Activating Inducible T-cell Costimulator Yields Antitumor Activity Alone and in Combination with Anti-PD-1 Checkpoint Blockade

por Yadavilli, Sapna, Waight, Jeremy D., Brett, Sara, Bi, Meixia, Zhang, Tianqian, Liu, Yao-Bin, Ellis, Catherine, Turner, David C., Hahn, Ashleigh, Shi, Hong, Seestaller-Wehr, Laura, Jing, Junping, Xie, Qing, Shaik, Jafar Sadik, Ji, Xiao, Gagnon, Robert, Fieles, William, Hook, Laura, Grant, Steven, Hopley, Stephanie, DeYoung, M. Phillip, Blackwell, Christina, Chisamore, Michael, Biddlecombe, Robert, Figueroa, David J., Hopson, Christopher B., Srinivasan, Roopa, Smothers, James, Maio, Michele, Rischin, Danny, Olive, Daniel, Paul, Elaine, Mayes, Patrick A., Hoos, Axel, Ballas, Marc
Publicado 2023

Activator Protein-1 (AP-1) Signaling Inhibits the Growth of Ewing Sarcoma Cells in Response to DNA Replication Stress

por Croushore, Emma E., Koppenhafer, Stacia L., Goss, Kelli L., Geary, Elizabeth L., Gordon, David J.
Publicado 2023

LNS8801 inhibits Acute Myeloid Leukemia by Inducing the Production of Reactive Oxygen Species and Activating the Endoplasmic Reticulum Stress Pathway

por Lee, Inyoung, Doepner, Miriam, Weissenrieder, Jillian, Majer, Ariana D., Mercado, Sophia, Estell, Angela, Natale, Christopher A., Sung, Pamela J., Foskett, J. Kevin, Carroll, Martin P., Ridky, Todd W.
Publicado 2023

Dodecafluoropentane Emulsion as a Radiosensitizer in Glioblastoma Multiforme

por Lickliter, Jason D., Ruben, Jeremy, Kichenadasse, Ganessan, Jennens, Ross, Gzell, Cecelia, Mason, Ralph P., Zhou, Heling, Becker, Jennifer, Unger, Evan, Stea, Baldassarre
Publicado 2023

Natural Killer Cell Activation by Ubiquitin-specific Protease 6 Mediates Tumor Suppression in Ewing Sarcoma

por Jain, Kanika, Henrich, Ian C., Quick, Laura, Young, Robert, Mondal, Shreya, Oliveira, Andre M., Blobel, Gerd A., Chou, Margaret M.
Publicado 2023

A Pilot Study of Neoadjuvant Nivolumab, Ipilimumab, and Intralesional Oncolytic Virotherapy for HER2-negative Breast Cancer

por Nguyen, Vina P., Campbell, Katie M., Nowicki, Theodore S., Elumalai, Nila, Medina, Egmidio, Baselga-Carretero, Ignacio, DiNome, Maggie L., Chang, Helena R., Oseguera, Denise K., Ribas, Antoni, Glaspy, John A.
Publicado 2023

A First-in-human, Dose-escalation Study of the Methionine Aminopeptidase 2 Inhibitor M8891 in Patients with Advanced Solid Tumors

por Carducci, Michael A., Wang, Ding, Habermehl, Christina, Bödding, Matthias, Rohdich, Felix, Lignet, Floriane, Duecker, Klaus, Karpenko, Oleksandr, Pudelko, Linda, Gimmi, Claude, LoRusso, Patricia
Publicado 2023

Multicellular Complex Tumor Spheroid Response to DNA Repair Inhibitors in Combination with DNA-damaging Drugs

por Dexheimer, Thomas S., Coussens, Nathan P., Silvers, Thomas, Wright, John, Morris, Joel, Doroshow, James H., Teicher, Beverly A.
Publicado 2023

Tusamitamab Ravtansine in Patients with Advanced Solid Tumors: Phase I Study of Safety, Pharmacokinetics, and Antitumor Activity Using Alternative Dosing Regimens

por Tabernero, Josep, Bedard, Philippe L., Bang, Yung-Jue, Vieito, Maria, Ryu, Min-Hee, Fagniez, Nathalie, Chadjaa, Mustapha, Soufflet, Christine, Masson, Nina, Gazzah, Anas
Publicado 2023

Gemcitabine, Docetaxel, Capecitabine, Cisplatin, Irinotecan as First-line Treatment for Metastatic Pancreatic Cancer

por Wilbur, H. Catherine, Durham, Jennifer N., Lim, Su Jin, Purtell, Katrina, Bever, Katherine M., Laheru, Daniel A., De Jesus-Acosta, Ana, Azad, Nilofer S., Wilt, Bradley, Diaz, Luis A., Le, Dung T., Wang, Hao
Publicado 2023

