Syk Inhibition Reprograms Tumor-Associated Macrophages and Overcomes Gemcitabine-Induced Immunosuppression in Pancreatic Ductal Adenocarcinoma

por Rohila, Deepak, Park, In Hwan, Pham, Timothy V., Weitz, Jonathan, Hurtado de Mendoza, Tatiana, Madheswaran, Suresh, Ishfaq, Mehreen, Beaman, Cooper, Tapia, Elisabette, Sun, Siming, Patel, Jay, Tamayo, Pablo, Lowy, Andrew M., Joshi, Shweta
Publicado 2023

Targeted Single-cell Isolation of Spontaneously Escaping Live Melanoma Cells for Comparative Transcriptomics

por Tearle, Jacqueline L.E., Arjunan, Satya N.V., Tay, Szun S., Colakoglu, Feyza, Cremasco, James, Golo, Matteo, Biro, Maté
Publicado 2023

Cancer Epidemiology in the Northeastern United States (2013–2017)

por Rees, Judy R., Weiss, Julie E., Gunn, Christine M., Carlos, Heather A., Dragnev, Nathalie C., Supattapone, Emma Y., Tosteson, Anna N.A., Kraft, Sally A., Vahdat, Linda T., Peacock, Janet L.
Publicado 2023

Association of Antifolate Response Signature Status and Clinical Activity of Pemetrexed-Platinum Chemotherapy in Non–Small Cell Lung Cancer: The Piedmont Study

por Eisner, Joel R., Mayhew, Gregory M., Davison, James M., Beebe, Kirk D., Shibata, Yoichiro, Guo, Yuelong, Farhangfar, Carol, Farhangfar, Farhang, Uronis, Joshua M., Conroy, Jeffrey M., Milburn, Michael V., Hayes, David Neil, Mileham, Kathryn F.
Publicado 2023

Clinical Activity of Combined Telomerase Vaccination and Pembrolizumab in Advanced Melanoma: Results from a Phase I Trial

por Ellingsen, Espen B., O'Day, Steven, Mezheyeuski, Artur, Gromadka, Agnieszka, Clancy, Trevor, Kristedja, Timothy S., Milhem, Mohammed, Zakharia, Yousef
Publicado 2023

BBT-176, a Novel Fourth-Generation Tyrosine Kinase Inhibitor for Osimertinib-Resistant EGFR Mutations in Non–Small Cell Lung Cancer

por Lim, Sun Min, Fujino, Toshio, Kim, Chulwon, Lee, Gwanghee, Lee, Yong-Hee, Kim, Dong-Wan, Ahn, Jin Seok, Mitsudomi, Tetsuya, Jin, Taiguang, Lee, Sang-Yoon
Publicado 2023

The Genomic and Epigenomic Landscape of Double-Negative Metastatic Prostate Cancer

por Lundberg, Arian, Zhang, Meng, Aggarwal, Rahul, Li, Haolong, Zhang, Li, Foye, Adam, Sjöström, Martin, Chou, Jonathan, Chang, Kevin, Moreno-Rodriguez, Thaidy, Shrestha, Raunak, Baskin, Avi, Zhu, Xiaolin, Weinstein, Alana S., Younger, Noah, Alumkal, Joshi J., Beer, Tomasz M., Chi, Kim N., Evans, Christopher P., Gleave, Martin, Lara, Primo N., Reiter, Rob E., Rettig, Matthew B., Witte, Owen N., Wyatt, Alexander W., Feng, Felix Y., Small, Eric J., Quigley, David A.
Publicado 2023

Functional Homologous Recombination Assay on FFPE Specimens of Advanced High-Grade Serous Ovarian Cancer Predicts Clinical Outcomes

por Pikkusaari, Sanna, Tumiati, Manuela, Virtanen, Anni, Oikkonen, Jaana, Li, Yilin, Perez-Villatoro, Fernando, Muranen, Taru, Salko, Matilda, Huhtinen, Kaisa, Kanerva, Anna, Koskela, Heidi, Tapper, Johanna, Koivisto-Korander, Riitta, Joutsiniemi, Titta, Haltia, Ulla-Maija, Lassus, Heini, Hautaniemi, Sampsa, Färkkilä, Anniina, Hynninen, Johanna, Hietanen, Sakari, Carpén, Olli, Kauppi, Liisa
Publicado 2023

