Characterizing the Immune Microenvironment and Neoantigen Landscape of Hürthle Cell Carcinoma to Identify Potential Immunologic Vulnerabilities

por Ganly, Ian, Kuo, Fengshen, Makarov, Vladimir, Dong, Yiyu, Ghossein, Ronald, Xu, Bin, Morris, Luc G.T., Chan, Timothy A.
Publicado 2023

Dying To Find Out: The Cost of Time at the Dawn of the Multicancer Early Detection Era

por Klein, Eric A., Madhavan, Sarina, Beer, Tomasz M., Bettegowda, Chetan, Liu, Minetta C., Hartman, Anne-Renee, Hackshaw, Allan
Publicado 2023

ZEB1 Is Regulated by K811 Acetylation to Promote Stability, NuRD Complex Interactions, EMT, and NSCLC Metastasis

por Perez-Oquendo, Mabel, Manshouri, Roxsan, Tian, Yanhua, Fradette, Jared J., Rodriguez, B. Leticia, Kundu, Samrat T., Gibbons, Don L.
Publicado 2023

Area Deprivation Index in Patients with Invasive Lobular Carcinoma of the Breast: Associations with Tumor Characteristics and Outcomes

por Kaur, Mandeep, Patterson, Anne, Molina-Vega, Julissa, Rothschild, Harriet, Clelland, Elle, Ewing, Cheryl A., Mujir, Firdows, Esserman, Laura J., Olopade, Olufunmilayo I., Mukhtar, Rita A.
Publicado 2023

Tumor-Agnostic Precision Medicine from the AACR GENIE Database: Clinical Implications

por Gouda, Mohamed A., Nelson, Blessie E., Buschhorn, Lars, Wahida, Adam, Subbiah, Vivek
Publicado 2023

Genomic Profiling of Radiation-Induced Sarcomas Reveals the Immunologic Characteristics and Its Response to Immune Checkpoint Blockade

por Hong, Dong-Chun, Yang, Jing, Sun, Cong, Liu, Yuan-Tao, Shen, Lu-Jun, Xu, Bu-Shu, Que, Yi, Xia, Xiaojun, Zhang, Xing
Publicado 2023

Profiling the Somatic Mutational Landscape of Breast Tumors from Hispanic/Latina Women Reveals Conserved and Unique Characteristics

por Ding, Yuan Chun, Song, Hanbing, Adamson, Aaron W., Schmolze, Daniel, Hu, Donglei, Huntsman, Scott, Steele, Linda, Patrick, Carmina S., Tao, Shu, Hernandez, Natalie, Adams, Charleen D., Fejerman, Laura, Gardner, Kevin, Nápoles, Anna María, Pérez-Stable, Eliseo J., Weitzel, Jeffrey N., Bengtsson, Henrik, Huang, Franklin W., Neuhausen, Susan L., Ziv, Elad
Publicado 2023

Functional and Clinical Characterization of Variants of Uncertain Significance Identifies a Hotspot for Inactivating Missense Variants in RAD51C

por Hu, Chunling, Nagaraj, Anil Belur, Shimelis, Hermela, Montalban, Gemma, Lee, Kun Y., Huang, Huaizhi, Lumby, Carolyn A., Na, Jie, Susswein, Lisa R., Roberts, Maegan E., Marshall, Megan L., Hiraki, Susan, LaDuca, Holly, Chao, Elizabeth, Yussuf, Amal, Pesaran, Tina, Neuhausen, Susan L., Haiman, Christopher A., Kraft, Peter, Lindstrom, Sara, Palmer, Julie R., Teras, Lauren R., Vachon, Celine M., Yao, Song, Ong, Irene, Nathanson, Katherine L., Weitzel, Jeffrey N., Boddicker, Nicholas, Gnanaolivu, Rohan, Polley, Eric C., Mer, Georges, Cui, Gaofeng, Karam, Rachid, Richardson, Marcy E., Domchek, Susan M., Yadav, Siddhartha, Hruska, Kathleen S., Dolinsky, Jill, Weroha, S. John, Hart, Steven N., Simard, Jacques, Masson, Jean Yves, Pang, Yuan-Ping, Couch, Fergus J.
Publicado 2023

Preclinical Evaluation of 9MW2821, a Site-Specific Monomethyl Auristatin E–based Antibody–Drug Conjugate for Treatment of Nectin-4–expressing Cancers

por Zhou, Wei, Fang, Peng, Yu, Dongan, Ren, Hongyuan, You, Meng, Yin, Long, Mei, Fei, Zhu, Huikai, Wang, Zhenzhen, Xu, Hui, Cao, Yuxia, Sun, Xiaowei, Xu, Xiaohong, Bi, Jianjun, Wang, Jin, Ma, Lanping, Wang, Xin, Chen, Lin, Zhang, Yongliang, Cen, Xiaowei, Zhu, Xi, Lou, Liguang, Liu, Datao, Tan, Xiaoding, Yang, Jinliang, Meng, Tao, Shen, Jingkang
Publicado 2023