A Survey of Cancer Risk Behaviors, Beliefs, and Social Drivers of Health in New Hampshire and Vermont

por Skipper, Thomas A., Weiss, Julie E., Carlos, Heather A., Gunn, Christine M., Hasson, Rian M., Peacock, Janet L., Schiffelbein, Jenna E., Tosteson, Anna N.A., Lansigan, Frederick, Rees, Judy R.
Publicado 2023

Correction: The Genetic Landscape of Ocular Adnexa MALT Lymphoma Reveals Frequent Aberrations in NFAT and MEF2B Signaling Pathways

por Magistri, Marco, Happ, Lanie E., Ramdial, Jeremy, Lu, XiaoQing, Stathias, Vasileios, Kunkalla, Kranthi, Agarwal, Nitin, Jiang, Xiaoyu, Schürer, Stephan C., Dubovy, Sander R., Chapman, Jennifer R., Vega, Francisco, Dave, Sandeep, Lossos, Izidore S.
Publicado 2023

Development and Validation of a 15-gene Expression Signature with Superior Prognostic Ability in Stage II Colorectal Cancer

por Rokavec, Matjaz, Özcan, Elif, Neumann, Jens, Hermeking, Heiko
Publicado 2023

Whole-genome CpG-resolution DNA Methylation Profiling of HNSCC Reveals Distinct Mechanisms of Carcinogenesis for Fine-scale HPV+ Cancer Subtypes

por Qin, Tingting, Li, Shiting, Henry, Leanne E., Chou, Elysia, Cavalcante, Raymond G., Garb, Bailey F., D'Silva, Nisha J., Rozek, Laura S., Sartor, Maureen A.
Publicado 2023

Demethylation of EHMT1/GLP Protein Reprograms Its Transcriptional Activity and Promotes Prostate Cancer Progression

por Besschetnova, Anna, Han, Wanting, Liu, Mingyu, Gao, Yanfei, Li, Muqing, Wang, Zifeng, Labaf, Maryam, Patalano, Susan, Venkataramani, Kavita, Muriph, Rachel E., Macoska, Jill A., Siegfried, Kellee R., Evans, Jason, Balk, Steven P., Gao, Shuai, Han, Dong, Cai, Changmeng
Publicado 2023

Beyond Neoantigens: Antigens Derived from Tumor Drivers as Cancer Vaccine Targets

por Crosby, Erika J., Hartman, Zachary C., Lyerly, H. Kim
Publicado 2023

Host Interactions with Engineered T-cell Micropharmacies

por Bourne, Christopher M., Wallisch, Patrick, Dacek, Megan M., Gardner, Thomas J., Pierre, Stephanie, Vogt, Kristen, Corless, Broderick C., Bah, Mamadou A., Romero-Pichardo, Jesus E., Charles, Angel, Kurtz, Keifer G., Tan, Derek S., Scheinberg, David A.
Publicado 2023

KIT and PDGFRA Mutations and Survival of Gastrointestinal Stromal Tumor Patients Treated with Adjuvant Imatinib in a Randomized Trial

por Joensuu, Heikki, Wardelmann, Eva, Eriksson, Mikael, Reichardt, Annette, Hall, Kirsten Sundby, Schütte, Jochen, Cameron, Silke, Hohenberger, Peter, Sihto, Harri, Jost, Philipp J., Lindner, Lars H., Bauer, Sebastian, Nilsson, Bengt, Kallio, Raija, Pesonen, Tommi, Reichardt, Peter
Publicado 2023

Adjuvant Nivolumab versus Ipilimumab in Resected Stage III/IV Melanoma: 5-Year Efficacy and Biomarker Results from CheckMate 238

por Larkin, James, Del Vecchio, Michele, Mandalá, Mario, Gogas, Helen, Arance Fernandez, Ana M., Dalle, Stéphane, Cowey, Charles Lance, Schenker, Michael, Grob, Jean-Jacques, Chiarion-Sileni, Vanna, Marquez-Rodas, Ivan, Butler, Marcus O., Di Giacomo, Anna Maria, Middleton, Mark R., Lutzky, Jose, de la Cruz-Merino, Luis, Arenberger, Petr, Atkinson, Victoria, Hill, Andrew G., Fecher, Leslie A., Millward, Michael, Nathan, Paul D., Khushalani, Nikhil I., Queirolo, Paola, Ritchings, Corey, Lobo, Maurice, Askelson, Margarita, Tang, Hao, Dolfi, Sonia, Ascierto, Paolo A., Weber, Jeffrey
Publicado 2023

Results of an Open-label, Phase Ia/b Study of Pembrolizumab plus Olaratumab in Patients with Unresectable, Locally Advanced, or Metastatic Soft-Tissue Sarcoma

por Schöffski, Patrick, Bahleda, Rastislav, Wagner, Andrew J., Burgess, Melissa A., Junker, Niels, Chisamore, Michael, Peterson, Patrick, Szpurka, Anna M., Ceccarelli, Matteo, Tap, William D.
Publicado 2023