ENIGMA CHEK2gether Project: A Comprehensive Study Identifies Functionally Impaired CHEK2 Germline Missense Variants Associated with Increased Breast Cancer Risk

por Stolarova, Lenka, Kleiblova, Petra, Zemankova, Petra, Stastna, Barbora, Janatova, Marketa, Soukupova, Jana, Achatz, Maria Isabel, Ambrosone, Christine, Apostolou, Paraskevi, Arun, Banu K., Auer, Paul, Barnard, Mollie, Bertelsen, Birgitte, Blok, Marinus J., Boddicker, Nicholas, Brunet, Joan, Burnside, Elizabeth S., Calvello, Mariarosaria, Campbell, Ian, Chan, Sock Hoai, Chen, Fei, Chiang, Jian Bang, Coppa, Anna, Cortesi, Laura, Crujeiras-González, Ana, De Leeneer, Kim, De Putter, Robin, DePersia, Allison, Devereux, Lisa, Domchek, Susan, Efremidis, Anna, Engel, Christoph, Ernst, Corinna, Evans, D. Gareth R., Feliubadaló, Lidia, Fostira, Florentia, Fuentes-Ríos, Olivia, Gómez-García, Encarna B., González, Sara, Haiman, Christopher, Hansen, Thomas van Overeem, Hauke, Jan, Hodge, James, Hu, Chunling, Huang, Hongyan, Ishak, Nur Diana Binte, Iwasaki, Yusuke, Konstantopoulou, Irene, Kraft, Peter, Lacey, James, Lázaro, Conxi, Li, Na, Lim, Weng Khong, Lindstrom, Sara, Lori, Adriana, Martinez, Elana, Martins, Alexandra, Matsuda, Koichi, Matullo, Giuseppe, McInerny, Simone, Michailidou, Kyriaki, Montagna, Marco, Monteiro, Alvaro N.A., Mori, Luigi, Nathanson, Katherine, Neuhausen, Susan L., Nevanlinna, Heli, Olson, Janet E., Palmer, Julie, Pasini, Barbara, Patel, Alpa, Piane, Maria, Poppe, Bruce, Radice, Paolo, Renieri, Alessandra, Resta, Nicoletta, Richardson, Marcy E., Rosseel, Toon, Ruddy, Kathryn J., Santamariña, Marta, Dos Santos, Elizabeth Santana, Teras, Lauren, Toland, Amanda E., Trentham-Dietz, Amy, Vachon, Celine M., Volk, Alexander E., Weber-Lassalle, Nana, Weitzel, Jeffrey N., Wiesmuller, Lisa, Winham, Stacey, Yadav, Siddhartha, Yannoukakos, Drakoulis, Yao, Song, Zampiga, Valentina, Zethoven, Magnus, Zhang, Ze Wen, Zima, Tomas, Spurdle, Amanda B., Vega, Ana, Rossing, Maria, Del Valle, Jesús, De Nicolo, Arcangela, Hahnen, Eric, Claes, Kathleen B.M., Ngeow, Joanne, Momozawa, Yukihide, James, Paul A., Couch, Fergus J., Macurek, Libor, Kleibl, Zdenek
Publicado 2023

B-cell Receptor Pathway Mutations Are Infrequent in Patients with Chronic Lymphocytic Leukemia on Continuous Ibrutinib Therapy

por Woyach, Jennifer A., Ghia, Paolo, Byrd, John C., Ahn, Inhye E., Moreno, Carol, O'Brien, Susan M., Jones, Daniel, Cheung, Leo W.K., Chong, Elizabeth, Kwei, Kevin, Dean, James P., James, Danelle F., Wiestner, Adrian
Publicado 2023

Patient-Reported Outcomes as Interradiographic Predictors of Response in Non–Small Cell Lung Cancer

por Bhatt, Ambika S., Schabath, Matthew B., Hoogland, Aasha I., Jim, Heather S.L., Brady-Nicholls, Renee
Publicado 2023

Dual Targeting of Apoptotic and Signaling Pathways in T-Lineage Acute Lymphoblastic Leukemia

por Saygin, Caner, Giordano, Giorgia, Shimamoto, Kathryn, Eisfelder, Bart, Thomas-Toth, Anika, Venkataraman, Girish, Ananthanarayanan, Vijayalakshmi, Vincent, Tiffaney L., DuVall, Adam, Patel, Anand A., Chen, Yi, Tan, Fenlai, Anthony, Stephen P., Chen, Yu, Shen, Yue, Odenike, Olatoyosi, Teachey, David T., Kee, Barbara L., LaBelle, James, Stock, Wendy
Publicado 2023

Gold Nanostars Obviate Limitations to Laser Interstitial Thermal Therapy (LITT) for the Treatment of Intracranial Tumors

por Srinivasan, Ethan S., Liu, Yang, Odion, Ren A., Chongsathidkiet, Pakawat, Wachsmuth, Lucas P., Haskell-Mendoza, Aden P., Edwards, Ryan M., Canning, Aidan J., Willoughby, Gavin, Hinton, Joseph, Norton, Stephen J., Lascola, Christopher D., Maccarini, Paolo F., Mariani, Christopher L., Vo-Dinh, Tuan, Fecci, Peter E.
Publicado 2023

