TIGIT Expression Delineates T-cell Populations with Distinct Functional and Prognostic Impact in Pancreatic Cancer

por Heiduk, Max, Klimova, Anna, Reiche, Charlotte, Digomann, David, Beer, Carolin, Aust, Daniela E., Distler, Marius, Weitz, Jürgen, Seifert, Adrian M., Seifert, Lena
Publicado 2023

Targeting CD44 Variant 5 with an Antibody–Drug Conjugate Is an Effective Therapeutic Strategy for Intrahepatic Cholangiocarcinoma

por Bei, Yuncheng, He, Jian, Dong, Xuhui, Wang, Yuxin, Wang, Sijie, Guo, Wan, Cai, Chengjie, Xu, Zhiye, Wei, Jia, Liu, Baorui, Zhang, Nan, Shen, Pingping
Publicado 2023

Immune Checkpoint Inhibitors and the Exposome: Host-Extrinsic Factors Determine Response, Survival, and Toxicity

por Pizzutilo, Elio Gregory, Romanò, Rebecca, Roazzi, Laura, Agostara, Alberto G., Oresti, Sara, Zeppellini, Annalisa, Giannetta, Laura, Cerea, Giulio, Signorelli, Diego, Siena, Salvatore, Sartore-Bianchi, Andrea
Publicado 2023

Siglec-15 Promotes Evasion of Adaptive Immunity in B-cell Acute Lymphoblastic Leukemia

por Pillsbury, Claire E., Dougan, Jodi, Rabe, Jennifer L., Fonseca, Jairo A., Zhou, Chengjing, Evans, Alyssa N., Abukharma, Hasan, Ichoku, Ona, Gonzalez-Flamenco, Gloria, Park, Sunita I., Aljudi, Ahmed, DeRyckere, Deborah, Castellino, Sharon M., Rafiq, Sarwish, Langermann, Solomon, Liu, Linda N., Henry, Curtis J., Porter, Christopher C.
Publicado 2023

Dual Recombinase–Based Mouse Models Help Decipher Cancer Biology and Targets for Therapy

por Sket, Tina, Falcomatà, Chiara, Saur, Dieter
Publicado 2023

A Th1-like CD4(+) T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer

por Yanagihara, Akitoshi, Yamasaki, Satoshi, Hashimoto, Kosuke, Taguchi, Ryo, Umesaki, Tetsuya, Imai, Hisao, Kaira, Kyoichi, Nitanda, Hiroyuki, Sakaguchi, Hirozo, Ishida, Hironori, Kobayashi, Kunihiko, Horimoto, Katsuhisa, Kagamu, Hiroshi
Publicado 2023

Metronomic Administration of Topotecan Alone and in Combination with Docetaxel Inhibits Epithelial–mesenchymal Transition in Aggressive Variant Prostate Cancers

por Mitra Ghosh, Taraswi, Mazumder, Suman, Davis, Joshua, Yadav, Jyoti, Akinpelu, Ayuba, Alnaim, Ahmed, Kumar, Harish, Waliagha, Razan, Church Bird, Allison E., Rais-Bahrami, Soroush, Bird, R. Curtis, Mistriotis, Panagiotis, Mishra, Amarjit, Yates, Clayton C., Mitra, Amit K., Arnold, Robert D.
Publicado 2023

Salvage Ipilimumab plus Nivolumab after Anti-PD-1/PD-L1 Therapy in Advanced Hepatocellular Carcinoma

por Alden, Stephanie L., Lim, Mir, Kao, Chester, Shu, Daniel, Singal, Amit G., Noonan, Anne, Griffith, Paige, Baretti, Marina, Ho, Won Jin, Kamel, Ihab, Yarchoan, Mark, Hsiehchen, David
Publicado 2023

Correction: Efficacy and Safety of Patritumab Deruxtecan (HER3-DXd) in EGFR Inhibitor–Resistant, EGFR-Mutated Non–Small Cell Lung Cancer

Publicado 2022

Correction: Phase I Trial of ALRN-6924, a Dual Inhibitor of MDMX and MDM2, in Patients with Solid Tumors and Lymphomas Bearing Wild-type TP53

por Saleh, Mansoor N., Patel, Manish R., Bauer, Todd M., Goel, Sanjay, Falchook, Gerald S., Shapiro, Geoffrey I., Chung, Ki Y., Infante, Jeffrey R., Conry, Robert M., Rabinowits, Guilherme, Hong, David S., Wang, Judy S., Steidl, Ulrich, Walensky, Loren D., Naik, Gurudatta, Guerlavais, Vincent, Vukovic, Vojislav, Annis, D. Allen, Aivado, Manuel, Meric-Bernstam, Funda
Publicado 2022

Correction: Updated Integrated Analysis of the Efficacy and Safety of Entrectinib in Patients with NTRK Fusion–Positive Solid Tumors

por Demetri, George D., De Braud, Filippo, Drilon, Alexander, Siena, Salvatore, Patel, Manish R., Cho, Byoung Chul, Liu, Stephen V., Ahn, Myung-Ju, Chiu, Chao-Hua, Lin, Jessica J., Goto, Koichi, Lee, Jeeyun, Bazhenova, Lyudmila, John, Thomas, Fakih, Marwan, Chawla, Sant P., Dziadziuszko, Rafal, Seto, Takashi, Heinzmann, Sebastian, Pitcher, Bethany, Chen, David, Wilson, Timothy R., Rolfo, Christian
Publicado 2022