Maveropepimut-S, a DPX-Based Immune-Educating Therapy, Shows Promising and Durable Clinical Benefit in Patients with Recurrent Ovarian Cancer, a Phase II Trial

por Dorigo, Oliver, Oza, Amit M., Pejovic, Tanja, Ghatage, Prafull, Ghamande, Sharad, Provencher, Diane, MacDonald, Lisa D., Torrey, Heather, Kaliaperumal, Valarmathy, Ebrahimizadeh, Walead, Hirsch, Heather A., Bramhecha, Yogesh, Villella, Jeannine, Fiset, Stephan
Publicado 2023

An Open-label Phase I Study of GDC-0927 in Postmenopausal Women with Locally Advanced or Metastatic Estrogen Receptor–Positive Breast Cancer

por Chandarlapaty, Sarat, Dickler, Maura N., Perez Fidalgo, Jose Alejandro, Villanueva-Vázquez, Rafael, Giltnane, Jennifer, Gates, Mary, Chang, Ching-Wei, Cheeti, Sravanthi, Fredrickson, Jill, Wang, Xiaojing, Collier, Ann, Moore, Heather M., Metcalfe, Ciara, Lauchle, Jennifer, Humke, Eric W., Bardia, Aditya
Publicado 2023

Folate Intake and Ovarian Cancer Risk among Women with Endometriosis: A Case–Control Study from the Ovarian Cancer Association Consortium

por Gersekowski, Kate, Ibiebele, Torukiri I, Doherty, Jennifer A., Harris, Holly R., Goodman, Marc T., Terry, Kathryn L., Wu, Anna H., Bandera, Elisa V., Qin, Bo, Ong, Jue-Sheng, Tyrer, Jonathan P., Dixon-Suen, Suzanne C., Modugno, Francesmary, Risch, Harvey A, Webb, Penelope M.
Publicado 2023

Associations of Race and Ethnicity with Hepatocellular Carcinoma, Decompensation, and Mortality in US Veterans with Cirrhosis

por VoPham, Trang, Cravero, Anne, Feld, Lauren D., Green, Pamela, Feng, Ziding, Berry, Kristin, Kim, Nicole J., Vutien, Philip, Mendoza, Jason A., Ioannou, George N.
Publicado 2023

A Comparative Study of Neuroendocrine Heterogeneity in Small Cell Lung Cancer and Neuroblastoma

por Cai, Ling, DeBerardinis, Ralph J., Xie, Yang, Minna, John D., Xiao, Guanghua
Publicado 2023

APR-246 Enhances Colorectal Cancer Sensitivity to Radiotherapy

por Xie, Xuqin, Fan, Chuanwen, Luo, Bin, Zhang, Jing, Jensen, Lasse D., Burman, Jonas, Jönsson, Carolin, Ljusberg, Anna, Larsson, Peter, Zhao, Zengren, Sun, Xiao-Feng
Publicado 2023

Dynamic Intestinal Stem Cell Plasticity and Lineage Remodeling by a Nutritional Environment Relevant to Human Risk for Tumorigenesis

por Choi, Jiahn, Zhang, Xusheng, Li, Wenge, Houston, Michele, Peregrina, Karina, Dubin, Robert, Ye, Kenny, Augenlicht, Leonard
Publicado 2023

Dissecting Intra-tumor Heterogeneity in the Glioblastoma Microenvironment Using Fluorescence-Guided Multiple Sampling

por García-Montaño, Leopoldo A., Licón-Muñoz, Yamhilette, Martinez, Frank J., Keddari, Yasine R., Ziemke, Michael K., Chohan, Muhammad O., Piccirillo, Sara G.M.
Publicado 2023

Oxidative Phosphorylation Fueled by Fatty Acid Oxidation Sensitizes Leukemic Stem Cells to Cold

por Griessinger, Emmanuel, Pereira-Martins, Diego, Nebout, Marielle, Bosc, Claudie, Saland, Estelle, Boet, Emiline, Sahal, Ambrine, Chiche, Johanna, Debayle, Delphine, Fleuriot, Lucile, Pruis, Maurien, De Mas, Véronique, Vergez, François, Récher, Christian, Huls, Gerwin, Sarry, Jean-Emmanuel, Schuringa, Jan Jacob, Peyron, Jean-François
Publicado 2023

Proteasome Inhibition Sensitizes Liposarcoma to MDM2 Inhibition with Nutlin-3 by Activating the ATF4/CHOP Stress Response Pathway

por Ludwig, Michael P., Galbraith, Matthew D., Eduthan, Neetha Paul, Hill, Amanda A., Clay, Michael R., Tellez, Cristiam Moreno, Wilky, Breelyn A., Elias, Anthony, Espinosa, Joaquin M., Sullivan, Kelly D.
Publicado 2023

Deficiency of the Polycomb Protein RYBP and TET Methylcytosine Oxidases Promotes Extensive CpG Island Hypermethylation and Malignant Transformation

por Cui, Wei, Huang, Zhijun, Jin, Seung-Gi, Johnson, Jennifer, Lau, Kin H., Hostetter, Galen, Pfeifer, Gerd P.
Publicado 2023