Preclinical Characterization and Phase I Trial Results of INBRX-109, A Third-Generation, Recombinant, Humanized, Death Receptor 5 Agonist Antibody, in Chondrosarcoma

por Subbiah, Vivek, Chawla, Sant P., Conley, Anthony P., Wilky, Breelyn A., Tolcher, Anthony, Lakhani, Nehal J., Berz, David, Andrianov, Vasily, Crago, William, Holcomb, Monica, Hussain, Abrahim, Veldstra, Carson, Kalabus, James, O’Neill, Brianne, Senne, Lane, Rowell, Emily, Heidt, Analeah B., Willis, Katelyn M., Eckelman, Brendan P.
Publicado 2023

DNA-Methylome–Based Tumor Hypoxia Classifier Identifies HPV-Negative Head and Neck Cancer Patients at Risk for Locoregional Recurrence after Primary Radiochemotherapy

por Tawk, Bouchra, Rein, Katrin, Schwager, Christian, Knoll, Maximilian, Wirkner, Ute, Hörner-Rieber, Juliane, Liermann, Jakob, Kurth, Ina, Balermpas, Panagiotis, Rödel, Claus, Linge, Annett, Löck, Steffen, Lohaus, Fabian, Tinhofer, Ingeborg, Krause, Mechtild, Stuschke, Martin, Grosu, Anca Ligia, Zips, Daniel, Combs, Stephanie E., Belka, Claus, Stenzinger, Albrecht, Herold-Mende, Christel, Baumann, Michael, Schirmacher, Peter, Debus, Jürgen, Abdollahi, Amir
Publicado 2023

Discovery and Targeting of a Noncanonical Mechanism of Sarcoma Resistance to ADI-PEG20 Mediated by the Microenvironment

por Rogers, Leonard C., Kremer, Jeff C., Brashears, Caitlyn B., Lin, Zongtao, Hu, Zhixian, Bastos, Alliny C.S., Baker, Adriana, Fettig, Nicole, Zhou, Dong, Shoghi, Kooresh I., Dehner, Carina A., Chrisinger, John S.A., Bomalaski, John S., Garcia, Benjamin A., Oyama, Toshinao, White, Eileen P., Van Tine, Brian A.
Publicado 2023

Elevated Mast Cell Abundance Is Associated with Enrichment of CCR2(+) Cytotoxic T Cells and Favorable Prognosis in Lung Adenocarcinoma

por Fan, Fanfan, Gao, Jian, Zhao, Yue, Wang, Jun, Meng, Lu, Ma, Jiaqiang, Li, Teng, Han, Han, Lai, Jinglei, Gao, Zhendong, Li, Xiongfei, Guo, Ran, Cao, Zhiwei, Zhang, Yang, Zhang, Xiaoming, Chen, Haiquan
Publicado 2023

Intermetastatic and Intrametastatic Heterogeneity Shapes Adaptive Therapy Cycling Dynamics

por Gallaher, Jill, Strobl, Maximilian, West, Jeffrey, Gatenby, Robert, Zhang, Jingsong, Robertson-Tessi, Mark, Anderson, Alexander R.A.
Publicado 2023

High-Throughput Drug Screening of Primary Tumor Cells Identifies Therapeutic Strategies for Treating Children with High-Risk Cancer

por Mayoh, Chelsea, Mao, Jie, Xie, Jinhan, Tax, Gabor, Chow, Shu-Oi, Cadiz, Roxanne, Pazaky, Karina, Barahona, Paulette, Ajuyah, Pamela, Trebilcock, Peter, Malquori, Angela, Gunther, Kate, Avila, Anica, Yun, Doo Young, Alfred, Stephanie, Gopalakrishnan, Anjana, Kamili, Alvin, Wong, Marie, Cowley, Mark J., Jessop, Sophie, Lau, Loretta M.S., Trahair, Toby N., Ziegler, David S., Fletcher, Jamie I., Gifford, Andrew J., Tsoli, Maria, Marshall, Glenn M., Haber, Michelle, Tyrrell, Vanessa, Failes, Timothy W., Arndt, Greg M., Lock, Richard B., Ekert, Paul G., Dolman, M. Emmy M.
Publicado 2023

Kinase Inhibitor Pulldown Assay Identifies a Chemotherapy Response Signature in Triple-negative Breast Cancer Based on Purine-binding Proteins

por Wang, Junkai, Saltzman, Alexander B., Jaehnig, Eric J., Lei, Jonathan T., Malovannaya, Anna, Holt, Matthew V., Young, Meggie N., Rimawi, Mothaffar F., Ademuyiwa, Foluso O., Anurag, Meenakshi, Kim, Beom-Jun, Ellis, Matthew J.
Publicado 2023