azacitidine/Venetoclax

por Waclawiczek, Alexander, Leppä, Aino-Maija, Renders, Simon, Stumpf, Karolin, Reyneri, Cecilia, Betz, Barbara, Janssen, Maike, Shahswar, Rabia, Donato, Elisa, Karpova, Darja, Thiel, Vera, Unglaub, Julia M., Grabowski, Susanna, Gryzik, Stefanie, Vierbaum, Lisa, Schlenk, Richard F., Röllig, Christoph, Hundemer, Michael, Pabst, Caroline, Heuser, Michael, Raffel, Simon, Müller-Tidow, Carsten, Sauer, Tim, Trumpp, Andreas
Publicado 2023

BCA101 Is a Tumor-Targeted Bifunctional Fusion Antibody That Simultaneously Inhibits EGFR and TGFβ Signaling to Durably Suppress Tumor Growth

por Boreddy, Srinivas Reddy, Nair, Reshmi, Pandey, Prashant Kumar, Kuriakose, Anshu, Marigowda, Shivakumar Bhadravathi, Dey, Chaitali, Banerjee, Arindam, Kulkarni, Hanumant, Sagar, Milind, Krishn, Shiv Ram, Rao, Shruthi, AR, Madhukara, Tiwari, Vinita, Alke, Bhavna, MV, Prashantha Kumar, Shri, Meena, Dhamne, Chaitrali, Patel, Sonal, Sharma, Pinky, Periyasamy, Sankar, Bhatnagar, Jaya, Kuriakose, Moni Abraham, Reddy, Ram Bhupal, Suresh, Amritha, Sreenivas, Suma, Govindappa, Nagaraja, Moole, Praveen Reddy, Bughani, Usha, Tan, Seng-Lai, Nair, Pradip
Publicado 2023

The m(6)A Reader YTHDF2 Promotes Bladder Cancer Progression by Suppressing RIG-I–Mediated Immune Response

por Zhang, Lei, Li, Yuqing, Zhou, Lingli, Zhou, Houhong, Ye, Liefu, Ou, Tong, Hong, Huaishan, Zheng, Shiwen, Zhou, Ziyu, Wu, Kang, Yan, Zeqin, Thiery, Jean Paul, Cui, Jun, Wu, Song
Publicado 2023

Analysis of Donor Pancreata Defines the Transcriptomic Signature and Microenvironment of Early Neoplastic Lesions

por Carpenter, Eileen S., Elhossiny, Ahmed M., Kadiyala, Padma, Li, Jay, McGue, Jake, Griffith, Brian D., Zhang, Yaqing, Edwards, Jacob, Nelson, Sarah, Lima, Fatima, Donahue, Katelyn L., Du, Wenting, Bischoff, Allison C., Alomari, Danyah, Watkoske, Hannah R., Mattea, Michael, The, Stephanie, Espinoza, Carlos E., Barrett, Meredith, Sonnenday, Christopher J., Olden, Nicholas, Chen, Chin-Tung, Peterson, Nicole, Gunchick, Valerie, Sahai, Vaibhav, Rao, Arvind, Bednar, Filip, Shi, Jiaqi, Frankel, Timothy L., Pasca di Magliano, Marina
Publicado 2023

A Novel Class of Ribosome Modulating Agents Exploits Cancer Ribosome Heterogeneity to Selectively Target the CMS2 Subtype of Colorectal Cancer

por Terzo, Esteban, Apte, Shruti A., Padhye, Simran, Rashed, Saleh, Austin, Wesley, Caponegro, Michael, Reddy, Anupama, Shi, Shuhao, Wang, Christy, Clark, Roger B., Sidransky, David, Modur, Vijay, Badarinarayana, Vasudeo
Publicado 2023

Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

por Finlay, John B., Abi Hachem, Ralph, Jang, David W., Osazuwa-Peters, Nosayaba, Goldstein, Bradley J.
Publicado 2023

Safety and Clinical Response to Combined Immunotherapy with Autologous iNKT Cells and PD-1(+)CD8(+) T Cells in Patients Failing First-line Chemotherapy in Stage IV Pancreatic Cance...

por Wang, Jing, Cheng, Xiaobo, Jin, Yanling, Xia, Bili, Qin, Ran, Zhang, Wei, Hu, Huiliang, Mao, Xiaoting, Zhou, Liting, Yan, Jia, Zhang, Xiaoyan, Xu, Jianqing
Publicado 2023

A Phase I/II Clinical Trial of Pembrolizumab and Cabozantinib in Metastatic Renal Cell Carcinoma

por Kessler, Elizabeth R., Callihan, Eryn, Hu, Junxiao, Eule, Corbin, Srivastava, Geetika, Kemme, Douglas J., Iruku, Praveena, Rana, Vishal, Moore, James, Schuster, Steven R., Amirault, Mali, Flaig, Thomas W., Lam, Elaine T.
Publicado 2023

Antidepressant Use and Lung Cancer Risk and Survival: A Meta-analysis of Observational Studies

por Lee, Eunkyung, Park, Yongho, Li, David, Rodriguez-Fuguet, Alice, Wang, Xiaochuan, Zhang, Wen Cai
Publicado 2023

Cancer's Dark Matter: Lighting the Abyss Unveils Universe of New Therapies

por Fox, Bernard A., Urba, Walter J., Jensen, Shawn M., Page, David B., Curti, Brendan D., Sanborn, Rachel E., Leidner, Rom S.
Publicado 2023

Expression and Therapeutic Targeting of TROP-2 in Treatment-Resistant Prostate Cancer

por Sperger, Jamie M., Helzer, Kyle T., Stahlfeld, Charlotte N., Jiang, Dawei, Singh, Anupama, Kaufmann, Katherine R., Niles, David J., Heninger, Erika, Rydzewski, Nicholas R., Wang, Liguo, Wang, Liewei, Yang, Rendong, Ren, Yanan, Engle, Jonathan W., Huang, Peng, Kyriakopoulos, Christos E., Slovin, Susan F., Soule, Howard R., Zhao, Shuang G., Kohli, Manish, Tagawa, Scott T., Cai, Weibo, Dehm, Scott M., Lang, Joshua M.
Publicado 2023

Antitumor Efficacy of Dual Blockade with Encorafenib + Cetuximab in Combination with Chemotherapy in Human BRAF(V600E)-Mutant Colorectal Cancer

por Napolitano, Stefania, Woods, Melanie, Lee, Hey Min, De Falco, Vincenzo, Martini, Giulia, Della Corte, Carminia Maria, Martinelli, Erika, Famiglietti, Vincenzo, Ciardiello, Davide, Anderson, Amanda, Fowlkes, Natalie Wall, Villareal, Oscar Eduardo, Sorokin, Alexey, Kanikarla, Preeti, Coker, Olu, Morris, Van, Altucci, Lucia, Tabernero, Josep, Troiani, Teresa, Ciardiello, Fortunato, Kopetz, Scott
Publicado 2023

Dynamics of Sequence and Structural Cell-Free DNA Landscapes in Small-Cell Lung Cancer

por Sivapalan, Lavanya, Iams, Wade T., Belcaid, Zineb, Scott, Susan C., Niknafs, Noushin, Balan, Archana, White, James R., Kopparapu, Prasad, Cann, Christopher, Landon, Blair V., Pereira, Gavin, Velculescu, Victor E., Hann, Christine L., Lovly, Christine M., Anagnostou, Valsamo
Publicado 2023