Sequential Chromogenic IHC: Spatial Analysis of Lymph Nodes Identifies Contact Interactions between Plasmacytoid Dendritic Cells and Plasmablasts

por Claudio, Natalie, Nguyen, My-Tien, Wanner, Adrian, Pucci, Ferdinando
Publicado 2023

Immunologic Characterization and T cell Receptor Repertoires of Expanded Tumor-infiltrating Lymphocytes in Patients with Renal Cell Carcinoma

por Lee, Moon Hee, Theodoropoulos, Jason, Huuhtanen, Jani, Bhattacharya, Dipabarna, Järvinen, Petrus, Tornberg, Sara, Nísen, Harry, Mirtti, Tuomas, Uski, Ilona, Kumari, Anita, Peltonen, Karita, Draghi, Arianna, Donia, Marco, Kreutzman, Anna, Mustjoki, Satu
Publicado 2023

Clinically Defined Mutations in MEN1 Alter Its Tumor-suppressive Function Through Increased Menin Turnover

por Duan, Suzann, Sheriff, Sulaiman, Elvis-Offiah, Uloma B., Witten, Brandon L., Sawyer, Travis W., Sundaresan, Sinju, Cierpicki, Tomasz, Grembecka, Jolanta, Merchant, Juanita L.
Publicado 2023

Validation of Immunotherapy Response Score as Predictive of Pan-solid Tumor Anti-PD-1/PD-L1 Benefit

por Bulen, Benjamin J., Khazanov, Nickolay A., Hovelson, Daniel H., Lamb, Laura E., Matrana, Marc, Burkard, Mark E., Yang, Eddy Shih-Hsin, Edenfield, William J., Claire Dees, Elizabeth, Onitilo, Adedayo A., Buchschacher, Gary L., Miller, Alan M., Parsons, Benjamin M., Wassenaar, Timothy R., Suga, Jennifer M., Siegel, Robert D., Irvin, William, Nair, Suresh, Slim, Jennifer N., Misleh, Jamal, Khatri, Jamil, Masters, Gregory A., Thomas, Sachdev, Safa, Malek M., Anderson, Daniel M., Mowers, Jonathan, Dusenbery, Anna C., Drewery, Stephanie, Plouffe, Komal, Reeder, Travis, Vakil, Hana, Patrias, Lynnae, Falzetta, Amanda, Hamilton, Ryan, Kwiatkowski, Kat, Johnson, D. Bryan, Rhodes, Daniel R., Tomlins, Scott A.
Publicado 2023

Proteogenomic Approaches for the Identification of NF1/Neurofibromin-depleted Estrogen Receptor–positive Breast Cancers for Targeted Treatment

por Kim, Beom-Jun, Zheng, Ze-Yi, Lei, Jonathan T., Holt, Matthew V., Chen, Anran, Peng, Jianheng, Fandino, Diana, Singh, Purba, Kennedy, Hilda, Dou, Yongchao, Chica-Parrado, María del Rosario, Bikorimana, Emmanuel, Ye, Dan, Wang, Yunguan, Hanker, Ariella B., Mohamed, Nada, Hilsenbeck, Susan G., Lim, Bora, Asirvatham, Jaya Ruth, Sreekumar, Arun, Zhang, Bing, Miles, George, Anurag, Meenakshi, Ellis, Matthew J., Chang, Eric C.
Publicado 2023

Integrated Multi-omics Analysis of Early Lung Adenocarcinoma Links Tumor Biological Features with Predicted Indolence or Aggressiveness

por Senosain, Maria-Fernanda, Zou, Yong, Patel, Khushbu, Zhao, Shilin, Coullomb, Alexis, Rowe, Dianna J., Lehman, Jonathan M., Irish, Jonathan M., Maldonado, Fabien, Kammer, Michael N., Pancaldi, Vera, Lopez, Carlos F.
Publicado 2023

Correction: Hypoxia Drives Dihydropyrimidine Dehydrogenase Expression in Macrophages and Confers Chemoresistance in Colorectal Cancer

por Malier, Marie, Gharzeddine, Khaldoun, Laverriere, Marie-Hélène, Marsili, Sabrina, Thomas, Fabienne, Court, Magali, Decaens, Thomas, Roth, Gael, Millet, Arnaud
Publicado 2022

Identification of an Imidazopyridine-based Compound as an Oral Selective Estrogen Receptor Degrader for Breast Cancer Therapy

por Pan, Mengwu, Solozobova, Valeria, Kuznik, Nane C., Jung, Nicole, Gräßle, Simone, Gourain, Victor, Heneka, Yvonne M., Cramer von Clausbruch, Christina A., Fuhr, Olaf, Munuganti, Ravi S. N., Maddalo, Danilo, Blattner, Christine, Neeb, Antje, Sharp, Adam, Cato, Laura, Weiss, Carsten, Jeselsohn, Rinath M., Orian-Rousseau, Veronique, Bräse, Stefan, Cato, Andrew C. B.
Publicado 2023

Inhibition of Microsomal Prostaglandin E2 Synthase Reduces Collagen Deposition in Melanoma Tumors and May Improve Immunotherapy Efficacy by Reducing T-cell Exhaustion

por Fukuda, Yasunari, Kim, Sun-Hee, Bustos, Matias A., Cho, Sung-Nam, Roszik, Jason, Burks, Jared K., Kim, Hong, Hoon, Dave S.B., Grimm, Elizabeth A., Ekmekcioglu, Suhendan
Publicado 2023